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Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers

Poly(ε-caprolactone)/chitosan (PCL/chitosan) blend nanofibers with different ratios of chitosan were electrospun from a formic acid/acetic acid (FA/AA) solvent system. Bovine serum albumin (BSA) was used as a model protein to incorporate biochemical cues into the nanofibrous scaffolds. The morpholog...

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Main Authors: Roozbahani, Fatemeh, Sultana, Naznin, Almasi, Davood, Naghizadeh, Farnaz
Format: Article
Published: Hindawi 2015
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/58416/
http://www.dx.doi.org/10.1155/2015/747420
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spelling my.utm.584162022-02-08T02:57:59Z http://eprints.utm.my/id/eprint/58416/ Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers Roozbahani, Fatemeh Sultana, Naznin Almasi, Davood Naghizadeh, Farnaz Q Science (General) Poly(ε-caprolactone)/chitosan (PCL/chitosan) blend nanofibers with different ratios of chitosan were electrospun from a formic acid/acetic acid (FA/AA) solvent system. Bovine serum albumin (BSA) was used as a model protein to incorporate biochemical cues into the nanofibrous scaffolds. The morphological characteristics of PCL/chitosan and PCL/chitosan/BSA Nanofibers were investigated by scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) was used to detect the presence of polymeric ingredients and BSA in the Nanofibers. The effects of the polymer blend ratio and BSA concentration on the morphological characteristics and consequently on the BSA release pattern were evaluated. The average fiber diameter and pore size were greater in Nanofibers containing BSA. The chitosan ratio played a significant role in the BSA release profile from the PCL/chitosan/BSA blend. Nanofibrous scaffolds with higher chitosan ratios exhibited less intense bursts in the BSA release profile. Hindawi 2015 Article PeerReviewed Roozbahani, Fatemeh and Sultana, Naznin and Almasi, Davood and Naghizadeh, Farnaz (2015) Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers. Journal of Nanomaterials, 2015 . ISSN 1687-4110 http://www.dx.doi.org/10.1155/2015/747420 DOI: 10.1155/2015/747420
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Roozbahani, Fatemeh
Sultana, Naznin
Almasi, Davood
Naghizadeh, Farnaz
Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
description Poly(ε-caprolactone)/chitosan (PCL/chitosan) blend nanofibers with different ratios of chitosan were electrospun from a formic acid/acetic acid (FA/AA) solvent system. Bovine serum albumin (BSA) was used as a model protein to incorporate biochemical cues into the nanofibrous scaffolds. The morphological characteristics of PCL/chitosan and PCL/chitosan/BSA Nanofibers were investigated by scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) was used to detect the presence of polymeric ingredients and BSA in the Nanofibers. The effects of the polymer blend ratio and BSA concentration on the morphological characteristics and consequently on the BSA release pattern were evaluated. The average fiber diameter and pore size were greater in Nanofibers containing BSA. The chitosan ratio played a significant role in the BSA release profile from the PCL/chitosan/BSA blend. Nanofibrous scaffolds with higher chitosan ratios exhibited less intense bursts in the BSA release profile.
format Article
author Roozbahani, Fatemeh
Sultana, Naznin
Almasi, Davood
Naghizadeh, Farnaz
author_facet Roozbahani, Fatemeh
Sultana, Naznin
Almasi, Davood
Naghizadeh, Farnaz
author_sort Roozbahani, Fatemeh
title Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
title_short Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
title_full Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
title_fullStr Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
title_full_unstemmed Effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
title_sort effects of chitosan concentration on the protein release behaviour of electrospun poly(epsilon-caprolactone)/chitosan nanofibers
publisher Hindawi
publishDate 2015
url http://eprints.utm.my/id/eprint/58416/
http://www.dx.doi.org/10.1155/2015/747420
_version_ 1724607965895327744
score 13.211869

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