Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker

Genipin, a natural and non-toxic cross linker, was used to prepare cross linked floating kappa carrageenan/sodium carboxymethyl cellulose hydrogels and the effect of genipin on hydrogels characterization was investigated. Calcium carbonates were employed as gas forming agents. Ranitidine hydrochlori...

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Main Authors: Selvakumaran, Suguna, Muhamad, Ida Idayu
Format: Article
Published: Elsevier 2015
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Online Access:http://eprints.utm.my/id/eprint/55097/
http://dx.doi.org/10.1016/j.ijpharm.2015.10.005
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spelling my.utm.550972017-02-15T07:36:17Z http://eprints.utm.my/id/eprint/55097/ Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker Selvakumaran, Suguna Muhamad, Ida Idayu R Medicine (General) Genipin, a natural and non-toxic cross linker, was used to prepare cross linked floating kappa carrageenan/sodium carboxymethyl cellulose hydrogels and the effect of genipin on hydrogels characterization was investigated. Calcium carbonates were employed as gas forming agents. Ranitidine hydrochloride was used as drug. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were carried out to study the changes in the characteristics of hydrogels. Furthermore, scanning electron microscope (SEM) was performed to study microstructure of hydrogels. The result showed that all formulated hydrogels had excellent floating behavior. It was discovered that the cross linking reaction showed significant effect on gel strength, porosity and swelling ratio compared to non-cross linked hydrogels. It was found that the drug release was slower and lesser after being cross linked. Microstructure study shows that cross linked hydrogels exhibited hard and rough surface. Therefore, genipin can be an interesting cross linking agent for controlled drug delivery in gastrointestinal tract. Elsevier 2015-12 Article PeerReviewed Selvakumaran, Suguna and Muhamad, Ida Idayu (2015) Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker. International Journal of Pharmaceutics, 469 (2). pp. 323-331. ISSN 0378-5173 http://dx.doi.org/10.1016/j.ijpharm.2015.10.005 DOI:10.1016/j.ijpharm.2015.10.005
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Selvakumaran, Suguna
Muhamad, Ida Idayu
Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
description Genipin, a natural and non-toxic cross linker, was used to prepare cross linked floating kappa carrageenan/sodium carboxymethyl cellulose hydrogels and the effect of genipin on hydrogels characterization was investigated. Calcium carbonates were employed as gas forming agents. Ranitidine hydrochloride was used as drug. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were carried out to study the changes in the characteristics of hydrogels. Furthermore, scanning electron microscope (SEM) was performed to study microstructure of hydrogels. The result showed that all formulated hydrogels had excellent floating behavior. It was discovered that the cross linking reaction showed significant effect on gel strength, porosity and swelling ratio compared to non-cross linked hydrogels. It was found that the drug release was slower and lesser after being cross linked. Microstructure study shows that cross linked hydrogels exhibited hard and rough surface. Therefore, genipin can be an interesting cross linking agent for controlled drug delivery in gastrointestinal tract.
format Article
author Selvakumaran, Suguna
Muhamad, Ida Idayu
author_facet Selvakumaran, Suguna
Muhamad, Ida Idayu
author_sort Selvakumaran, Suguna
title Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
title_short Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
title_full Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
title_fullStr Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
title_full_unstemmed Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
title_sort evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker
publisher Elsevier
publishDate 2015
url http://eprints.utm.my/id/eprint/55097/
http://dx.doi.org/10.1016/j.ijpharm.2015.10.005
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score 13.211869