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Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers

Fluorescent molecules are commonly used for the detection of disease biomarkers. Metal Enhanced Fluorescence (MEF) is a promising strategy for improving the detection sensitivity. This paper describes current research on using Computational Electromagnetics (CEM) as a prediction tool for fluorescent...

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Main Authors: Centeno, Anthony Edward Robert, Xie, Fang
Format: Article
Published: AMG Transcend Association 2014
Subjects:
Q Science (General)
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.utm.my/id/eprint/60019/
https://biointerfaceresearch.com/?page_id=656
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id my.utm.60019
record_format eprints
spelling my.utm.600192022-01-16T07:30:38Z http://eprints.utm.my/id/eprint/60019/ Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers Centeno, Anthony Edward Robert Xie, Fang Q Science (General) TA Engineering (General). Civil engineering (General) Fluorescent molecules are commonly used for the detection of disease biomarkers. Metal Enhanced Fluorescence (MEF) is a promising strategy for improving the detection sensitivity. This paper describes current research on using Computational Electromagnetics (CEM) as a prediction tool for fluorescent enhancement. Recent published work has shown that for isolated spherical nanoparticles in solution fluorescent enhancement can be predicted with reasonably good accuracy. This work has been extended to consider immobilized particles in periodic arrays formed by colloidal lithography. These kinds of arrays could have potential applications in sensing and bioimaging. The initial results show that coupling between the fluorophore and the metal nanoparticle is extremely complex. The coupling is strongly dependent on the position and electromagnetic polarization of the fluorophore emission with respect to the adjacent metal surface. AMG Transcend Association 2014 Article PeerReviewed Centeno, Anthony Edward Robert and Xie, Fang (2014) Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers. Biointerface Research in Applied Chemistry, 4 (3). pp. 731-735. ISSN 2069-5837 https://biointerfaceresearch.com/?page_id=656
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
TA Engineering (General). Civil engineering (General)
spellingShingle Q Science (General)
TA Engineering (General). Civil engineering (General)
Centeno, Anthony Edward Robert
Xie, Fang
Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
description Fluorescent molecules are commonly used for the detection of disease biomarkers. Metal Enhanced Fluorescence (MEF) is a promising strategy for improving the detection sensitivity. This paper describes current research on using Computational Electromagnetics (CEM) as a prediction tool for fluorescent enhancement. Recent published work has shown that for isolated spherical nanoparticles in solution fluorescent enhancement can be predicted with reasonably good accuracy. This work has been extended to consider immobilized particles in periodic arrays formed by colloidal lithography. These kinds of arrays could have potential applications in sensing and bioimaging. The initial results show that coupling between the fluorophore and the metal nanoparticle is extremely complex. The coupling is strongly dependent on the position and electromagnetic polarization of the fluorophore emission with respect to the adjacent metal surface.
format Article
author Centeno, Anthony Edward Robert
Xie, Fang
author_facet Centeno, Anthony Edward Robert
Xie, Fang
author_sort Centeno, Anthony Edward Robert
title Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
title_short Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
title_full Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
title_fullStr Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
title_full_unstemmed Towards optimizing metal enhanced fluorescence (MEF) for improved detection of disease biomarkers
title_sort towards optimizing metal enhanced fluorescence (mef) for improved detection of disease biomarkers
publisher AMG Transcend Association
publishDate 2014
url http://eprints.utm.my/id/eprint/60019/
https://biointerfaceresearch.com/?page_id=656
_version_ 1724073251639918592
score 13.211869

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