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Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites

In this article, modified κ-carrageenan hydrogel nanocomposites were synthesized to increase the release ability of carrageenan hydrogels under gastrointestinal conditions. The effect of MgO nanoparticle loading in a model drug (methylene blue) release is investigated. Characterization of hydrogels...

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Main Authors: Hezaveh, Hadi, Muhamad, Ida Idayu
Format: Article
Published: Elsevier Ltd. 2012
Subjects:
QH Natural history
Online Access:http://eprints.utm.my/id/eprint/47077/
http://dx.doi.org/10.1016/j.ijbiomac.2012.03.017
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spelling my.utm.470772019-03-31T08:31:36Z http://eprints.utm.my/id/eprint/47077/ Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites Hezaveh, Hadi Muhamad, Ida Idayu QH Natural history In this article, modified κ-carrageenan hydrogel nanocomposites were synthesized to increase the release ability of carrageenan hydrogels under gastrointestinal conditions. The effect of MgO nanoparticle loading in a model drug (methylene blue) release is investigated. Characterization of hydrogels were carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM) and Differential Scanning Calorimetry (DSC). Genipin was used to increase the delivery performance in gastrointestinal tract delivery by decreasing release in simulated stomach conditions and increasing release in simulated intestine conditions. It is shown that the amount of methylene blue released from genipin-cross-linked nanocomposites can be 67.5% higher in intestine medium and 56% lower in the stomach compared to κ-carrageenan hydrogel. It was found that by changing the nanoparticle loading and genipin concentration in the composite, the amount of drug released can be monitored. Therefore, applying nanoparticles appears to be a potential strategy to develop controlled drug delivery especially in gastrointestinal tract studies. Elsevier Ltd. 2012 Article PeerReviewed Hezaveh, Hadi and Muhamad, Ida Idayu (2012) Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites. International Journal of Biological Macromolecules, 50 . pp. 1334-1340. ISSN 0141-8130 http://dx.doi.org/10.1016/j.ijbiomac.2012.03.017 DOI:10.1016/j.ijbiomac.2012.03.017
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QH Natural history
spellingShingle QH Natural history
Hezaveh, Hadi
Muhamad, Ida Idayu
Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
description In this article, modified κ-carrageenan hydrogel nanocomposites were synthesized to increase the release ability of carrageenan hydrogels under gastrointestinal conditions. The effect of MgO nanoparticle loading in a model drug (methylene blue) release is investigated. Characterization of hydrogels were carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM) and Differential Scanning Calorimetry (DSC). Genipin was used to increase the delivery performance in gastrointestinal tract delivery by decreasing release in simulated stomach conditions and increasing release in simulated intestine conditions. It is shown that the amount of methylene blue released from genipin-cross-linked nanocomposites can be 67.5% higher in intestine medium and 56% lower in the stomach compared to κ-carrageenan hydrogel. It was found that by changing the nanoparticle loading and genipin concentration in the composite, the amount of drug released can be monitored. Therefore, applying nanoparticles appears to be a potential strategy to develop controlled drug delivery especially in gastrointestinal tract studies.
format Article
author Hezaveh, Hadi
Muhamad, Ida Idayu
author_facet Hezaveh, Hadi
Muhamad, Ida Idayu
author_sort Hezaveh, Hadi
title Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
title_short Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
title_full Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
title_fullStr Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
title_full_unstemmed Impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
title_sort impact of metal oxide nanoparticles on oral release properties of ph-sensistive hydrogel nanocomposites
publisher Elsevier Ltd.
publishDate 2012
url http://eprints.utm.my/id/eprint/47077/
http://dx.doi.org/10.1016/j.ijbiomac.2012.03.017
_version_ 1643652227215130624
score 13.211869

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