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Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts

Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity. Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography...

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Main Authors: Ayob, Zahidah, Mohd. Bohari, Siti Pauliena, Abd. Samad, Azman, Jamil, Shajarahtunnur
Format: Article
Language:English
Published: Hindawi Limited 2014
Subjects:
QH Natural history
R Medicine (General)
Online Access:http://eprints.utm.my/id/eprint/52280/1/ZahidahAyob2014_CytotoxicActivitiesAgainstBreastCancer.pdf
http://eprints.utm.my/id/eprint/52280/
http://dx.doi.org/10.1155/2014/732980
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spelling my.utm.522802018-09-17T04:01:36Z http://eprints.utm.my/id/eprint/52280/ Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts Ayob, Zahidah Mohd. Bohari, Siti Pauliena Abd. Samad, Azman Jamil, Shajarahtunnur QH Natural history R Medicine (General) Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity. Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID). The results indicated that highest concentrations of kaempferol and naringenin were detected in leaves extracted from Mersing with 1591.80 mg/kg and 444.35 mg/kg, respectively. Positive correlations were observed between kaempferol and naringenin concentrations in all leaf extracts analysed with the Pearson method. The effects of kaempferol and naringenin from leaf extracts were examined on breast cancer cell lines (MDA-MB-231 and MDA-MB-468) using MTT assay. Leaf extract from Mersing showed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 40 g/mL, respectively, compared to other leaf extracts. Kaempferol possessed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 34 g/mL, respectively. These findings suggest that the presence of kaempferol in Mersing leaf extract contributed to high cytotoxicity of both MDA-MB-231 and MDA-MB-468 cancer cell lines Hindawi Limited 2014 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/52280/1/ZahidahAyob2014_CytotoxicActivitiesAgainstBreastCancer.pdf Ayob, Zahidah and Mohd. Bohari, Siti Pauliena and Abd. Samad, Azman and Jamil, Shajarahtunnur (2014) Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts. Evidence-Based Complementary and Alternative Medicine . ISSN 1741-427X http://dx.doi.org/10.1155/2014/732980 DOI: 10.1155/2014/732980
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QH Natural history
R Medicine (General)
spellingShingle QH Natural history
R Medicine (General)
Ayob, Zahidah
Mohd. Bohari, Siti Pauliena
Abd. Samad, Azman
Jamil, Shajarahtunnur
Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
description Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity. Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID). The results indicated that highest concentrations of kaempferol and naringenin were detected in leaves extracted from Mersing with 1591.80 mg/kg and 444.35 mg/kg, respectively. Positive correlations were observed between kaempferol and naringenin concentrations in all leaf extracts analysed with the Pearson method. The effects of kaempferol and naringenin from leaf extracts were examined on breast cancer cell lines (MDA-MB-231 and MDA-MB-468) using MTT assay. Leaf extract from Mersing showed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 40 g/mL, respectively, compared to other leaf extracts. Kaempferol possessed high cytotoxicity against MDA-MB-468 and MDA-MB-231 with ICvalues of 23 g/mL and 34 g/mL, respectively. These findings suggest that the presence of kaempferol in Mersing leaf extract contributed to high cytotoxicity of both MDA-MB-231 and MDA-MB-468 cancer cell lines
format Article
author Ayob, Zahidah
Mohd. Bohari, Siti Pauliena
Abd. Samad, Azman
Jamil, Shajarahtunnur
author_facet Ayob, Zahidah
Mohd. Bohari, Siti Pauliena
Abd. Samad, Azman
Jamil, Shajarahtunnur
author_sort Ayob, Zahidah
title Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
title_short Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
title_full Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
title_fullStr Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
title_full_unstemmed Cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
title_sort cytotoxic activities against breast cancer cells of local justicia gendarussa crude extracts
publisher Hindawi Limited
publishDate 2014
url http://eprints.utm.my/id/eprint/52280/1/ZahidahAyob2014_CytotoxicActivitiesAgainstBreastCancer.pdf
http://eprints.utm.my/id/eprint/52280/
http://dx.doi.org/10.1155/2014/732980
_version_ 1643653177494470656
score 13.211869

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