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Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices

Biomaterial-Centered Infection (BCI) is a significant issue in the implantation of medical devices, primarily caused by the formation of bacterial biofilms on the device surface. One potential solution to address this problem is the use of antibacterial coatings. This study examines the effectivenes...

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Main Authors: Khrisna, Dida Faadihilah, Jumat, Mohamad Amin, Jemon, Khairunadwa, Saidin, Syafiqah
Format: Article
Language:English
Published: Penerbit UTM Press 2023
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.utm.my/108612/1/DidaFaadihilahKhrisna2023_AntibacterialAnalysisonEverolimusGraftedSurfaces.pdf
http://eprints.utm.my/108612/
http://dx.doi.org/10.11113/humentech.v2n2.52
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spelling my.utm.1086122024-11-20T08:04:05Z http://eprints.utm.my/108612/ Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices Khrisna, Dida Faadihilah Jumat, Mohamad Amin Jemon, Khairunadwa Saidin, Syafiqah Q Science (General) QD Chemistry Biomaterial-Centered Infection (BCI) is a significant issue in the implantation of medical devices, primarily caused by the formation of bacterial biofilms on the device surface. One potential solution to address this problem is the use of antibacterial coatings. This study examines the effectiveness of everolimus as an antibacterial coating agent with polydopamine (PDA) as an intermediate layer. The commonly used biomaterial for medical scaffolds, poly(lactic acid) (PLA), was coated with everolimus after being submerged in PDA for 24 hours. The coated PLA was then subjected to antibacterial analysis, including culturing Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria in Luria-Bertani broth, bacterial count tests, and disc inhibition tests. The results showed that everolimus has antibacterial properties, but its efficacy varies with different types of bacteria adhering to the biomaterial surfaces. Specifically, the everolimus coating was found to be more effective in killing Gram-positive S. aureus. The absence of inhibition zones and the lack of further growth of both Gram-positive S. aureus and Gram-negative E. coli on the samples demonstrated the controlled release of everolimus, indicating the potential of the PDA layer in holding the everolimus release to the surrounding. Therefore, the study concludes that the formation of everolimus coating on biomaterial surfaces aided by the PDA layer, have significant potential in retarding bacterial colonies on medical devices. Penerbit UTM Press 2023-08-06 Article PeerReviewed application/pdf en http://eprints.utm.my/108612/1/DidaFaadihilahKhrisna2023_AntibacterialAnalysisonEverolimusGraftedSurfaces.pdf Khrisna, Dida Faadihilah and Jumat, Mohamad Amin and Jemon, Khairunadwa and Saidin, Syafiqah (2023) Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices. Journal of Human Centered Technology, 2 (2). pp. 11-18. ISSN 2821-3467 http://dx.doi.org/10.11113/humentech.v2n2.52 DOI:10.11113/humentech.v2n2.52
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Khrisna, Dida Faadihilah
Jumat, Mohamad Amin
Jemon, Khairunadwa
Saidin, Syafiqah
Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
description Biomaterial-Centered Infection (BCI) is a significant issue in the implantation of medical devices, primarily caused by the formation of bacterial biofilms on the device surface. One potential solution to address this problem is the use of antibacterial coatings. This study examines the effectiveness of everolimus as an antibacterial coating agent with polydopamine (PDA) as an intermediate layer. The commonly used biomaterial for medical scaffolds, poly(lactic acid) (PLA), was coated with everolimus after being submerged in PDA for 24 hours. The coated PLA was then subjected to antibacterial analysis, including culturing Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria in Luria-Bertani broth, bacterial count tests, and disc inhibition tests. The results showed that everolimus has antibacterial properties, but its efficacy varies with different types of bacteria adhering to the biomaterial surfaces. Specifically, the everolimus coating was found to be more effective in killing Gram-positive S. aureus. The absence of inhibition zones and the lack of further growth of both Gram-positive S. aureus and Gram-negative E. coli on the samples demonstrated the controlled release of everolimus, indicating the potential of the PDA layer in holding the everolimus release to the surrounding. Therefore, the study concludes that the formation of everolimus coating on biomaterial surfaces aided by the PDA layer, have significant potential in retarding bacterial colonies on medical devices.
format Article
author Khrisna, Dida Faadihilah
Jumat, Mohamad Amin
Jemon, Khairunadwa
Saidin, Syafiqah
author_facet Khrisna, Dida Faadihilah
Jumat, Mohamad Amin
Jemon, Khairunadwa
Saidin, Syafiqah
author_sort Khrisna, Dida Faadihilah
title Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
title_short Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
title_full Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
title_fullStr Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
title_full_unstemmed Antibacterial Analysis on Everolimus Grafted Surfacesusing Polydopamine Intermediate Layerfor Potential Use on Medical Devices
title_sort antibacterial analysis on everolimus grafted surfacesusing polydopamine intermediate layerfor potential use on medical devices
publisher Penerbit UTM Press
publishDate 2023
url http://eprints.utm.my/108612/1/DidaFaadihilahKhrisna2023_AntibacterialAnalysisonEverolimusGraftedSurfaces.pdf
http://eprints.utm.my/108612/
http://dx.doi.org/10.11113/humentech.v2n2.52
_version_ 1817841620251312128
score 13.223943

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