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Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones

Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones. Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin...

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Main Authors:	Nadri, Muhammad Helmi, Abu Naser, Mohammed, Zukifli, Razauden Mohamed, Muhamad, Ida Idayu, Ahmad, Farediah, Wan Salleh, Wan Mohd. Nuzul Hakimi, Sirat, Hasnah M.
Format:	Article
Published:	2015
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/57837/ http://dx.doi.org/10.4314/ajtcam.v12i2.18
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id	my.utm.57837
record_format	eprints
spelling	my.utm.578372021-11-09T06:47:10Z http://eprints.utm.my/id/eprint/57837/ Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones Nadri, Muhammad Helmi Abu Naser, Mohammed Zukifli, Razauden Mohamed Muhamad, Ida Idayu Ahmad, Farediah Wan Salleh, Wan Mohd. Nuzul Hakimi Sirat, Hasnah M. Q Science (General) Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones. Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively. Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations. Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations. 2015 Article PeerReviewed Nadri, Muhammad Helmi and Abu Naser, Mohammed and Zukifli, Razauden Mohamed and Muhamad, Ida Idayu and Ahmad, Farediah and Wan Salleh, Wan Mohd. Nuzul Hakimi and Sirat, Hasnah M. (2015) Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones. African Journal of Traditional Complementary And Altertive Medicines, 12 (2). pp. 120-125. ISSN 1882-0743 http://dx.doi.org/10.4314/ajtcam.v12i2.18 DOI: 10.4314/ajtcam.v12i2.18
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	Q Science (General)
spellingShingle	Q Science (General) Nadri, Muhammad Helmi Abu Naser, Mohammed Zukifli, Razauden Mohamed Muhamad, Ida Idayu Ahmad, Farediah Wan Salleh, Wan Mohd. Nuzul Hakimi Sirat, Hasnah M. Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
description	Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones. Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively. Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations. Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations.
format	Article
author	Nadri, Muhammad Helmi Abu Naser, Mohammed Zukifli, Razauden Mohamed Muhamad, Ida Idayu Ahmad, Farediah Wan Salleh, Wan Mohd. Nuzul Hakimi Sirat, Hasnah M.
author_facet	Nadri, Muhammad Helmi Abu Naser, Mohammed Zukifli, Razauden Mohamed Muhamad, Ida Idayu Ahmad, Farediah Wan Salleh, Wan Mohd. Nuzul Hakimi Sirat, Hasnah M.
author_sort	Nadri, Muhammad Helmi
title	Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
title_short	Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
title_full	Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
title_fullStr	Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
title_full_unstemmed	Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
title_sort	antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones
publishDate	2015
url	http://eprints.utm.my/id/eprint/57837/ http://dx.doi.org/10.4314/ajtcam.v12i2.18
_version_	1717093380547149824
score	13.211869

Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones

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