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Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis

Multiple-step on-line preconcentration, a combination of at least two stacking techniques has been developed to increase the sensitivity in capillary electrophoresis (CE) for analytes in various samples. It is usually conducted sequentially, or in some cases, synergistically, where different stackin...

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Main Authors: Abdul Keyon, Aemi Syazwani, Ng, Nyuk Ting, Breadmore, Michael Charles
Format: Article
Published: John Wiley & Sons Inc 2024
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/108929/
http://dx.doi.org/10.1002/jssc.202400519
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spelling my.utm.1089292024-12-15T06:07:29Z http://eprints.utm.my/108929/ Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis Abdul Keyon, Aemi Syazwani Ng, Nyuk Ting Breadmore, Michael Charles QD Chemistry Multiple-step on-line preconcentration, a combination of at least two stacking techniques has been developed to increase the sensitivity in capillary electrophoresis (CE) for analytes in various samples. It is usually conducted sequentially, or in some cases, synergistically, where different stacking modes occur simultaneously. Multiple-step techniques allow simultaneous preconcentration and separation of various kinds of analytes in different complex samples in a single CE run. This review aims to provide recent advances in multiple-step on-line preconcentration techniques in CE. We critically review technical papers published for the last 7 years up until July 2024, subsequently organized according to the combination of the main stacking techniques, that is, field amplification, large volume sample stacking, transient isotachophoresis, micelle to solvent or micelle to cyclodextrin stacking, and others. The procedures, fundamental mechanism, analytical figures of merits achieved, and their feasibility for complicated sample matrices are reviewed. John Wiley & Sons Inc 2024-09 Article PeerReviewed Abdul Keyon, Aemi Syazwani and Ng, Nyuk Ting and Breadmore, Michael Charles (2024) Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis. Journal of Separation Science, 47 (18). NA. ISSN 1615-9306 http://dx.doi.org/10.1002/jssc.202400519 DOI:10.1002/jssc.202400519
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Abdul Keyon, Aemi Syazwani
Ng, Nyuk Ting
Breadmore, Michael Charles
Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
description Multiple-step on-line preconcentration, a combination of at least two stacking techniques has been developed to increase the sensitivity in capillary electrophoresis (CE) for analytes in various samples. It is usually conducted sequentially, or in some cases, synergistically, where different stacking modes occur simultaneously. Multiple-step techniques allow simultaneous preconcentration and separation of various kinds of analytes in different complex samples in a single CE run. This review aims to provide recent advances in multiple-step on-line preconcentration techniques in CE. We critically review technical papers published for the last 7 years up until July 2024, subsequently organized according to the combination of the main stacking techniques, that is, field amplification, large volume sample stacking, transient isotachophoresis, micelle to solvent or micelle to cyclodextrin stacking, and others. The procedures, fundamental mechanism, analytical figures of merits achieved, and their feasibility for complicated sample matrices are reviewed.
format Article
author Abdul Keyon, Aemi Syazwani
Ng, Nyuk Ting
Breadmore, Michael Charles
author_facet Abdul Keyon, Aemi Syazwani
Ng, Nyuk Ting
Breadmore, Michael Charles
author_sort Abdul Keyon, Aemi Syazwani
title Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
title_short Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
title_full Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
title_fullStr Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
title_full_unstemmed Advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
title_sort advancements in multiple-step on-line preconcentration techniques for enhanced sensitivity in capillary electrophoresis
publisher John Wiley & Sons Inc
publishDate 2024
url http://eprints.utm.my/108929/
http://dx.doi.org/10.1002/jssc.202400519
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score 13.244413

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