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New phytochemical based cocktail for in vitro adipocytes differentiation

Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The c...

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Main Authors:	Abdul Majid, Fadzilah Adibah, M., Taher, Sarmidi, Mohd. Roji
Format:	Conference or Workshop Item
Language:	English
Published:	2005
Subjects:	SF Animal culture RM Therapeutics. Pharmacology
Online Access:	http://eprints.utm.my/id/eprint/3145/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf http://eprints.utm.my/id/eprint/3145/
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id	my.utm.3145
record_format	eprints
spelling	my.utm.31452017-08-28T07:51:39Z http://eprints.utm.my/id/eprint/3145/ New phytochemical based cocktail for in vitro adipocytes differentiation Abdul Majid, Fadzilah Adibah M., Taher Sarmidi, Mohd. Roji SF Animal culture RM Therapeutics. Pharmacology Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The cocktail of these components is expensive. Furthermore, dexamethasone has been recently categorized as a restricted item in Malaysia. Therefore, in this work, an alternative component to replace these compounds is necessary. The first scope of the study is to replace insulin with suitable phytochemical based compound using Malaysian rich biodiversity. Based on the lead compound screening of phytochemicals for diabetes, cinnamon water extract has shown to have the ability to increase glucose uptake in adipocytes culture tested. The active component in the extract has been identified as Cinnamtannin B1 and the results indicates that this compound react similar to insulin in promoting preadipocytes differentiation to adipocytes tissue. First scope of the project has been achieved where Cinnamtannin B1 is found to be a potential candidate to replace insulin in currently used adipocytes differentiation cocktail. This finding is hoped to offer the possibility of using a non biological alternative to insulin in adipocytes differentiation. 2005 Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/3145/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf Abdul Majid, Fadzilah Adibah and M., Taher and Sarmidi, Mohd. Roji (2005) New phytochemical based cocktail for in vitro adipocytes differentiation. In: New Phytochemical Based Cocktail For In Vitro Adipocytes Differentiation. (Unpublished)
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	SF Animal culture RM Therapeutics. Pharmacology
spellingShingle	SF Animal culture RM Therapeutics. Pharmacology Abdul Majid, Fadzilah Adibah M., Taher Sarmidi, Mohd. Roji New phytochemical based cocktail for in vitro adipocytes differentiation
description	Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The cocktail of these components is expensive. Furthermore, dexamethasone has been recently categorized as a restricted item in Malaysia. Therefore, in this work, an alternative component to replace these compounds is necessary. The first scope of the study is to replace insulin with suitable phytochemical based compound using Malaysian rich biodiversity. Based on the lead compound screening of phytochemicals for diabetes, cinnamon water extract has shown to have the ability to increase glucose uptake in adipocytes culture tested. The active component in the extract has been identified as Cinnamtannin B1 and the results indicates that this compound react similar to insulin in promoting preadipocytes differentiation to adipocytes tissue. First scope of the project has been achieved where Cinnamtannin B1 is found to be a potential candidate to replace insulin in currently used adipocytes differentiation cocktail. This finding is hoped to offer the possibility of using a non biological alternative to insulin in adipocytes differentiation.
format	Conference or Workshop Item
author	Abdul Majid, Fadzilah Adibah M., Taher Sarmidi, Mohd. Roji
author_facet	Abdul Majid, Fadzilah Adibah M., Taher Sarmidi, Mohd. Roji
author_sort	Abdul Majid, Fadzilah Adibah
title	New phytochemical based cocktail for in vitro adipocytes differentiation
title_short	New phytochemical based cocktail for in vitro adipocytes differentiation
title_full	New phytochemical based cocktail for in vitro adipocytes differentiation
title_fullStr	New phytochemical based cocktail for in vitro adipocytes differentiation
title_full_unstemmed	New phytochemical based cocktail for in vitro adipocytes differentiation
title_sort	new phytochemical based cocktail for in vitro adipocytes differentiation
publishDate	2005
url	http://eprints.utm.my/id/eprint/3145/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf http://eprints.utm.my/id/eprint/3145/
_version_	1643643745671839744
score	13.211869

New phytochemical based cocktail for in vitro adipocytes differentiation

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