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Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application

In recent years, essential oil has been the subject matter of many investigations due to its eco-friendly and bio-degradable nature. Geranium oil is one of the various essential oils that are used as mosquito repellent. However, stability is one of the issues related to essential oil fonnulations. I...

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Main Authors: Asnawi, S., Abd. Aziz, A., Abd. Aziz, R., Khamis, A. K.
Format: Article
Language:English
Published: Faculty of Chemical and Natural Resource Engineering, UTM 2008
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TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/12241/1/SAsnawi_FormulationofGeraniumOilLoadedSolidLipid2008.pdf
http://eprints.utm.my/id/eprint/12241/
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spelling my.utm.122412011-04-18T02:05:41Z http://eprints.utm.my/id/eprint/12241/ Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application Asnawi, S. Abd. Aziz, A. Abd. Aziz, R. Khamis, A. K. TP Chemical technology In recent years, essential oil has been the subject matter of many investigations due to its eco-friendly and bio-degradable nature. Geranium oil is one of the various essential oils that are used as mosquito repellent. However, stability is one of the issues related to essential oil fonnulations. Incorporation of essential oil in a control-release formulation could solve the problem and it also offers several advantages. In this work, a new delivery system for mosquito repellent based on the incorporation of geranium oil into solid lipid nanoparticles (SLNs) has been studied. The following has been employed for the production of geranium oil loaded solid lipid nanoparticles (GO-SLNs): 5-15% (w/w) stearic acid as the lipid, 0.5-3% (w/w) soy lecithin as the emulsifier, 0.5-3% (w/w) Tween 80 as the co-emulsifier, 5-20% (w/w) dichloromethane also as the co-emulsifier and 8% (w/w) geranium oil as the active ingredient. GO-SLNs were prepared using ultrasonicsolvent emulsification technique. GO-SLNS were characterized using transmission electron microscopy (TEM), photon cross correlation spectroscopy (PCCS), gel filtration and gas chromatography (GC). Results showed that the variation in the amount of ingredients affected geranium oil loading capacity and mean particle size. Increasing the concentrations of lipid, emulsifier and co-emulsifier resulted in the increase in the mean particle size from 46 nm to 114 nm. Geranium oil encapsulation efficiency (EE) was in the range of 92-99% (w/w). Production of high quality SLNS loaded with geranium oil has been demonstrated. Faculty of Chemical and Natural Resource Engineering, UTM 2008-10 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/12241/1/SAsnawi_FormulationofGeraniumOilLoadedSolidLipid2008.pdf Asnawi, S. and Abd. Aziz, A. and Abd. Aziz, R. and Khamis, A. K. (2008) Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application. Journal of Chemical & Natural Resources Engineering, 2 . pp. 90-99. ISSN 1823-5255
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Asnawi, S.
Abd. Aziz, A.
Abd. Aziz, R.
Khamis, A. K.
Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
description In recent years, essential oil has been the subject matter of many investigations due to its eco-friendly and bio-degradable nature. Geranium oil is one of the various essential oils that are used as mosquito repellent. However, stability is one of the issues related to essential oil fonnulations. Incorporation of essential oil in a control-release formulation could solve the problem and it also offers several advantages. In this work, a new delivery system for mosquito repellent based on the incorporation of geranium oil into solid lipid nanoparticles (SLNs) has been studied. The following has been employed for the production of geranium oil loaded solid lipid nanoparticles (GO-SLNs): 5-15% (w/w) stearic acid as the lipid, 0.5-3% (w/w) soy lecithin as the emulsifier, 0.5-3% (w/w) Tween 80 as the co-emulsifier, 5-20% (w/w) dichloromethane also as the co-emulsifier and 8% (w/w) geranium oil as the active ingredient. GO-SLNs were prepared using ultrasonicsolvent emulsification technique. GO-SLNS were characterized using transmission electron microscopy (TEM), photon cross correlation spectroscopy (PCCS), gel filtration and gas chromatography (GC). Results showed that the variation in the amount of ingredients affected geranium oil loading capacity and mean particle size. Increasing the concentrations of lipid, emulsifier and co-emulsifier resulted in the increase in the mean particle size from 46 nm to 114 nm. Geranium oil encapsulation efficiency (EE) was in the range of 92-99% (w/w). Production of high quality SLNS loaded with geranium oil has been demonstrated.
format Article
author Asnawi, S.
Abd. Aziz, A.
Abd. Aziz, R.
Khamis, A. K.
author_facet Asnawi, S.
Abd. Aziz, A.
Abd. Aziz, R.
Khamis, A. K.
author_sort Asnawi, S.
title Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
title_short Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
title_full Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
title_fullStr Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
title_full_unstemmed Formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
title_sort formulation of geranium oil loaded solid lipid nanoparticles for mosquito repellent application
publisher Faculty of Chemical and Natural Resource Engineering, UTM
publishDate 2008
url http://eprints.utm.my/id/eprint/12241/1/SAsnawi_FormulationofGeraniumOilLoadedSolidLipid2008.pdf
http://eprints.utm.my/id/eprint/12241/
_version_ 1643645898888052736
score 13.211869

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