Conformational transitions of proteins engaged in dna double-strand break repair, analysed by tryptophan fluorescence emission and fret

We analysed protein-DNA and protein-protein interactions relevant to the repair of DNA DSBs (double-strand breaks) by NHEJ (non-homologous end-joining). Conformational transitions in mammalian DNA ligases III (LigIII) and IV (LigIV), as well as in PARP-1 [poly(ADP-ribose) polymerase-1], were analyse...

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Bibliographic Details
Main Authors: Rosidi, Bustanur, Stankova, Katia, Ivanova, Katia, Mladenov, Emil, Sharma, Rosidi, Boteva, Rayna, Iliakis, George, Sharma, Aparna
Format: Article
Published: 2012
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Online Access:http://eprints.utm.my/id/eprint/46730/
http://dx.doi.org/10.1042/BJ20112151
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