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The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells

Labisia pumila (Myrsinaceae) or commonly known as 'Kacip Fatimah' is traditionally used by Malaysian women to address reproductive health. In this study, we investigated the effects of standardized water extract and methanolic extract of Labisia pumila on the collagen synthesis in UVB-irra...

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Main Authors: Abd. Majid, Fadzilah @ Adibah, Mukrish, M. H., Chua, L. S., Ya'akob, Harisun, Sarmidi, Mohamad Roji
Format: Article
Published: Tissue Engineering and Regenerative Medicine Society of Malaysia 2012
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/33586/
http://regres.tesma.org.my/pdf/RR-120312-009-R1%20final%20format%20%285%29.pdf
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spelling my.utm.335862019-01-29T06:01:48Z http://eprints.utm.my/id/eprint/33586/ The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells Abd. Majid, Fadzilah @ Adibah Mukrish, M. H. Chua, L. S. Ya'akob, Harisun Sarmidi, Mohamad Roji QD Chemistry Labisia pumila (Myrsinaceae) or commonly known as 'Kacip Fatimah' is traditionally used by Malaysian women to address reproductive health. In this study, we investigated the effects of standardized water extract and methanolic extract of Labisia pumila on the collagen synthesis in UVB-irradiated and nonirradiated Human Skin Fibroblast cells (HSFl184). Both plant extracts caused significant increase in the collagen production of the HSFl184 cells in both UVB and non UVB irradiated HSFl184 cells. At concentration of 1 x 10-5 ug/ml, the standardized water extract of Labisia pumila promoted an increase of up to 70% in the collagen synthesis in for the HSFl184 UVB irradiated cells whereas in the methanolic extract at similar concentration the increase was only 20%. This concentration is shown to be the optimum concentration for both extracts of Labisia pumila throughout the course of the study. Beyond this concentration, the methanolic extracts indicated dose dependent inhibition effect.The result clearly indicates that the standardized water extract of Labisia pumila provides better effect than the methanolic extract. Tissue Engineering and Regenerative Medicine Society of Malaysia 2012 Article PeerReviewed Abd. Majid, Fadzilah @ Adibah and Mukrish, M. H. and Chua, L. S. and Ya'akob, Harisun and Sarmidi, Mohamad Roji (2012) The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells. Regenerative Research, 1 (1). pp. 33-37. ISSN 2232-0822 http://regres.tesma.org.my/pdf/RR-120312-009-R1%20final%20format%20%285%29.pdf
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Abd. Majid, Fadzilah @ Adibah
Mukrish, M. H.
Chua, L. S.
Ya'akob, Harisun
Sarmidi, Mohamad Roji
The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
description Labisia pumila (Myrsinaceae) or commonly known as 'Kacip Fatimah' is traditionally used by Malaysian women to address reproductive health. In this study, we investigated the effects of standardized water extract and methanolic extract of Labisia pumila on the collagen synthesis in UVB-irradiated and nonirradiated Human Skin Fibroblast cells (HSFl184). Both plant extracts caused significant increase in the collagen production of the HSFl184 cells in both UVB and non UVB irradiated HSFl184 cells. At concentration of 1 x 10-5 ug/ml, the standardized water extract of Labisia pumila promoted an increase of up to 70% in the collagen synthesis in for the HSFl184 UVB irradiated cells whereas in the methanolic extract at similar concentration the increase was only 20%. This concentration is shown to be the optimum concentration for both extracts of Labisia pumila throughout the course of the study. Beyond this concentration, the methanolic extracts indicated dose dependent inhibition effect.The result clearly indicates that the standardized water extract of Labisia pumila provides better effect than the methanolic extract.
format Article
author Abd. Majid, Fadzilah @ Adibah
Mukrish, M. H.
Chua, L. S.
Ya'akob, Harisun
Sarmidi, Mohamad Roji
author_facet Abd. Majid, Fadzilah @ Adibah
Mukrish, M. H.
Chua, L. S.
Ya'akob, Harisun
Sarmidi, Mohamad Roji
author_sort Abd. Majid, Fadzilah @ Adibah
title The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
title_short The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
title_full The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
title_fullStr The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
title_full_unstemmed The effects of water and methanolic extracts of Labisia pumila on collagen synthesis in human skin fibroblast (HSF1184) Cells
title_sort effects of water and methanolic extracts of labisia pumila on collagen synthesis in human skin fibroblast (hsf1184) cells
publisher Tissue Engineering and Regenerative Medicine Society of Malaysia
publishDate 2012
url http://eprints.utm.my/id/eprint/33586/
http://regres.tesma.org.my/pdf/RR-120312-009-R1%20final%20format%20%285%29.pdf
_version_ 1643649373319462912
score 13.211869

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