Modeling effective connectivity in high-dimensional cortical source signals
To study the effective connectivity among sources in a densely voxelated (high-dimensional) cortical surface, we develop the source-space factor VAR model. The first step in our procedure is to estimate cortical activity from multichannel electroencephalograms (EEG) using anatomically constrained br...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Institute of Electrical and Electronics Engineers Inc.
2016
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/72019/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989252431&doi=10.1109%2fJSTSP.2016.2600023&partnerID=40&md5=a38427785d9d527c9abe570d1510e936 |
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| Summary: | To study the effective connectivity among sources in a densely voxelated (high-dimensional) cortical surface, we develop the source-space factor VAR model. The first step in our procedure is to estimate cortical activity from multichannel electroencephalograms (EEG) using anatomically constrained brain imaging methods. Following parcellation of the cortical surface into disjoint regions of interest (ROIs), latent factors within each ROI are computed using principal component analysis. These factors are ROI-specific low-rank approximations (or representations) which allow for efficient estimation of connectivity in the high-dimensional cortical source space. The second step is to model effective connectivity between ROIs by fitting a VAR model jointly on all the latent processes. Measures of cortical connectivity, in particular partial directed coherence, are formulated using the VAR parameters. We illustrate the proposed model to investigate connectivity and interactions between cortical ROIs during rest. |
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