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Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient

The Scale-Up Studies Based On The Constant Oxygen Transfer Coefficient, Kla From 16 L To 150 L Of Aerated And Agitated Bioreactor Were Performed. By Employing The Static Gassing Out Techniques, The Kla Values Were Calculated At Different Sets Of Impeller Speeds And Air Flow Rates Performed In Variou...

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Main Authors: Zainal Alam, Muhd. Nazrul Hisham, Razali, Firdausi
Format: Article
Language:English
Published: Penerbit UTM Press 2005
Subjects:
Q Science (General)
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/1698/1/JTDIS43F7.pdf
http://eprints.utm.my/id/eprint/1698/
http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/789
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spelling my.utm.16982017-11-01T04:17:33Z http://eprints.utm.my/id/eprint/1698/ Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient Zainal Alam, Muhd. Nazrul Hisham Razali, Firdausi Q Science (General) T Technology (General) The Scale-Up Studies Based On The Constant Oxygen Transfer Coefficient, Kla From 16 L To 150 L Of Aerated And Agitated Bioreactor Were Performed. By Employing The Static Gassing Out Techniques, The Kla Values Were Calculated At Different Sets Of Impeller Speeds And Air Flow Rates Performed In Various Viscosities And Temperatures In The 16 L And 150 L Bioengineeringtm Stirred Bioreactor. Empirical Correlation Was Employed To Correlate And Investigate The Dependence Of Kla On Specific Power Input And Superficial Air Velocity. In Maintaining A Constant Kla Upon Scale-Up From 16 L To 150 L, The Specific Power Input And The Superficial Air Velocity Cannot Be Maintained, Thus An Adjustment Has To Be Done. From The Experimental Results At 150 L, It Was Discovered That The Specific Power Input From 0.0001 To 4.2 Kw/M3 And Superficial Air Velocity Within The Range Of 9 × 10-4 M/S To 7 × 10-3 M/S Employed Gave A Comparable Kla Values Achieved At 16 L Scale. Hence, The Calculated Scaling-Up Factor For Impeller Speed And Air Flow Rate Were 0.28 And 3.1, Respectively. The Comparable Results Obtained From Both Scales Confirmed That The Scale-Up Protocol Developed Works. Penerbit UTM Press 2005-12 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/1698/1/JTDIS43F7.pdf Zainal Alam, Muhd. Nazrul Hisham and Razali, Firdausi (2005) Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient. Jurnal Teknologi F (43F). pp. 95-110. ISSN 0127-9696 http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/789
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic Q Science (General)
T Technology (General)
spellingShingle Q Science (General)
T Technology (General)
Zainal Alam, Muhd. Nazrul Hisham
Razali, Firdausi
Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
description The Scale-Up Studies Based On The Constant Oxygen Transfer Coefficient, Kla From 16 L To 150 L Of Aerated And Agitated Bioreactor Were Performed. By Employing The Static Gassing Out Techniques, The Kla Values Were Calculated At Different Sets Of Impeller Speeds And Air Flow Rates Performed In Various Viscosities And Temperatures In The 16 L And 150 L Bioengineeringtm Stirred Bioreactor. Empirical Correlation Was Employed To Correlate And Investigate The Dependence Of Kla On Specific Power Input And Superficial Air Velocity. In Maintaining A Constant Kla Upon Scale-Up From 16 L To 150 L, The Specific Power Input And The Superficial Air Velocity Cannot Be Maintained, Thus An Adjustment Has To Be Done. From The Experimental Results At 150 L, It Was Discovered That The Specific Power Input From 0.0001 To 4.2 Kw/M3 And Superficial Air Velocity Within The Range Of 9 × 10-4 M/S To 7 × 10-3 M/S Employed Gave A Comparable Kla Values Achieved At 16 L Scale. Hence, The Calculated Scaling-Up Factor For Impeller Speed And Air Flow Rate Were 0.28 And 3.1, Respectively. The Comparable Results Obtained From Both Scales Confirmed That The Scale-Up Protocol Developed Works.
format Article
author Zainal Alam, Muhd. Nazrul Hisham
Razali, Firdausi
author_facet Zainal Alam, Muhd. Nazrul Hisham
Razali, Firdausi
author_sort Zainal Alam, Muhd. Nazrul Hisham
title Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
title_short Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
title_full Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
title_fullStr Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
title_full_unstemmed Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient
title_sort scale-up of stirred and aerated bioengineeringtm bioreactor based on constant mass transfer coefficient
publisher Penerbit UTM Press
publishDate 2005
url http://eprints.utm.my/id/eprint/1698/1/JTDIS43F7.pdf
http://eprints.utm.my/id/eprint/1698/
http://www.jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/789
_version_ 1643643394762735616
score 13.211869

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