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Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery

Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have arouse special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and st...

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Main Authors: Kamarudin, Nur Hidayatul Nazirah, Abdul Jalil, Aishah, Triwahyono, Sugeng, Karim, Ainul Hakimah, Muhamad Salleh, Nur Fatien
Format: Conference or Workshop Item
Language:English
Published: 2014
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/60957/1/AishahAbdJalil2014_SynthesisofMesoporousSilicaNanoparticles.pdf
http://eprints.utm.my/id/eprint/60957/
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spelling my.utm.609572017-08-30T07:45:53Z http://eprints.utm.my/id/eprint/60957/ Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery Kamarudin, Nur Hidayatul Nazirah Abdul Jalil, Aishah Triwahyono, Sugeng Karim, Ainul Hakimah Muhamad Salleh, Nur Fatien TP Chemical technology Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have arouse special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and structure, large surface areas and pore volumes, controllable morphology and modifiable surfaces1-2. The traditional synthesis method of mesoporous materials is the hydrothermal route, which uses a certain amount of surfactants, as well as acid or alkali to compose a mixed aqueous preparation. Although finely ordered mesoporous materials are obtained, the process is time and energy consuming3. It is known that microwave (MW) heating promotes nucleation and can reduce the synthesis time and particle size significantly in comparison with the conventional convection heating method3. For the synthesis of periodic mesoporous organosilica, it was reported that the synthesis time was reduced from 72 h to 36 h when the self-assembly process was performed under MW irradiation. The resulting materials also exhibited a high surface area, large pore volume and large pore diameters4. Within this context, the microwave was utilized to synthesize the MSN under 100 W, 300 W and 450 W heating powers. Ammonia was chosen as the catalyst and ethylene glycol as the co-solvent because of their polarity, which is higher than that of NaOH and methanol or ethanol which are commonly used to synthesize mesoporous silica. All MSNs was tested for adsorption and release of an anti-inflammatory and anti-cancer drug, ibuprofen. The characterization revealed that the MSN prepared under 450 W (MSN450) produced the most crystallized and prominent mesoporous structure compared to lower power applied (Figure 1). MSN450 exhibited the highest ibuprofen adsorption, followed by MSN300 and MSN100, confirming that more crystallized MSN demonstrated higher adsorptivity toward ibuprofen. For the release study, MSN450 showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. All MSNs was found to exhibit good activity for the ibuprofen adsorption and release. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/60957/1/AishahAbdJalil2014_SynthesisofMesoporousSilicaNanoparticles.pdf Kamarudin, Nur Hidayatul Nazirah and Abdul Jalil, Aishah and Triwahyono, Sugeng and Karim, Ainul Hakimah and Muhamad Salleh, Nur Fatien (2014) Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery. In: 27th Regional Symposium of Malaysia Analytical Sciences, 8-10 Dec, 2014, Johor Bahru, Malaysia.
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Karim, Ainul Hakimah
Muhamad Salleh, Nur Fatien
Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
description Mesoporous silica nanoparticles (MSN), which combine both unique properties of nanomaterials and mesostructured substances, have arouse special attention in biomedical research field due to its great advantages in many aspects such as well biocompatible, unique properties of tunable pore size and structure, large surface areas and pore volumes, controllable morphology and modifiable surfaces1-2. The traditional synthesis method of mesoporous materials is the hydrothermal route, which uses a certain amount of surfactants, as well as acid or alkali to compose a mixed aqueous preparation. Although finely ordered mesoporous materials are obtained, the process is time and energy consuming3. It is known that microwave (MW) heating promotes nucleation and can reduce the synthesis time and particle size significantly in comparison with the conventional convection heating method3. For the synthesis of periodic mesoporous organosilica, it was reported that the synthesis time was reduced from 72 h to 36 h when the self-assembly process was performed under MW irradiation. The resulting materials also exhibited a high surface area, large pore volume and large pore diameters4. Within this context, the microwave was utilized to synthesize the MSN under 100 W, 300 W and 450 W heating powers. Ammonia was chosen as the catalyst and ethylene glycol as the co-solvent because of their polarity, which is higher than that of NaOH and methanol or ethanol which are commonly used to synthesize mesoporous silica. All MSNs was tested for adsorption and release of an anti-inflammatory and anti-cancer drug, ibuprofen. The characterization revealed that the MSN prepared under 450 W (MSN450) produced the most crystallized and prominent mesoporous structure compared to lower power applied (Figure 1). MSN450 exhibited the highest ibuprofen adsorption, followed by MSN300 and MSN100, confirming that more crystallized MSN demonstrated higher adsorptivity toward ibuprofen. For the release study, MSN450 showed the slowest release rate of ibuprofen, followed by MSN300 and MSN100. All MSNs was found to exhibit good activity for the ibuprofen adsorption and release.
format Conference or Workshop Item
author Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Karim, Ainul Hakimah
Muhamad Salleh, Nur Fatien
author_facet Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Karim, Ainul Hakimah
Muhamad Salleh, Nur Fatien
author_sort Kamarudin, Nur Hidayatul Nazirah
title Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
title_short Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
title_full Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
title_fullStr Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
title_full_unstemmed Synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
title_sort synthesis of mesoporous silica nanoparticles by variation of microwave power for the ibuprofen drug delivery
publishDate 2014
url http://eprints.utm.my/id/eprint/60957/1/AishahAbdJalil2014_SynthesisofMesoporousSilicaNanoparticles.pdf
http://eprints.utm.my/id/eprint/60957/
_version_ 1643655027784417280
score 13.211869

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