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Chemical compositions and biological activities of essential oils of Beilschmiedia glabra

This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in the essential oils, which made up 86.8% and...

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Main Authors: Wan Salleh, Wan Mohd. Nuzul Hakimi, Ahmad, Farediah, Yen, Khong Heng, Zulkifli, Razauden Mohamed
Format: Article
Language:English
Published: Natural Product Incorporation 2015
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/58042/1/WanMohd2015_ChemicalCompositionsandBiologicalActivities.pdf
http://eprints.utm.my/id/eprint/58042/
http://dx.doi.org/10.1177/1934578x1501000740
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spelling my.utm.580422021-12-09T03:19:43Z http://eprints.utm.my/id/eprint/58042/ Chemical compositions and biological activities of essential oils of Beilschmiedia glabra Wan Salleh, Wan Mohd. Nuzul Hakimi Ahmad, Farediah Yen, Khong Heng Zulkifli, Razauden Mohamed QD Chemistry This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in the essential oils, which made up 86.8% and 89.7% of the leaf and bark oils, respectively. The leaf oil is composed mainly of β-eudesmol (15.4%), β-selinene (12.2%), caryophyllene oxide (8.1%) and γ-gurjunene (5.2%), while the bark oil contains high percentages of β-eudesmol (19.3%), β-selinene (16.9%), δ-cadinene (15.8%), germacrene D (9.8%) and β-caryophyllene (5.5%). Antioxidant activity showed that the leaf oil has the highest phenolic content at 233.4 mg GA/g, while the bark oil showed potent activity in the β- carotene/linoleic acid bleaching assay. However, both oils showed weak activity in the DPPH and ABTS assays. For antimicrobial activity, the leaf and bark oils displayed strong activity against Candida glabrata and Saccharomyces cerevisiae with MIC values of 31.3 and 62.5 μg/mL, respectively. Percentage inhibitions against tyrosinase (leaf 73.7%; bark 76.0%) and acetylcholinesterase (leaf 48.1%; bark 45.2%) were tested at a concentration of 1 mg/mL, while anti-inflammatory activity (leaf 59.7%; bark 48.9%) was evaluated at a concentration of 100 μM. Evaluation of these assays indicated moderate levels of activity. Natural Product Incorporation 2015 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/58042/1/WanMohd2015_ChemicalCompositionsandBiologicalActivities.pdf Wan Salleh, Wan Mohd. Nuzul Hakimi and Ahmad, Farediah and Yen, Khong Heng and Zulkifli, Razauden Mohamed (2015) Chemical compositions and biological activities of essential oils of Beilschmiedia glabra. Natural Product Communications, 10 (7). pp. 1297-1300. ISSN 1934-578X http://dx.doi.org/10.1177/1934578x1501000740 DOI:10.1177/1934578x1501000740
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Wan Salleh, Wan Mohd. Nuzul Hakimi
Ahmad, Farediah
Yen, Khong Heng
Zulkifli, Razauden Mohamed
Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
description This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in the essential oils, which made up 86.8% and 89.7% of the leaf and bark oils, respectively. The leaf oil is composed mainly of β-eudesmol (15.4%), β-selinene (12.2%), caryophyllene oxide (8.1%) and γ-gurjunene (5.2%), while the bark oil contains high percentages of β-eudesmol (19.3%), β-selinene (16.9%), δ-cadinene (15.8%), germacrene D (9.8%) and β-caryophyllene (5.5%). Antioxidant activity showed that the leaf oil has the highest phenolic content at 233.4 mg GA/g, while the bark oil showed potent activity in the β- carotene/linoleic acid bleaching assay. However, both oils showed weak activity in the DPPH and ABTS assays. For antimicrobial activity, the leaf and bark oils displayed strong activity against Candida glabrata and Saccharomyces cerevisiae with MIC values of 31.3 and 62.5 μg/mL, respectively. Percentage inhibitions against tyrosinase (leaf 73.7%; bark 76.0%) and acetylcholinesterase (leaf 48.1%; bark 45.2%) were tested at a concentration of 1 mg/mL, while anti-inflammatory activity (leaf 59.7%; bark 48.9%) was evaluated at a concentration of 100 μM. Evaluation of these assays indicated moderate levels of activity.
format Article
author Wan Salleh, Wan Mohd. Nuzul Hakimi
Ahmad, Farediah
Yen, Khong Heng
Zulkifli, Razauden Mohamed
author_facet Wan Salleh, Wan Mohd. Nuzul Hakimi
Ahmad, Farediah
Yen, Khong Heng
Zulkifli, Razauden Mohamed
author_sort Wan Salleh, Wan Mohd. Nuzul Hakimi
title Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
title_short Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
title_full Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
title_fullStr Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
title_full_unstemmed Chemical compositions and biological activities of essential oils of Beilschmiedia glabra
title_sort chemical compositions and biological activities of essential oils of beilschmiedia glabra
publisher Natural Product Incorporation
publishDate 2015
url http://eprints.utm.my/id/eprint/58042/1/WanMohd2015_ChemicalCompositionsandBiologicalActivities.pdf
http://eprints.utm.my/id/eprint/58042/
http://dx.doi.org/10.1177/1934578x1501000740
_version_ 1720436861040590848
score 13.211869

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