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Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass

In this study, we have presented the structural and in vitro characterization of electrospun polylactic acid (PLA)/Chitosan nanofibers coated with cerium, copper or silver doped bioactive glasses (CeBG/CuBG/AgBG). Bead-free, smooth surfaced nanofibers were successfully prepared by using electrospinn...

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Main Authors: Goh, Y. F., Akram, M., Alshemary, A., Hussain, R.
Format: Article
Published: Elsevier B.V. 2016
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/71895/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975789656&doi=10.1016%2fj.apsusc.2016.06.054&partnerID=40&md5=cf9ac75d95353c5d26efa745fdfc8267
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spelling my.utm.718952017-11-23T01:37:07Z http://eprints.utm.my/id/eprint/71895/ Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass Goh, Y. F. Akram, M. Alshemary, A. Hussain, R. QD Chemistry In this study, we have presented the structural and in vitro characterization of electrospun polylactic acid (PLA)/Chitosan nanofibers coated with cerium, copper or silver doped bioactive glasses (CeBG/CuBG/AgBG). Bead-free, smooth surfaced nanofibers were successfully prepared by using electrospinning technique. The nanocomposite fibers were obtained using a facile dip-coating method, their antibacterial activities against E. coliE. coli (ATCC 25922 strains) were measured by the disk diffusion method after 24 h of incubation at 37 °C. CeBG and CuBG decorated PLA/Chitosan nanofibers did not develop an inhibition zone against the bacteria. On the other hand, nanofibers coated with AgBG developed an inhibition zone against the bacteria. The as-prepared nanocomposite fibers were immersed in SBF for 1, 3 and 7 days in Simulated Body Fluid (SBF) for evaluation of in vitro bioactivity. All samples induced the formation of crystallites with roughly ruffled morphology and the pores of fibers were covered with the extensive growth of crystallites. Energy Dispersive X-ray (EDX) composition analysis showed that the crystallites possessed Ca/P ratio close to 1.67, confirming the good in-vitro bioactivity of the fibers. Elsevier B.V. 2016 Article PeerReviewed Goh, Y. F. and Akram, M. and Alshemary, A. and Hussain, R. (2016) Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass. Applied Surface Science, 387 . pp. 1-7. ISSN 0169-4332 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975789656&doi=10.1016%2fj.apsusc.2016.06.054&partnerID=40&md5=cf9ac75d95353c5d26efa745fdfc8267
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Goh, Y. F.
Akram, M.
Alshemary, A.
Hussain, R.
Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
description In this study, we have presented the structural and in vitro characterization of electrospun polylactic acid (PLA)/Chitosan nanofibers coated with cerium, copper or silver doped bioactive glasses (CeBG/CuBG/AgBG). Bead-free, smooth surfaced nanofibers were successfully prepared by using electrospinning technique. The nanocomposite fibers were obtained using a facile dip-coating method, their antibacterial activities against E. coliE. coli (ATCC 25922 strains) were measured by the disk diffusion method after 24 h of incubation at 37 °C. CeBG and CuBG decorated PLA/Chitosan nanofibers did not develop an inhibition zone against the bacteria. On the other hand, nanofibers coated with AgBG developed an inhibition zone against the bacteria. The as-prepared nanocomposite fibers were immersed in SBF for 1, 3 and 7 days in Simulated Body Fluid (SBF) for evaluation of in vitro bioactivity. All samples induced the formation of crystallites with roughly ruffled morphology and the pores of fibers were covered with the extensive growth of crystallites. Energy Dispersive X-ray (EDX) composition analysis showed that the crystallites possessed Ca/P ratio close to 1.67, confirming the good in-vitro bioactivity of the fibers.
format Article
author Goh, Y. F.
Akram, M.
Alshemary, A.
Hussain, R.
author_facet Goh, Y. F.
Akram, M.
Alshemary, A.
Hussain, R.
author_sort Goh, Y. F.
title Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
title_short Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
title_full Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
title_fullStr Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
title_full_unstemmed Antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
title_sort antibacterial polylactic acid/chitosan nanofibers decorated with bioactive glass
publisher Elsevier B.V.
publishDate 2016
url http://eprints.utm.my/id/eprint/71895/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975789656&doi=10.1016%2fj.apsusc.2016.06.054&partnerID=40&md5=cf9ac75d95353c5d26efa745fdfc8267
_version_ 1643656307319767040
score 13.211869

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