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Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems

Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent sys...

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Main Authors: Chen, Yong, Mat, Hanapi, Xu, Zhinan, Jin, Zhihua, Cen, Peilin
Format: Article
Published: Chemical Industry Press 2004
Subjects:
QD Chemistry
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/15926/
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spelling my.utm.159262017-10-23T13:07:59Z http://eprints.utm.my/id/eprint/15926/ Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems Chen, Yong Mat, Hanapi Xu, Zhinan Jin, Zhihua Cen, Peilin QD Chemistry TP Chemical technology Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol·L-1 TOMAC +1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process. Chemical Industry Press 2004-08 Article PeerReviewed Chen, Yong and Mat, Hanapi and Xu, Zhinan and Jin, Zhihua and Cen, Peilin (2004) Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems. Chinese Journal of Chemical Engineering, 12 (4). pp. 493-497. ISSN 1004-9541
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
TP Chemical technology
spellingShingle QD Chemistry
TP Chemical technology
Chen, Yong
Mat, Hanapi
Xu, Zhinan
Jin, Zhihua
Cen, Peilin
Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
description Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol·L-1 TOMAC +1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.
format Article
author Chen, Yong
Mat, Hanapi
Xu, Zhinan
Jin, Zhihua
Cen, Peilin
author_facet Chen, Yong
Mat, Hanapi
Xu, Zhinan
Jin, Zhihua
Cen, Peilin
author_sort Chen, Yong
title Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
title_short Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
title_full Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
title_fullStr Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
title_full_unstemmed Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems
title_sort determination of teicoplanin a2's partition coefficient in different liquid-liquid extraction systems
publisher Chemical Industry Press
publishDate 2004
url http://eprints.utm.my/id/eprint/15926/
_version_ 1643646496706396160
score 13.211869

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