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Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.

Electrospray is a novel and versatile approach to the synthesis of nanosized particles. In this paper, the effects of electrospray process parameters such as gauge size (18 G-25 G) and flow rate(0.9-1.5 ml hr-1) on droplet surface tension and electrosprayparticle size were evaluated. 25 mg P...

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Main Authors: Shakri, Adibah, Shawaludin, Muhammad Ayman Ikmal, Mohamed Suffian, Izzat Fahimuddin, Farikhah, Irna, Mohd Pa’ad, Khairunnisa
Format: Article
Language:English
Published: Penerbit UTM Press 2023
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/108736/1/AdibahShakri2023_PolyLacticcoGlycolicAcidNanoparticlesFlowRates.pdf
http://eprints.utm.my/108736/
http://dx.doi.org/10.37934/jrnn.9.1.112
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spelling my.utm.1087362024-11-27T09:47:12Z http://eprints.utm.my/108736/ Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing. Shakri, Adibah Shawaludin, Muhammad Ayman Ikmal Mohamed Suffian, Izzat Fahimuddin Farikhah, Irna Mohd Pa’ad, Khairunnisa TP Chemical technology Electrospray is a novel and versatile approach to the synthesis of nanosized particles. In this paper, the effects of electrospray process parameters such as gauge size (18 G-25 G) and flow rate(0.9-1.5 ml hr-1) on droplet surface tension and electrosprayparticle size were evaluated. 25 mg Poly Lactic-co-Glycolic Acid (PLGA) were dissolvedin 100 ml acetone before being subjected to electrospray. Tate’s Law was used to calculate the surface tension while the Malvern nanosizer was used to measure the particle size. Based on Tate’s Law calculation, when the gauze size increased from 18 G-25 G, the droplet surface tension increased from 10.07 Nm-1to 18.17 Nm-1showing adirect pattern. At the same time,the flowrate is inversely proportional to droplet surface tension. When the flow rate increased from 0.9-1.5 ml hr-1, the droplet surface tension was reduced. This is due to the increasing ratio of vicious force and surface tension.For particle size, as surface tension increased from 10.07 Nm-1to 18.17 Nm-1, particle size increased from 205.57 nm to 612 nm owing to the corona discharge producing larger progeny droplets that chain into smaller particles through coulomb fission as more charge is required to overcome the surface tension. In conclusion, flow rate and gauge size influenced the surface tension thus affecting the nanosized particles. Penerbit UTM Press 2023-12-08 Article PeerReviewed application/pdf en http://eprints.utm.my/108736/1/AdibahShakri2023_PolyLacticcoGlycolicAcidNanoparticlesFlowRates.pdf Shakri, Adibah and Shawaludin, Muhammad Ayman Ikmal and Mohamed Suffian, Izzat Fahimuddin and Farikhah, Irna and Mohd Pa’ad, Khairunnisa (2023) Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing. Journal of Research in Nanoscience and Nanotechnology, 9 (1). pp. 1-12. ISSN 2773-6180 http://dx.doi.org/10.37934/jrnn.9.1.112 DOI:10.37934/jrnn.9.1.112
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Shakri, Adibah
Shawaludin, Muhammad Ayman Ikmal
Mohamed Suffian, Izzat Fahimuddin
Farikhah, Irna
Mohd Pa’ad, Khairunnisa
Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
description Electrospray is a novel and versatile approach to the synthesis of nanosized particles. In this paper, the effects of electrospray process parameters such as gauge size (18 G-25 G) and flow rate(0.9-1.5 ml hr-1) on droplet surface tension and electrosprayparticle size were evaluated. 25 mg Poly Lactic-co-Glycolic Acid (PLGA) were dissolvedin 100 ml acetone before being subjected to electrospray. Tate’s Law was used to calculate the surface tension while the Malvern nanosizer was used to measure the particle size. Based on Tate’s Law calculation, when the gauze size increased from 18 G-25 G, the droplet surface tension increased from 10.07 Nm-1to 18.17 Nm-1showing adirect pattern. At the same time,the flowrate is inversely proportional to droplet surface tension. When the flow rate increased from 0.9-1.5 ml hr-1, the droplet surface tension was reduced. This is due to the increasing ratio of vicious force and surface tension.For particle size, as surface tension increased from 10.07 Nm-1to 18.17 Nm-1, particle size increased from 205.57 nm to 612 nm owing to the corona discharge producing larger progeny droplets that chain into smaller particles through coulomb fission as more charge is required to overcome the surface tension. In conclusion, flow rate and gauge size influenced the surface tension thus affecting the nanosized particles.
format Article
author Shakri, Adibah
Shawaludin, Muhammad Ayman Ikmal
Mohamed Suffian, Izzat Fahimuddin
Farikhah, Irna
Mohd Pa’ad, Khairunnisa
author_facet Shakri, Adibah
Shawaludin, Muhammad Ayman Ikmal
Mohamed Suffian, Izzat Fahimuddin
Farikhah, Irna
Mohd Pa’ad, Khairunnisa
author_sort Shakri, Adibah
title Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
title_short Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
title_full Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
title_fullStr Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
title_full_unstemmed Poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
title_sort poly lactic-co-glycolic acid nanoparticles: flow ratesand gauge sizesinfluence the droplet surface tension and particle sizing.
publisher Penerbit UTM Press
publishDate 2023
url http://eprints.utm.my/108736/1/AdibahShakri2023_PolyLacticcoGlycolicAcidNanoparticlesFlowRates.pdf
http://eprints.utm.my/108736/
http://dx.doi.org/10.37934/jrnn.9.1.112
_version_ 1817841638894993408
score 13.223943

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