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New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water

Dispersive solid phase microextraction (DSPME) is a simple and environmental friendly sample preparation technique. In DSPME, the sorbent is used for trapping the analyte/s out of the solution and then the analyte/s is to a smaller volume of a second desorption solvent. In this study, a new DSPME so...

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Main Authors: Wan Ibrahim, Wan Aini, Abd. Rahim, Mashkurah, Ramli, Zainab, Sanagi, Mohd. Marsin
Format: Conference or Workshop Item
Language:English
Published: 2014
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/61318/1/WanAiniWan2014_NewDispersiveSolidPhaseMiroextractionSorbent.pdf
http://eprints.utm.my/id/eprint/61318/
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spelling my.utm.613182017-03-31T01:28:53Z http://eprints.utm.my/id/eprint/61318/ New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water Wan Ibrahim, Wan Aini Abd. Rahim, Mashkurah Ramli, Zainab Sanagi, Mohd. Marsin QD Chemistry Dispersive solid phase microextraction (DSPME) is a simple and environmental friendly sample preparation technique. In DSPME, the sorbent is used for trapping the analyte/s out of the solution and then the analyte/s is to a smaller volume of a second desorption solvent. In this study, a new DSPME sorbent material based on a hybrid organic–inorganic methyltrimethoxysilane–cyanopropyltriethoxysilane (MTMOS–CNPrTEOS) was synthesized by using two steps sol–gel method. The new DSPME hybrid sorbent was used in determination of three selected NSAIDs namely, diclofenac sodium, ketoprofen and mefenamic acid in water samples prior to high performance liquid chromatography with ultraviolet (HPLC-UV) detection. Under the optimized conditions, the method demonstrated good linearity (0.2–500 µg L-1) with excellent coefficient of determination (r2 > 0.9991), good RSDs (<2.4%, n = 3), good limit of detection (0.03–0.12 µg L-1) and excellent recoveries (93.5–97.6%). The DSPME method using the new sol-gel hybrid MTMOS–CNPrTEOS material combined with HPLC–UV proved to be a simple, cost efficient and requires minimial amount of organic solvent that support green chemistry concepts. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/61318/1/WanAiniWan2014_NewDispersiveSolidPhaseMiroextractionSorbent.pdf Wan Ibrahim, Wan Aini and Abd. Rahim, Mashkurah and Ramli, Zainab and Sanagi, Mohd. Marsin (2014) New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water. In: 27th Regional Symposium of Analytical Sciences, 9-10 Dec, 2014, Johor Bahru, Malaysia.
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Wan Ibrahim, Wan Aini
Abd. Rahim, Mashkurah
Ramli, Zainab
Sanagi, Mohd. Marsin
New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
description Dispersive solid phase microextraction (DSPME) is a simple and environmental friendly sample preparation technique. In DSPME, the sorbent is used for trapping the analyte/s out of the solution and then the analyte/s is to a smaller volume of a second desorption solvent. In this study, a new DSPME sorbent material based on a hybrid organic–inorganic methyltrimethoxysilane–cyanopropyltriethoxysilane (MTMOS–CNPrTEOS) was synthesized by using two steps sol–gel method. The new DSPME hybrid sorbent was used in determination of three selected NSAIDs namely, diclofenac sodium, ketoprofen and mefenamic acid in water samples prior to high performance liquid chromatography with ultraviolet (HPLC-UV) detection. Under the optimized conditions, the method demonstrated good linearity (0.2–500 µg L-1) with excellent coefficient of determination (r2 > 0.9991), good RSDs (<2.4%, n = 3), good limit of detection (0.03–0.12 µg L-1) and excellent recoveries (93.5–97.6%). The DSPME method using the new sol-gel hybrid MTMOS–CNPrTEOS material combined with HPLC–UV proved to be a simple, cost efficient and requires minimial amount of organic solvent that support green chemistry concepts.
format Conference or Workshop Item
author Wan Ibrahim, Wan Aini
Abd. Rahim, Mashkurah
Ramli, Zainab
Sanagi, Mohd. Marsin
author_facet Wan Ibrahim, Wan Aini
Abd. Rahim, Mashkurah
Ramli, Zainab
Sanagi, Mohd. Marsin
author_sort Wan Ibrahim, Wan Aini
title New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
title_short New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
title_full New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
title_fullStr New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
title_full_unstemmed New dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
title_sort new dispersive solid phase miroextraction sorbent based on so-gel bybrid material for non-sterioidal anti- inflammatory drug analyis in water
publishDate 2014
url http://eprints.utm.my/id/eprint/61318/1/WanAiniWan2014_NewDispersiveSolidPhaseMiroextractionSorbent.pdf
http://eprints.utm.my/id/eprint/61318/
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score 13.211869

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