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Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles

Mesoporous silica nanoparticles (MSN) with 1-10 wt% loading of aluminum (Al) were prepared and characterized by XRD, N-2 physisorption, Si-29 and Al-27 NMR, FT-IR and FT-IR preadsorbed pyridine. All samples were evaluated for ibuprofen adsorption and release. The results showed that MSN gave almost...

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Main Authors: Kamarudin, Nur Hidayatul Nazirah, Abdul Jalil, Aishah, Triwahyono, Sugeng, Sazegar, Mohammad Reza, Hamdan, Salehhuddin, Baba, Sayang, Ahmad, Arshad
Format: Article
Published: Royal SOC Chemistry 2015
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/54968/
http://dx.doi.org/10.1039/c4ra16761a
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spelling my.utm.549682017-07-31T07:07:08Z http://eprints.utm.my/id/eprint/54968/ Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles Kamarudin, Nur Hidayatul Nazirah Abdul Jalil, Aishah Triwahyono, Sugeng Sazegar, Mohammad Reza Hamdan, Salehhuddin Baba, Sayang Ahmad, Arshad QD Chemistry Mesoporous silica nanoparticles (MSN) with 1-10 wt% loading of aluminum (Al) were prepared and characterized by XRD, N-2 physisorption, Si-29 and Al-27 NMR, FT-IR and FT-IR preadsorbed pyridine. All samples were evaluated for ibuprofen adsorption and release. The results showed that MSN gave almost complete ibuprofen adsorption while the addition of 1, 5, and 10 wt% Al onto MSN (1Al-MSN, 5Al-MSN and 10Al-MSN) resulted in 35%, 58%, and 79% of adsorption, respectively. The characterization results elucidated that the highest adsorptivity of MSN was due to its highest surface silanol groups, while the increase in Bronsted acidity upon loading of Al provided more adsorption sites for the higher activity. Regardless of its highest adsorption capacity, MSN demonstrated the highest and fastest release (similar to 100%) in 10 h, followed by 1Al-MSN, 5Al-MSN and 10Al-MSN. The increase in Al loading increased the acid sites that hold the ibuprofen molecules, which raised the retention in ibuprofen release. The pK(a) of Si-OH-Al that is lower than Si-OH sites also attracted the ibuprofen more strongly, which resulted in the slower release of Al-MSN as compared to MSN. The cytotoxicity study exhibited that ibuprofen loaded Al-MSN was able to reduce the toxicity in the WRL-68 cells, verifying its ability to hold and slow the release of ibuprofen as well as minimize the risk of drug overdose. Royal SOC Chemistry 2015 Article PeerReviewed Kamarudin, Nur Hidayatul Nazirah and Abdul Jalil, Aishah and Triwahyono, Sugeng and Sazegar, Mohammad Reza and Hamdan, Salehhuddin and Baba, Sayang and Ahmad, Arshad (2015) Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles. RSC Advances, 5 (38). pp. 30023-30031. ISSN 2046-2069 http://dx.doi.org/10.1039/c4ra16761a DOI:10.1039/c4ra16761a
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Sazegar, Mohammad Reza
Hamdan, Salehhuddin
Baba, Sayang
Ahmad, Arshad
Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
description Mesoporous silica nanoparticles (MSN) with 1-10 wt% loading of aluminum (Al) were prepared and characterized by XRD, N-2 physisorption, Si-29 and Al-27 NMR, FT-IR and FT-IR preadsorbed pyridine. All samples were evaluated for ibuprofen adsorption and release. The results showed that MSN gave almost complete ibuprofen adsorption while the addition of 1, 5, and 10 wt% Al onto MSN (1Al-MSN, 5Al-MSN and 10Al-MSN) resulted in 35%, 58%, and 79% of adsorption, respectively. The characterization results elucidated that the highest adsorptivity of MSN was due to its highest surface silanol groups, while the increase in Bronsted acidity upon loading of Al provided more adsorption sites for the higher activity. Regardless of its highest adsorption capacity, MSN demonstrated the highest and fastest release (similar to 100%) in 10 h, followed by 1Al-MSN, 5Al-MSN and 10Al-MSN. The increase in Al loading increased the acid sites that hold the ibuprofen molecules, which raised the retention in ibuprofen release. The pK(a) of Si-OH-Al that is lower than Si-OH sites also attracted the ibuprofen more strongly, which resulted in the slower release of Al-MSN as compared to MSN. The cytotoxicity study exhibited that ibuprofen loaded Al-MSN was able to reduce the toxicity in the WRL-68 cells, verifying its ability to hold and slow the release of ibuprofen as well as minimize the risk of drug overdose.
format Article
author Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Sazegar, Mohammad Reza
Hamdan, Salehhuddin
Baba, Sayang
Ahmad, Arshad
author_facet Kamarudin, Nur Hidayatul Nazirah
Abdul Jalil, Aishah
Triwahyono, Sugeng
Sazegar, Mohammad Reza
Hamdan, Salehhuddin
Baba, Sayang
Ahmad, Arshad
author_sort Kamarudin, Nur Hidayatul Nazirah
title Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
title_short Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
title_full Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
title_fullStr Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
title_full_unstemmed Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
title_sort elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles
publisher Royal SOC Chemistry
publishDate 2015
url http://eprints.utm.my/id/eprint/54968/
http://dx.doi.org/10.1039/c4ra16761a
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score 13.211869

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