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Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy

Sildenafil Citrate (SC) an active ingredient in Viagra and has become one of the most commonly prescribed pharmaceuticals drugs to cure sexual deficiency. Sildenafil is prohibited but still being sold ‘over the counter’ it prescribed SC is readily available in the ‘black market’ in the formed either...

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Main Authors: Yacob, Abdul Rahim, Zinalibdin, Mohamad Raizul, Onn, Zareen Sofia
Format: Article
Published: Diva Enterprises Pvt. Ltd. 2011
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/29006/
http://www.indianjournals.com/ijor.aspx?target=ijor:ijfmt&volume=5&issue=2&article=042
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spelling my.utm.290062019-03-05T01:38:05Z http://eprints.utm.my/id/eprint/29006/ Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy Yacob, Abdul Rahim Zinalibdin, Mohamad Raizul Onn, Zareen Sofia Q Science (General) Sildenafil Citrate (SC) an active ingredient in Viagra and has become one of the most commonly prescribed pharmaceuticals drugs to cure sexual deficiency. Sildenafil is prohibited but still being sold ‘over the counter’ it prescribed SC is readily available in the ‘black market’ in the formed either doped or as pills to help potency. Most chromatographic study by researches have proven to be a powerful method to detect SC. On the other hand, spectroscopic method that will quantify quantitatively the amount of the SC in its formulation is yet to be explored. In Malaysia it has been reported that SC had been doped to coffee powder to enhance sexual activity to drinkers. In this study, five samples from different manufacturers of coffee powder which claims that their coffee have an extra power that can sexually arouse drinkers were collected from Johor Bahru, Malaysia. These coffee powders were then analyzed for SC using colored method Ultra Violet (UV) Spectroscopy at 424 nm. In this reaction, BCG is used and an intense yellow coloration is formed. This is then, used as an indicator to estimate the amount of sildenafil present. This study illustrated a good result with calibration curve linear up to 0.9983. The percentage of accuracy, error and coefficient variance recorded for sildenafil are 0.12%, 0.2% and 3.01% respectively. From the UV analysis, Sample 5 was identified to be positive and contain 18.81±0.55 µg/ml of SC. The other samples either show the absent of SC contain analogue of SC or maybe the level of detectible of SC in coffee powder was too low. Diva Enterprises Pvt. Ltd. 2011-07 Article PeerReviewed Yacob, Abdul Rahim and Zinalibdin, Mohamad Raizul and Onn, Zareen Sofia (2011) Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy. Indian Journal of Forensic Medicine and Toxicology, 5 (2). pp. 123-126. ISSN 0973-9122 http://www.indianjournals.com/ijor.aspx?target=ijor:ijfmt&volume=5&issue=2&article=042
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Yacob, Abdul Rahim
Zinalibdin, Mohamad Raizul
Onn, Zareen Sofia
Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
description Sildenafil Citrate (SC) an active ingredient in Viagra and has become one of the most commonly prescribed pharmaceuticals drugs to cure sexual deficiency. Sildenafil is prohibited but still being sold ‘over the counter’ it prescribed SC is readily available in the ‘black market’ in the formed either doped or as pills to help potency. Most chromatographic study by researches have proven to be a powerful method to detect SC. On the other hand, spectroscopic method that will quantify quantitatively the amount of the SC in its formulation is yet to be explored. In Malaysia it has been reported that SC had been doped to coffee powder to enhance sexual activity to drinkers. In this study, five samples from different manufacturers of coffee powder which claims that their coffee have an extra power that can sexually arouse drinkers were collected from Johor Bahru, Malaysia. These coffee powders were then analyzed for SC using colored method Ultra Violet (UV) Spectroscopy at 424 nm. In this reaction, BCG is used and an intense yellow coloration is formed. This is then, used as an indicator to estimate the amount of sildenafil present. This study illustrated a good result with calibration curve linear up to 0.9983. The percentage of accuracy, error and coefficient variance recorded for sildenafil are 0.12%, 0.2% and 3.01% respectively. From the UV analysis, Sample 5 was identified to be positive and contain 18.81±0.55 µg/ml of SC. The other samples either show the absent of SC contain analogue of SC or maybe the level of detectible of SC in coffee powder was too low.
format Article
author Yacob, Abdul Rahim
Zinalibdin, Mohamad Raizul
Onn, Zareen Sofia
author_facet Yacob, Abdul Rahim
Zinalibdin, Mohamad Raizul
Onn, Zareen Sofia
author_sort Yacob, Abdul Rahim
title Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
title_short Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
title_full Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
title_fullStr Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
title_full_unstemmed Sildenafil detection in coffee powder using bromocresol green (BCG) as indicator by visible and ultra-violet spectroscopy
title_sort sildenafil detection in coffee powder using bromocresol green (bcg) as indicator by visible and ultra-violet spectroscopy
publisher Diva Enterprises Pvt. Ltd.
publishDate 2011
url http://eprints.utm.my/id/eprint/29006/
http://www.indianjournals.com/ijor.aspx?target=ijor:ijfmt&volume=5&issue=2&article=042
_version_ 1643648212401127424
score 13.211869

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