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Simulation of direct perfusion through 3d cellular scaffolds with different porosity

The perfusion bioreactor has become an ideal environment for cultivating tissues such as cardiac muscle, liver and cartilage. In this study, a perfusion process was modeled using computational fluid dynamics (CFD). The CFD model is based on simplification of the geometry of porous scaffolds, and is...

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Main Authors: Ochsner, Andreas, Kadir, M. R. A., Harun, Muhamad Noor, Sadir, Sahba
Format: Conference or Workshop Item
Published: 2011
Subjects:
TJ Mechanical engineering and machinery
Online Access:http://eprints.utm.my/id/eprint/46263/
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spelling my.utm.462632017-07-09T13:18:36Z http://eprints.utm.my/id/eprint/46263/ Simulation of direct perfusion through 3d cellular scaffolds with different porosity Ochsner, Andreas Kadir, M. R. A. Harun, Muhamad Noor Sadir, Sahba TJ Mechanical engineering and machinery The perfusion bioreactor has become an ideal environment for cultivating tissues such as cardiac muscle, liver and cartilage. In this study, a perfusion process was modeled using computational fluid dynamics (CFD). The CFD model is based on simplification of the geometry of porous scaffolds, and is designed to predict functions that relate fluid's characteristics, namely wall shear stress level and distribution, pressure drop and permeability, to the porosity of scaffolds. Three group models, corresponding to three different porosities were built. A commercial finite volume code is used to simulate the model. This simulation showed the influence of the geometrical scaffold parameter porosity on the distribution and level of shear stress, pressure drop and mass flow rate. Based on these investigations, the dynamic conditions of a micro fluid passing through the scaffold were characterized for tissue engineering applications. 2011 Conference or Workshop Item PeerReviewed Ochsner, Andreas and Kadir, M. R. A. and Harun, Muhamad Noor and Sadir, Sahba (2011) Simulation of direct perfusion through 3d cellular scaffolds with different porosity. In: 2011 International Conference On Bioscience, Biochemistry And Bioinformatics. http://apps.webofknowledge.com.ezproxy.utm.my/Search.do?product=WOS&SID=U2GNxMzpcYZAlEpveAS&search_mode=GeneralSearch&prID=fc6fe122-91f5-41f4-b159-f6552158a5e9
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Ochsner, Andreas
Kadir, M. R. A.
Harun, Muhamad Noor
Sadir, Sahba
Simulation of direct perfusion through 3d cellular scaffolds with different porosity
description The perfusion bioreactor has become an ideal environment for cultivating tissues such as cardiac muscle, liver and cartilage. In this study, a perfusion process was modeled using computational fluid dynamics (CFD). The CFD model is based on simplification of the geometry of porous scaffolds, and is designed to predict functions that relate fluid's characteristics, namely wall shear stress level and distribution, pressure drop and permeability, to the porosity of scaffolds. Three group models, corresponding to three different porosities were built. A commercial finite volume code is used to simulate the model. This simulation showed the influence of the geometrical scaffold parameter porosity on the distribution and level of shear stress, pressure drop and mass flow rate. Based on these investigations, the dynamic conditions of a micro fluid passing through the scaffold were characterized for tissue engineering applications.
format Conference or Workshop Item
author Ochsner, Andreas
Kadir, M. R. A.
Harun, Muhamad Noor
Sadir, Sahba
author_facet Ochsner, Andreas
Kadir, M. R. A.
Harun, Muhamad Noor
Sadir, Sahba
author_sort Ochsner, Andreas
title Simulation of direct perfusion through 3d cellular scaffolds with different porosity
title_short Simulation of direct perfusion through 3d cellular scaffolds with different porosity
title_full Simulation of direct perfusion through 3d cellular scaffolds with different porosity
title_fullStr Simulation of direct perfusion through 3d cellular scaffolds with different porosity
title_full_unstemmed Simulation of direct perfusion through 3d cellular scaffolds with different porosity
title_sort simulation of direct perfusion through 3d cellular scaffolds with different porosity
publishDate 2011
url http://eprints.utm.my/id/eprint/46263/
http://apps.webofknowledge.com.ezproxy.utm.my/Search.do?product=WOS&SID=U2GNxMzpcYZAlEpveAS&search_mode=GeneralSearch&prID=fc6fe122-91f5-41f4-b159-f6552158a5e9
_version_ 1643651983728443392
score 13.211869

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