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The effects of zeolite X and Y on cancer cell lines

Zeolites are hydrated silicates of aluminium that have been very useful in many industry because of its microporous property, absorbance ability and ion exchange capacity. It is currently viewed as a potential adjuvant in cancer therapy due to its ability to inhibit the proliferation of cancer cells...

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Main Authors:	Nik Malek, Nik Ahmad Nizam, Ghazi, Noor Azhana, Amir Hussain, Khairina ‘Izzati
Format:	Article
Published:	Penerbit UTHM 2012
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/33588/ http://penerbit.uthm.edu.my/ojs/index.php/JST/article/view/465
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id	my.utm.33588
record_format	eprints
spelling	my.utm.335882019-01-28T03:50:24Z http://eprints.utm.my/id/eprint/33588/ The effects of zeolite X and Y on cancer cell lines Nik Malek, Nik Ahmad Nizam Ghazi, Noor Azhana Amir Hussain, Khairina ‘Izzati QD Chemistry Zeolites are hydrated silicates of aluminium that have been very useful in many industry because of its microporous property, absorbance ability and ion exchange capacity. It is currently viewed as a potential adjuvant in cancer therapy due to its ability to inhibit the proliferation of cancer cells. Research on natural zeolite clinoptilolite application as anticancer agent has been proven by others. However, the effect of other types of zeolite on cancer cells is still uncertain. This study is performed to determine the effects of zeolite X and Y on cancer cell lines proliferation in vitro. Cancer cell lines HeLa, AsPC-1 and 911 cells were cultured in designated medium treated with zeolite X and zeolite Y at the concentration of 5 mg/ml and 50 mg/ml. Fetal Bovine Serum (FBS) concentrations were modified to 5%, 10%, 15% and 20%. After 72 hours incubation, the efficacy of zeolite to treat cancer cell lines were measured by means of cell viability test via MTT assay. Overall results showed that cancer cell lines cultivated in the medium treated with 50 mg/ml of zeolite X and 5% FBS exhibited the highest inhibition of cell proliferation and decrease in cell viability. This finding provides preliminary information in the study of determining the potential use of zeolite as anticancer agent for alternative or complementary therapy. Penerbit UTHM 2012 Article PeerReviewed Nik Malek, Nik Ahmad Nizam and Ghazi, Noor Azhana and Amir Hussain, Khairina ‘Izzati (2012) The effects of zeolite X and Y on cancer cell lines. Journal of Science and Technology, 4 (1). pp. 33-40. ISSN 2229-8460 http://penerbit.uthm.edu.my/ojs/index.php/JST/article/view/465
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Nik Malek, Nik Ahmad Nizam Ghazi, Noor Azhana Amir Hussain, Khairina ‘Izzati The effects of zeolite X and Y on cancer cell lines
description	Zeolites are hydrated silicates of aluminium that have been very useful in many industry because of its microporous property, absorbance ability and ion exchange capacity. It is currently viewed as a potential adjuvant in cancer therapy due to its ability to inhibit the proliferation of cancer cells. Research on natural zeolite clinoptilolite application as anticancer agent has been proven by others. However, the effect of other types of zeolite on cancer cells is still uncertain. This study is performed to determine the effects of zeolite X and Y on cancer cell lines proliferation in vitro. Cancer cell lines HeLa, AsPC-1 and 911 cells were cultured in designated medium treated with zeolite X and zeolite Y at the concentration of 5 mg/ml and 50 mg/ml. Fetal Bovine Serum (FBS) concentrations were modified to 5%, 10%, 15% and 20%. After 72 hours incubation, the efficacy of zeolite to treat cancer cell lines were measured by means of cell viability test via MTT assay. Overall results showed that cancer cell lines cultivated in the medium treated with 50 mg/ml of zeolite X and 5% FBS exhibited the highest inhibition of cell proliferation and decrease in cell viability. This finding provides preliminary information in the study of determining the potential use of zeolite as anticancer agent for alternative or complementary therapy.
format	Article
author	Nik Malek, Nik Ahmad Nizam Ghazi, Noor Azhana Amir Hussain, Khairina ‘Izzati
author_facet	Nik Malek, Nik Ahmad Nizam Ghazi, Noor Azhana Amir Hussain, Khairina ‘Izzati
author_sort	Nik Malek, Nik Ahmad Nizam
title	The effects of zeolite X and Y on cancer cell lines
title_short	The effects of zeolite X and Y on cancer cell lines
title_full	The effects of zeolite X and Y on cancer cell lines
title_fullStr	The effects of zeolite X and Y on cancer cell lines
title_full_unstemmed	The effects of zeolite X and Y on cancer cell lines
title_sort	effects of zeolite x and y on cancer cell lines
publisher	Penerbit UTHM
publishDate	2012
url	http://eprints.utm.my/id/eprint/33588/ http://penerbit.uthm.edu.my/ojs/index.php/JST/article/view/465
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score	13.211869

The effects of zeolite X and Y on cancer cell lines

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