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Liquid-liquid separation of antibiotic with reverse micelles

Antibiotics are normally produced in aqueous environments, which require further separation and purification steps. The steps are very important and consume a huge part of the overall production cost. Moreover, the production of antibiotics, which typically involves fermentation process, is usu...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Mohd. Setapar, Siti Hamidah
التنسيق: Book Section
منشور في: Penerbit UTM 2007
الموضوعات:
QD Chemistry
الوصول للمادة أونلاين:http://eprints.utm.my/id/eprint/13556/
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id my.utm.13556
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spelling my.utm.135562011-08-10T01:21:47Z http://eprints.utm.my/id/eprint/13556/ Liquid-liquid separation of antibiotic with reverse micelles Mohd. Setapar, Siti Hamidah QD Chemistry Antibiotics are normally produced in aqueous environments, which require further separation and purification steps. The steps are very important and consume a huge part of the overall production cost. Moreover, the production of antibiotics, which typically involves fermentation process, is usually capital intensive because large and complex fermentors and extensive equipment for multi-step downstream processing are required to handle large volume fermentation broths with a low product concentration (Lee et al., 2004). Thus, improvement of the separation and purification methods can make significant savings to the overall manufacturing costs. A range of separation methods such as conventional solvent extraction, ion-exchange, chromatography, crystallization, or a combination of these methods have been used for the recovery of antibiotics. In the separation of penicillin G from fermentation broth, a solvent extraction method has been used by industry for many years. If the antibiotic is a weak acid with a low pKa value, the pH used in the extraction should be lower than the pKa value to obtain the antibiotic in its free acid form (Gu, 2000). Nabais and Cardoso noted that the biggest concern in current solvent separation technique is the frequent formation of stable emulsions. These emulsions are difficult to be discarded with conventional techniques such as gravitation or centrifugation. These problems lead to other problems such as contamination of the final product, low extraction yield, high solvent losses and clogging of the equipment. Penerbit UTM 2007 Book Section PeerReviewed Mohd. Setapar, Siti Hamidah (2007) Liquid-liquid separation of antibiotic with reverse micelles. In: Advances in Separation Processes. Penerbit UTM, Johor, pp. 154-171. ISBN 978-983-52-05958-8
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Mohd. Setapar, Siti Hamidah
Liquid-liquid separation of antibiotic with reverse micelles
description Antibiotics are normally produced in aqueous environments, which require further separation and purification steps. The steps are very important and consume a huge part of the overall production cost. Moreover, the production of antibiotics, which typically involves fermentation process, is usually capital intensive because large and complex fermentors and extensive equipment for multi-step downstream processing are required to handle large volume fermentation broths with a low product concentration (Lee et al., 2004). Thus, improvement of the separation and purification methods can make significant savings to the overall manufacturing costs. A range of separation methods such as conventional solvent extraction, ion-exchange, chromatography, crystallization, or a combination of these methods have been used for the recovery of antibiotics. In the separation of penicillin G from fermentation broth, a solvent extraction method has been used by industry for many years. If the antibiotic is a weak acid with a low pKa value, the pH used in the extraction should be lower than the pKa value to obtain the antibiotic in its free acid form (Gu, 2000). Nabais and Cardoso noted that the biggest concern in current solvent separation technique is the frequent formation of stable emulsions. These emulsions are difficult to be discarded with conventional techniques such as gravitation or centrifugation. These problems lead to other problems such as contamination of the final product, low extraction yield, high solvent losses and clogging of the equipment.
format Book Section
author Mohd. Setapar, Siti Hamidah
author_facet Mohd. Setapar, Siti Hamidah
author_sort Mohd. Setapar, Siti Hamidah
title Liquid-liquid separation of antibiotic with reverse micelles
title_short Liquid-liquid separation of antibiotic with reverse micelles
title_full Liquid-liquid separation of antibiotic with reverse micelles
title_fullStr Liquid-liquid separation of antibiotic with reverse micelles
title_full_unstemmed Liquid-liquid separation of antibiotic with reverse micelles
title_sort liquid-liquid separation of antibiotic with reverse micelles
publisher Penerbit UTM
publishDate 2007
url http://eprints.utm.my/id/eprint/13556/
_version_ 1643646216981970944
score 13.251813

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