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Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection

Till to date, the advancement ofmedical science and technology is still unable to provide inclusive treatment to liver inflammation caused by neither microbial invasion nor antibiotics nor environmental toxins. Therefore, this article provides the basic knowledge of liver inflammation up to the cell...

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Main Author: Chua, Lee Suan
Format: Article
Published: John Wiley and Sons Ltd 2014
Subjects:
TX Home economics
Online Access:http://eprints.utm.my/id/eprint/62477/
http://dx.doi.org/10.1002/ptr.5193
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spelling my.utm.624772017-06-15T01:05:45Z http://eprints.utm.my/id/eprint/62477/ Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection Chua, Lee Suan TX Home economics Till to date, the advancement ofmedical science and technology is still unable to provide inclusive treatment to liver inflammation caused by neither microbial invasion nor antibiotics nor environmental toxins. Therefore, this article provides the basic knowledge of liver inflammation up to the cellular level and its current medical treatment for inflammatory symptom suppression. Because of the adverse effects of drug treatment, people start looking for comprehensive alternative nowadays. Herbal medicine is believed to be the best of choice because it is being practiced until now for centuries. Although numerous herbal plants have been reported for their efficacies in liver protection, Andrographis paniculata is the most widely used herb for hepatoprotection, particularly in Ayurveda and traditional Chinese medicine. This review covers the significant observation on the biochemical responses due to the experimental induction of liver damage in vitro and in vivo using the marker compound of the herb, namely andrographolide and its derivatives. The standardized extract of A. paniculata with the right phytochemical composition of diterpenic labdanes is likely to have tremendous potential for the development of hepatoprotective medicine. This standardized herbal medicine may not provide immediate remedy, but it can be considered as a comprehensive therapy for liver inflammation. John Wiley and Sons Ltd 2014 Article PeerReviewed Chua, Lee Suan (2014) Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection. Phytotherapy Research, 28 (11). p. 1598. ISSN 0951-418X http://dx.doi.org/10.1002/ptr.5193
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TX Home economics
spellingShingle TX Home economics
Chua, Lee Suan
Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
description Till to date, the advancement ofmedical science and technology is still unable to provide inclusive treatment to liver inflammation caused by neither microbial invasion nor antibiotics nor environmental toxins. Therefore, this article provides the basic knowledge of liver inflammation up to the cellular level and its current medical treatment for inflammatory symptom suppression. Because of the adverse effects of drug treatment, people start looking for comprehensive alternative nowadays. Herbal medicine is believed to be the best of choice because it is being practiced until now for centuries. Although numerous herbal plants have been reported for their efficacies in liver protection, Andrographis paniculata is the most widely used herb for hepatoprotection, particularly in Ayurveda and traditional Chinese medicine. This review covers the significant observation on the biochemical responses due to the experimental induction of liver damage in vitro and in vivo using the marker compound of the herb, namely andrographolide and its derivatives. The standardized extract of A. paniculata with the right phytochemical composition of diterpenic labdanes is likely to have tremendous potential for the development of hepatoprotective medicine. This standardized herbal medicine may not provide immediate remedy, but it can be considered as a comprehensive therapy for liver inflammation.
format Article
author Chua, Lee Suan
author_facet Chua, Lee Suan
author_sort Chua, Lee Suan
title Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
title_short Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
title_full Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
title_fullStr Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
title_full_unstemmed Review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
title_sort review on liver inflammation and antiinflammatory activity of andrographis paniculata for hepatoprotection
publisher John Wiley and Sons Ltd
publishDate 2014
url http://eprints.utm.my/id/eprint/62477/
http://dx.doi.org/10.1002/ptr.5193
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score 13.211869

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