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Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion

Ficus deltoidea from the Moraceae family is a popular medicinal herb in Malaysia. It possesses strong antioxidant and anti- inflammatory properties. In the present study, the anti-inflammatory effects of F. deltoidea extract on UVB-irradiated HaCaT Keratinocytes were investigated. HaCaT Keratinocyte...

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Main Authors: Hasham @ Hisam, Rosnani, Choi, Hyun Kyung, Park, Chang Seo
Format: Article
Published: World Academy of Science, Engineering and Technology 2014
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/59755/
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spelling my.utm.597552022-02-21T08:09:22Z http://eprints.utm.my/id/eprint/59755/ Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion Hasham @ Hisam, Rosnani Choi, Hyun Kyung Park, Chang Seo Q Science (General) Ficus deltoidea from the Moraceae family is a popular medicinal herb in Malaysia. It possesses strong antioxidant and anti- inflammatory properties. In the present study, the anti-inflammatory effects of F. deltoidea extract on UVB-irradiated HaCaT Keratinocytes were investigated. HaCaT Keratinocytes were UVB- irradiated (12.5 mJ/cm3 ) and were treated with 0.05, 0.08 or 0.1% of F. deltoidea extract. Cell viability following UVB irradiation was significantly higher in the groups treated with the F. deltoidea extract at doses of 0.05, 0.08 or 0.1% than in control group with UVB irradiation only. Tumor necrosis factor-α (TNF-α), interleukin-1 α (IL-1α), interleukin-6 (IL-6) and cyclooxygenase (COX-2) play primary roles in the inflammation process upon UV irradiation and are known to be stimulated by UVB irradiation. Treatment with the F. deltoidea extract dramatically inhibited the UV-induced TNF-α, IL-1α, IL-6, and COX-2 expression. These results suggest that the F. deltoidea extract inhibits the production of pro-inflammatory cytokines and may be an effective protective agent for the treatment of skin diseases. World Academy of Science, Engineering and Technology 2014 Article PeerReviewed Hasham @ Hisam, Rosnani and Choi, Hyun Kyung and Park, Chang Seo (2014) Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion. International Journal of Biological, Veterinary, Agricultural and Food Engineering, 8 (11). pp. 1046-1050. ISSN 1307-6892
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Hasham @ Hisam, Rosnani
Choi, Hyun Kyung
Park, Chang Seo
Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
description Ficus deltoidea from the Moraceae family is a popular medicinal herb in Malaysia. It possesses strong antioxidant and anti- inflammatory properties. In the present study, the anti-inflammatory effects of F. deltoidea extract on UVB-irradiated HaCaT Keratinocytes were investigated. HaCaT Keratinocytes were UVB- irradiated (12.5 mJ/cm3 ) and were treated with 0.05, 0.08 or 0.1% of F. deltoidea extract. Cell viability following UVB irradiation was significantly higher in the groups treated with the F. deltoidea extract at doses of 0.05, 0.08 or 0.1% than in control group with UVB irradiation only. Tumor necrosis factor-α (TNF-α), interleukin-1 α (IL-1α), interleukin-6 (IL-6) and cyclooxygenase (COX-2) play primary roles in the inflammation process upon UV irradiation and are known to be stimulated by UVB irradiation. Treatment with the F. deltoidea extract dramatically inhibited the UV-induced TNF-α, IL-1α, IL-6, and COX-2 expression. These results suggest that the F. deltoidea extract inhibits the production of pro-inflammatory cytokines and may be an effective protective agent for the treatment of skin diseases.
format Article
author Hasham @ Hisam, Rosnani
Choi, Hyun Kyung
Park, Chang Seo
author_facet Hasham @ Hisam, Rosnani
Choi, Hyun Kyung
Park, Chang Seo
author_sort Hasham @ Hisam, Rosnani
title Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
title_short Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
title_full Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
title_fullStr Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
title_full_unstemmed Ficus deltoidea extract protects HaCaT keratinocyctes from UVB irradition-induced inflammtion
title_sort ficus deltoidea extract protects hacat keratinocyctes from uvb irradition-induced inflammtion
publisher World Academy of Science, Engineering and Technology
publishDate 2014
url http://eprints.utm.my/id/eprint/59755/
_version_ 1725972654072004608
score 13.211869

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