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Chitosan-based nanocomposite scaffolds for tissue engineering applications

This article reports the fabrication of three-dimensional porous chitosan and hydroxyapatite (HA)/chitosan composite scaffolds by the thermally induced phase separation (TIPS) technique, for bone tissue engineering. Different amounts of HA nanoparticles (10%, 20%, and 30% g/g) were added to the chit...

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Main Authors: Sultana, Naznin, Mokhtar, Masturah, Hassan, Mohd. Izzat, Jin, Rashid Mad, Roozbahani, Fatemeh, Khan, Tareef Hayat
Format: Article
Published: Taylor and Francis Inc. 2015
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/58048/
http://dx.doi.org/10.1080/10426914.2014.892610
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spelling my.utm.580482021-08-23T01:02:05Z http://eprints.utm.my/id/eprint/58048/ Chitosan-based nanocomposite scaffolds for tissue engineering applications Sultana, Naznin Mokhtar, Masturah Hassan, Mohd. Izzat Jin, Rashid Mad Roozbahani, Fatemeh Khan, Tareef Hayat TP Chemical technology This article reports the fabrication of three-dimensional porous chitosan and hydroxyapatite (HA)/chitosan composite scaffolds by the thermally induced phase separation (TIPS) technique, for bone tissue engineering. Different amounts of HA nanoparticles (10%, 20%, and 30% g/g) were added to the chitosan solution to produce HA/chitosan composite scaffolds of varying compositions. The morphology and pore structure of the scaffolds vis-à-vis composition were characterized using scanning electron microscopy (SEM) and an energy dispersive X-ray (EDX). Both pure chitosan and HA/chitosan composite scaffolds were highly porous and had interconnected pores. The pore sizes ranged from several micrometers to a few hundred micrometers. The HA nanoparticles were well dispersed and physically coexisted with chitosan in the composite scaffolds. However, some agglomeration of HA nanoparticles was observed on the surface of pore walls when a relatively large amount of HA was used. The composite 3D scaffolds are very promising for use in bone tissue engineering application. Taylor and Francis Inc. 2015-03-04 Article PeerReviewed Sultana, Naznin and Mokhtar, Masturah and Hassan, Mohd. Izzat and Jin, Rashid Mad and Roozbahani, Fatemeh and Khan, Tareef Hayat (2015) Chitosan-based nanocomposite scaffolds for tissue engineering applications. Materials And Manufacturing Processes, 30 (3). pp. 273-278. ISSN 1042-6914 http://dx.doi.org/10.1080/10426914.2014.892610 DOI:10.1080/10426914.2014.892610
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Sultana, Naznin
Mokhtar, Masturah
Hassan, Mohd. Izzat
Jin, Rashid Mad
Roozbahani, Fatemeh
Khan, Tareef Hayat
Chitosan-based nanocomposite scaffolds for tissue engineering applications
description This article reports the fabrication of three-dimensional porous chitosan and hydroxyapatite (HA)/chitosan composite scaffolds by the thermally induced phase separation (TIPS) technique, for bone tissue engineering. Different amounts of HA nanoparticles (10%, 20%, and 30% g/g) were added to the chitosan solution to produce HA/chitosan composite scaffolds of varying compositions. The morphology and pore structure of the scaffolds vis-à-vis composition were characterized using scanning electron microscopy (SEM) and an energy dispersive X-ray (EDX). Both pure chitosan and HA/chitosan composite scaffolds were highly porous and had interconnected pores. The pore sizes ranged from several micrometers to a few hundred micrometers. The HA nanoparticles were well dispersed and physically coexisted with chitosan in the composite scaffolds. However, some agglomeration of HA nanoparticles was observed on the surface of pore walls when a relatively large amount of HA was used. The composite 3D scaffolds are very promising for use in bone tissue engineering application.
format Article
author Sultana, Naznin
Mokhtar, Masturah
Hassan, Mohd. Izzat
Jin, Rashid Mad
Roozbahani, Fatemeh
Khan, Tareef Hayat
author_facet Sultana, Naznin
Mokhtar, Masturah
Hassan, Mohd. Izzat
Jin, Rashid Mad
Roozbahani, Fatemeh
Khan, Tareef Hayat
author_sort Sultana, Naznin
title Chitosan-based nanocomposite scaffolds for tissue engineering applications
title_short Chitosan-based nanocomposite scaffolds for tissue engineering applications
title_full Chitosan-based nanocomposite scaffolds for tissue engineering applications
title_fullStr Chitosan-based nanocomposite scaffolds for tissue engineering applications
title_full_unstemmed Chitosan-based nanocomposite scaffolds for tissue engineering applications
title_sort chitosan-based nanocomposite scaffolds for tissue engineering applications
publisher Taylor and Francis Inc.
publishDate 2015
url http://eprints.utm.my/id/eprint/58048/
http://dx.doi.org/10.1080/10426914.2014.892610
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score 13.211869

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