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Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys

The role of honeys as chemopreventive agents was inferred from their phenolic composition. The present study aims to isolate and identify such phenolic compounds with anticarcinogenic potential from the sugar matrix of Malaysian honeys. Phenolic compounds in Malaysian Acacia, Gelam and Tualang honey...

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Main Authors: Ismail, Norjihada Izzah, Abdul Kadir, Mohammed Rafiq, Mohamed Zulkifli, Razauden
Format: Article
Published: Open Science Publishers LLP Inc. 2015
Subjects:
R Medicine (General)
Online Access:http://eprints.utm.my/id/eprint/58453/
http://dx.doi.org/10.7324/JAPS.2015.501011
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spelling my.utm.584532017-09-18T01:28:16Z http://eprints.utm.my/id/eprint/58453/ Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys Ismail, Norjihada Izzah Abdul Kadir, Mohammed Rafiq Mohamed Zulkifli, Razauden R Medicine (General) The role of honeys as chemopreventive agents was inferred from their phenolic composition. The present study aims to isolate and identify such phenolic compounds with anticarcinogenic potential from the sugar matrix of Malaysian honeys. Phenolic compounds in Malaysian Acacia, Gelam and Tualang honey samples were isolated using octadecyl (C18) silica solid phase extraction (SPE) technique and identification was performed using high-performance liquid chromatography (HPLC) with diode array detector (DAD). Identification of phenolic compounds was achieved by comparing chromatographic retention times of honey samples with those of authentic standard compounds. HPLC analysis confirmed the presence of anticancer phenolic compounds in all honey samples with considerable variation observed among both different and the same types of honey. Six flavonoids (quercetin, naringenin, kaempferol, rutin, hesperetin, and apigenin), two phenolic acids (p-coumaric acid, and ferulic acid) and two tannins (ellagic acid, and penta-O-galloyl-ß-D-glucose [PGG]) were the bioactive anticancer compounds identified. The presence of PGG in Malaysian honey was described for the first time. This study concludes that these three types of Malaysian honey possessed anticancer properties at varying degrees. Their potential usage as natural anticancer therapeutic agents with numerous health benefits could be further explored and considered as an alternative for current anticancer drugs Open Science Publishers LLP Inc. 2015 Article PeerReviewed Ismail, Norjihada Izzah and Abdul Kadir, Mohammed Rafiq and Mohamed Zulkifli, Razauden (2015) Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys. Journal of Applied Pharmaceutical Science, 5 (10). pp. 59-66. ISSN 2231-3354 http://dx.doi.org/10.7324/JAPS.2015.501011 DOI:10.7324/JAPS.2015.501011
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Ismail, Norjihada Izzah
Abdul Kadir, Mohammed Rafiq
Mohamed Zulkifli, Razauden
Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
description The role of honeys as chemopreventive agents was inferred from their phenolic composition. The present study aims to isolate and identify such phenolic compounds with anticarcinogenic potential from the sugar matrix of Malaysian honeys. Phenolic compounds in Malaysian Acacia, Gelam and Tualang honey samples were isolated using octadecyl (C18) silica solid phase extraction (SPE) technique and identification was performed using high-performance liquid chromatography (HPLC) with diode array detector (DAD). Identification of phenolic compounds was achieved by comparing chromatographic retention times of honey samples with those of authentic standard compounds. HPLC analysis confirmed the presence of anticancer phenolic compounds in all honey samples with considerable variation observed among both different and the same types of honey. Six flavonoids (quercetin, naringenin, kaempferol, rutin, hesperetin, and apigenin), two phenolic acids (p-coumaric acid, and ferulic acid) and two tannins (ellagic acid, and penta-O-galloyl-ß-D-glucose [PGG]) were the bioactive anticancer compounds identified. The presence of PGG in Malaysian honey was described for the first time. This study concludes that these three types of Malaysian honey possessed anticancer properties at varying degrees. Their potential usage as natural anticancer therapeutic agents with numerous health benefits could be further explored and considered as an alternative for current anticancer drugs
format Article
author Ismail, Norjihada Izzah
Abdul Kadir, Mohammed Rafiq
Mohamed Zulkifli, Razauden
author_facet Ismail, Norjihada Izzah
Abdul Kadir, Mohammed Rafiq
Mohamed Zulkifli, Razauden
author_sort Ismail, Norjihada Izzah
title Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
title_short Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
title_full Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
title_fullStr Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
title_full_unstemmed Isolation and identification of potential antineoplastic bioactive phenolic compounds in Malaysian honeys
title_sort isolation and identification of potential antineoplastic bioactive phenolic compounds in malaysian honeys
publisher Open Science Publishers LLP Inc.
publishDate 2015
url http://eprints.utm.my/id/eprint/58453/
http://dx.doi.org/10.7324/JAPS.2015.501011
_version_ 1643654281708961792
score 13.211869

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