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Tapered angle microfluidic device for cell separation using hydrodynamic principle

Cell sorting is an essential technique used in a wide range of research, diagnostic, and therapeutic sectors. Fluorescence-activated cell sorting (FACS), magnetic-activated cell sorting (MACS), and CellSearch, which are conventional techniques, possess inherent limitations. For instance, the utiliza...

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Main Authors: Jamrus, Muhammad Asyraf, Ahmad, Mohd. Ridzuan
格式: Article
語言:English
出版: Penerbit UTM Press 2024
主題:
TK Electrical engineering. Electronics Nuclear engineering
在線閱讀:http://eprints.utm.my/109077/1/MohdRidzuanAhmad2024_TaperedAngleMicrofluidicDeviceforCell.pdf
http://eprints.utm.my/109077/
http://dx.doi.org/10.11113/jurnalteknologi.v86.19449
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spelling my.utm.1090772025-01-28T08:22:13Z http://eprints.utm.my/109077/ Tapered angle microfluidic device for cell separation using hydrodynamic principle Jamrus, Muhammad Asyraf Ahmad, Mohd. Ridzuan TK Electrical engineering. Electronics Nuclear engineering Cell sorting is an essential technique used in a wide range of research, diagnostic, and therapeutic sectors. Fluorescence-activated cell sorting (FACS), magnetic-activated cell sorting (MACS), and CellSearch, which are conventional techniques, possess inherent limitations. For instance, the utilization of EpCam was ineffective in identifying specific malignancies. Cell sorting techniques have undergone significant advancements, with microfluidics being one of them. Regrettably, the current devices suffer from issues such as clogging and necessitate a lengthy main channel. Therefore, the goal of this work is to build and improve a microfluidic device with a tapered angle. There are three designs presented, each with one inlet, at least two exits, one focusing zone, and one tapering region. Using the finite element simulation software COMSOL Multiphysics, two studies are undertaken, the first examining the effect of taper angle on particle separation, and the second analyzing the effect of flow rate on particle separation. Based on the hydrodynamic theory and sedimentation process, this design allows particles to separate. When the taper angle approached 20 degrees, a mixture of 3 μm and 10 μm polystyrene microbeads were successfully separated, and separation continued until the taper angle approached 89 degrees. This technology offers simple, label-free, and continuous separation of many particles in a self-contained device without the use of bulky gear. Penerbit UTM Press 2024-07 Article PeerReviewed application/pdf en http://eprints.utm.my/109077/1/MohdRidzuanAhmad2024_TaperedAngleMicrofluidicDeviceforCell.pdf Jamrus, Muhammad Asyraf and Ahmad, Mohd. Ridzuan (2024) Tapered angle microfluidic device for cell separation using hydrodynamic principle. Jurnal Teknologi, 86 (4). pp. 105-114. ISSN 0127-9696 http://dx.doi.org/10.11113/jurnalteknologi.v86.19449 DOI:10.11113/jurnalteknologi.v86.19449
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TK Electrical engineering. Electronics Nuclear engineering
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
Jamrus, Muhammad Asyraf
Ahmad, Mohd. Ridzuan
Tapered angle microfluidic device for cell separation using hydrodynamic principle
description Cell sorting is an essential technique used in a wide range of research, diagnostic, and therapeutic sectors. Fluorescence-activated cell sorting (FACS), magnetic-activated cell sorting (MACS), and CellSearch, which are conventional techniques, possess inherent limitations. For instance, the utilization of EpCam was ineffective in identifying specific malignancies. Cell sorting techniques have undergone significant advancements, with microfluidics being one of them. Regrettably, the current devices suffer from issues such as clogging and necessitate a lengthy main channel. Therefore, the goal of this work is to build and improve a microfluidic device with a tapered angle. There are three designs presented, each with one inlet, at least two exits, one focusing zone, and one tapering region. Using the finite element simulation software COMSOL Multiphysics, two studies are undertaken, the first examining the effect of taper angle on particle separation, and the second analyzing the effect of flow rate on particle separation. Based on the hydrodynamic theory and sedimentation process, this design allows particles to separate. When the taper angle approached 20 degrees, a mixture of 3 μm and 10 μm polystyrene microbeads were successfully separated, and separation continued until the taper angle approached 89 degrees. This technology offers simple, label-free, and continuous separation of many particles in a self-contained device without the use of bulky gear.
format Article
author Jamrus, Muhammad Asyraf
Ahmad, Mohd. Ridzuan
author_facet Jamrus, Muhammad Asyraf
Ahmad, Mohd. Ridzuan
author_sort Jamrus, Muhammad Asyraf
title Tapered angle microfluidic device for cell separation using hydrodynamic principle
title_short Tapered angle microfluidic device for cell separation using hydrodynamic principle
title_full Tapered angle microfluidic device for cell separation using hydrodynamic principle
title_fullStr Tapered angle microfluidic device for cell separation using hydrodynamic principle
title_full_unstemmed Tapered angle microfluidic device for cell separation using hydrodynamic principle
title_sort tapered angle microfluidic device for cell separation using hydrodynamic principle
publisher Penerbit UTM Press
publishDate 2024
url http://eprints.utm.my/109077/1/MohdRidzuanAhmad2024_TaperedAngleMicrofluidicDeviceforCell.pdf
http://eprints.utm.my/109077/
http://dx.doi.org/10.11113/jurnalteknologi.v86.19449
_version_ 1827439211467243520
score 13.251813

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