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New phytochemical based cocktail for in vitro adipocytes differentiation

Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The c...

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Main Authors: Abdul Majid, Fadzilah Adibah, M., Taher, Sarmidi, Mohd. Roji
Format: Monograph
Language:English
Published: Unknown 2005
Subjects:
SF Animal culture
Online Access:http://eprints.utm.my/id/eprint/3143/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf
http://eprints.utm.my/id/eprint/3143/
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spelling my.utm.31432017-08-03T04:25:49Z http://eprints.utm.my/id/eprint/3143/ New phytochemical based cocktail for in vitro adipocytes differentiation Abdul Majid, Fadzilah Adibah M., Taher Sarmidi, Mohd. Roji SF Animal culture Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The cocktail of these components is expensive. Furthermore, dexamethasone has been recently categorized as a restricted item in Malaysia. Therefore, in this work, an alternative component to replace these compounds is necessary. The first scope of the study is to replace insulin with suitable phytochemical based compound using Malaysian rich biodiversity. Based on the lead compound screening of phytochemicals for diabetes, cinnamon water extract has shown to have the ability to increase glucose uptake in adipocytes culture tested. The active component in the extract has been identified as Cinnamtannin B1 and the results indicates that this compound react similar to insulin in promoting preadipocytes differentiation to adipocytes tissue. First scope of the project has been achieved where Cinnamtannin B1 is found to be a potential candidate to replace insulin in currently used adipocytes differentiation cocktail. This finding is hoped to offer the possibility of using a non biological alternative to insulin in adipocytes differentiation. Unknown 2005 Monograph NonPeerReviewed application/pdf en http://eprints.utm.my/id/eprint/3143/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf Abdul Majid, Fadzilah Adibah and M., Taher and Sarmidi, Mohd. Roji (2005) New phytochemical based cocktail for in vitro adipocytes differentiation. Project Report. Unknown. (Unpublished)
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic SF Animal culture
spellingShingle SF Animal culture
Abdul Majid, Fadzilah Adibah
M., Taher
Sarmidi, Mohd. Roji
New phytochemical based cocktail for in vitro adipocytes differentiation
description Adipocyte (fat tissue) is commonly used in in vitro study of diabetes and many other areas in endocrinology. Prior to testing, preadipocytes (fat cells) culture will be differentiated to adipocytes using a mixture of three compounds, which are insulin, dexamethasone and isobutylmethylxanthine. The cocktail of these components is expensive. Furthermore, dexamethasone has been recently categorized as a restricted item in Malaysia. Therefore, in this work, an alternative component to replace these compounds is necessary. The first scope of the study is to replace insulin with suitable phytochemical based compound using Malaysian rich biodiversity. Based on the lead compound screening of phytochemicals for diabetes, cinnamon water extract has shown to have the ability to increase glucose uptake in adipocytes culture tested. The active component in the extract has been identified as Cinnamtannin B1 and the results indicates that this compound react similar to insulin in promoting preadipocytes differentiation to adipocytes tissue. First scope of the project has been achieved where Cinnamtannin B1 is found to be a potential candidate to replace insulin in currently used adipocytes differentiation cocktail. This finding is hoped to offer the possibility of using a non biological alternative to insulin in adipocytes differentiation.
format Monograph
author Abdul Majid, Fadzilah Adibah
M., Taher
Sarmidi, Mohd. Roji
author_facet Abdul Majid, Fadzilah Adibah
M., Taher
Sarmidi, Mohd. Roji
author_sort Abdul Majid, Fadzilah Adibah
title New phytochemical based cocktail for in vitro adipocytes differentiation
title_short New phytochemical based cocktail for in vitro adipocytes differentiation
title_full New phytochemical based cocktail for in vitro adipocytes differentiation
title_fullStr New phytochemical based cocktail for in vitro adipocytes differentiation
title_full_unstemmed New phytochemical based cocktail for in vitro adipocytes differentiation
title_sort new phytochemical based cocktail for in vitro adipocytes differentiation
publisher Unknown
publishDate 2005
url http://eprints.utm.my/id/eprint/3143/1/New_Phytochemical_Based_Cocktail-full_Paper.pdf
http://eprints.utm.my/id/eprint/3143/
_version_ 1643643745380335616
score 13.211869

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