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The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance

In this study, lactose crystalline powder was produced to improve its stability. The effect of micronised crystalline lactose on a dry powder inhalation formulation was investigated. Supercritical carbon dioxide (scCO 2) modified with menthol was used for the conditioning of spray-dried amorphous la...

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Main Authors: Syed Muhammad, Syed Anuar Faua'ad, Tang, Patricia, Chan, Hak Kim, Dehghania, Fariba
Format: Article
Published: Elsevier B. V 2012
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/47607/
http://dx.doi.org/10.1016/j.supflu.2012.07.013
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spelling my.utm.476072019-03-05T02:54:14Z http://eprints.utm.my/id/eprint/47607/ The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance Syed Muhammad, Syed Anuar Faua'ad Tang, Patricia Chan, Hak Kim Dehghania, Fariba TP Chemical technology In this study, lactose crystalline powder was produced to improve its stability. The effect of micronised crystalline lactose on a dry powder inhalation formulation was investigated. Supercritical carbon dioxide (scCO 2) modified with menthol was used for the conditioning of spray-dried amorphous lactose and salbutamol sulphate to generate micro-spherical crystalline powders. The optimum processing conditions, which include: menthol concentration, temperature and processing time, were determined by experimental design to produce crystalline and a desired particle size. The average particle size of spray-dried amorphous lactose decreased from 8.15 ± 0.28 μm to 7.60 ± 0.10 μm after conditioning with modified CO 2 at 150 bar and 50 °C for a period of 5 h. The SEM results shows that these particles kept their micro-spherical shape, however, the particle surface became rough due to crystallisation. This particle size reduction was most likely due to increasing surface roughness, which decreased agglomeration between particles. The blend of this fine powder and coarse crystalline lactose enhanced salbutamol sulphate inhalation performance. The emitted fine particle fraction of salbutamol sulphate was enhanced to 40 ± 0.3% compare to the samples that contained only coarse lactose (38.2 ± 0.6%) or conditioned lactose (24.6 ± 0.4%). Elsevier B. V 2012 Article PeerReviewed Syed Muhammad, Syed Anuar Faua'ad and Tang, Patricia and Chan, Hak Kim and Dehghania, Fariba (2012) The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. The Journal of Supercritical Fluids, 71 . pp. 92-101. ISSN 0896-8446 http://dx.doi.org/10.1016/j.supflu.2012.07.013 DOI:10.1016/j.supflu.2012.07.013
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Syed Muhammad, Syed Anuar Faua'ad
Tang, Patricia
Chan, Hak Kim
Dehghania, Fariba
The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
description In this study, lactose crystalline powder was produced to improve its stability. The effect of micronised crystalline lactose on a dry powder inhalation formulation was investigated. Supercritical carbon dioxide (scCO 2) modified with menthol was used for the conditioning of spray-dried amorphous lactose and salbutamol sulphate to generate micro-spherical crystalline powders. The optimum processing conditions, which include: menthol concentration, temperature and processing time, were determined by experimental design to produce crystalline and a desired particle size. The average particle size of spray-dried amorphous lactose decreased from 8.15 ± 0.28 μm to 7.60 ± 0.10 μm after conditioning with modified CO 2 at 150 bar and 50 °C for a period of 5 h. The SEM results shows that these particles kept their micro-spherical shape, however, the particle surface became rough due to crystallisation. This particle size reduction was most likely due to increasing surface roughness, which decreased agglomeration between particles. The blend of this fine powder and coarse crystalline lactose enhanced salbutamol sulphate inhalation performance. The emitted fine particle fraction of salbutamol sulphate was enhanced to 40 ± 0.3% compare to the samples that contained only coarse lactose (38.2 ± 0.6%) or conditioned lactose (24.6 ± 0.4%).
format Article
author Syed Muhammad, Syed Anuar Faua'ad
Tang, Patricia
Chan, Hak Kim
Dehghania, Fariba
author_facet Syed Muhammad, Syed Anuar Faua'ad
Tang, Patricia
Chan, Hak Kim
Dehghania, Fariba
author_sort Syed Muhammad, Syed Anuar Faua'ad
title The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
title_short The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
title_full The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
title_fullStr The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
title_full_unstemmed The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
title_sort effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance
publisher Elsevier B. V
publishDate 2012
url http://eprints.utm.my/id/eprint/47607/
http://dx.doi.org/10.1016/j.supflu.2012.07.013
_version_ 1643652348999892992
score 13.211869

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