Staff View: Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells

Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells

Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailmen...

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Main Authors:	Basar, Norazah, Oridupa, Olayinka Ayotunde, Ritchie, Kenneth J., Nahar, Lutfun, Osman, Nashwa Mostafa M., Stafford, Angela, Kushiev, Habibjon, Kan, Asuman, Sarker, Satyajit D.
Format:	Article
Published:	John Wiley and Sons Ltd 2015
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/58095/ http://dx.doi.org/10.1002/ptr.5329
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spelling	my.utm.580952021-12-13T07:56:20Z http://eprints.utm.my/id/eprint/58095/ Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells Basar, Norazah Oridupa, Olayinka Ayotunde Ritchie, Kenneth J. Nahar, Lutfun Osman, Nashwa Mostafa M. Stafford, Angela Kushiev, Habibjon Kan, Asuman Sarker, Satyajit D. QD Chemistry Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G.-glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G.-glabra. John Wiley and Sons Ltd 2015 Article PeerReviewed Basar, Norazah and Oridupa, Olayinka Ayotunde and Ritchie, Kenneth J. and Nahar, Lutfun and Osman, Nashwa Mostafa M. and Stafford, Angela and Kushiev, Habibjon and Kan, Asuman and Sarker, Satyajit D. (2015) Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells. Phytotherapy Research, 29 (6). pp. 944-948. ISSN 0951-418X http://dx.doi.org/10.1002/ptr.5329 DOI:10.1002/ptr.5329
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Basar, Norazah Oridupa, Olayinka Ayotunde Ritchie, Kenneth J. Nahar, Lutfun Osman, Nashwa Mostafa M. Stafford, Angela Kushiev, Habibjon Kan, Asuman Sarker, Satyajit D. Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
description	Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G.-glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G.-glabra.
format	Article
author	Basar, Norazah Oridupa, Olayinka Ayotunde Ritchie, Kenneth J. Nahar, Lutfun Osman, Nashwa Mostafa M. Stafford, Angela Kushiev, Habibjon Kan, Asuman Sarker, Satyajit D.
author_facet	Basar, Norazah Oridupa, Olayinka Ayotunde Ritchie, Kenneth J. Nahar, Lutfun Osman, Nashwa Mostafa M. Stafford, Angela Kushiev, Habibjon Kan, Asuman Sarker, Satyajit D.
author_sort	Basar, Norazah
title	Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
title_short	Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
title_full	Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
title_fullStr	Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
title_full_unstemmed	Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells
title_sort	comparative cytotoxicity of glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (hacat), lung adenocarcinoma (a549) and liver carcinoma (hepg2) cells
publisher	John Wiley and Sons Ltd
publishDate	2015
url	http://eprints.utm.my/id/eprint/58095/ http://dx.doi.org/10.1002/ptr.5329
_version_	1720436862758158336
score	13.211869

Comparative cytotoxicity of Glycyrrhiza glabra roots from different geographical origins against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cells

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