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The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual

Background: This multicenter, three-armed, parallel, single-blind randomized controlled trial (RCT) primarily aims to compare the efficacy of virtual reality exposure therapy (VRET) with that of acceptance and commitment therapy (ACT) and treatment as usual (TAU) to depreciate the degree of alcohol...

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Main Authors: Deng, Hongdu, Zhang, Ruiling, Wang, Chuansheng, Zhang, Bingyu, Wang, Jiali, Wang, Shilin, Zhang, Jie, Shari, Nurul Izzah, Abdullah, Mohammad Farris Iman Leong
Format: Article
Language:English
Published: Frontiers Media SA 2023
Subjects:
H Social Sciences (General)
Online Access:http://eprints.utm.my/107455/1/NurulIzzahShari2023_TheEfficacyOfVirtualRealityExposureTherapy.pdf
http://eprints.utm.my/107455/
http://dx.doi.org/10.3389/fpsyt.2023.1215963
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spelling my.utm.1074552024-09-18T06:30:01Z http://eprints.utm.my/107455/ The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual Deng, Hongdu Zhang, Ruiling Wang, Chuansheng Zhang, Bingyu Wang, Jiali Wang, Shilin Zhang, Jie Shari, Nurul Izzah Abdullah, Mohammad Farris Iman Leong H Social Sciences (General) Background: This multicenter, three-armed, parallel, single-blind randomized controlled trial (RCT) primarily aims to compare the efficacy of virtual reality exposure therapy (VRET) with that of acceptance and commitment therapy (ACT) and treatment as usual (TAU) to depreciate the degree of alcohol craving among alcohol use disorder patients who have undergone in-patient detoxification across four timelines (t0 = baseline prior to intervention, t1 = 4 weeks after baseline, t2 = 12 weeks after baseline, and t3 = 24 weeks after baseline). The secondary aims of this RCT are to compare the efficacy of VRET with that of ACT and TAU to alleviate the severity of alcohol use disorder, dissipate comorbid depressive and anxiety symptoms, and normalize event-related potential (ERP) in electroencephalogram (EEG) monitoring across the four timelines. Methods: Initially, after 2 weeks of in-patient detoxification, 120 patients with alcohol use disorder will be randomized into three groups (VRET, ACT, and TAU control groups) via stratified permuted block randomization in a 1:1:1 ratio. Baseline assessment (t0) commences, whereby all the participants will be administered with sociodemographic, clinical, and alcohol use characteristics questionnaire, such as Alcohol Use Disorder Identification Test (AUDIT), Penn Alcohol Craving Scale (PACS), Hamilton Anxiety Rating Scale (HAM-A), and Hamilton Depression Rating Scale (HAM-D), while event-related potential (ERP) detection in electroencephalogram (EEG) will also be carried out. Then, 4 weeks of VRET, ACT, and non-therapeutic supportive activities will be conducted in the three respective groups. For the subsequent three assessment timelines (t1, t2, and t3), the alcohol use characteristic questionnaire, such as AUDIT, PACS, HAM-D, HAM-A, and ERP monitoring, will be re-administered to all participants. Discussion: As data on the effects of non-pharmacological interventions, such as VRET and ACT, on the treatment of alcohol craving and preventing relapse in alcohol use disorder are lacking, this RCT fills the research gap by providing these important data to treating clinicians. If proven efficacious, the efficacy of VRET and ACT for the treatment of other substance use disorders should also be investigated in future. Frontiers Media SA 2023 Article PeerReviewed application/pdf en http://eprints.utm.my/107455/1/NurulIzzahShari2023_TheEfficacyOfVirtualRealityExposureTherapy.pdf Deng, Hongdu and Zhang, Ruiling and Wang, Chuansheng and Zhang, Bingyu and Wang, Jiali and Wang, Shilin and Zhang, Jie and Shari, Nurul Izzah and Abdullah, Mohammad Farris Iman Leong (2023) The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual. Frontiers in Psychiatry, 14 (NA). pp. 1-11. ISSN 1664-0640 http://dx.doi.org/10.3389/fpsyt.2023.1215963 DOI : 10.3389/fpsyt.2023.1215963
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic H Social Sciences (General)
spellingShingle H Social Sciences (General)
Deng, Hongdu
Zhang, Ruiling
Wang, Chuansheng
Zhang, Bingyu
Wang, Jiali
Wang, Shilin
Zhang, Jie
Shari, Nurul Izzah
Abdullah, Mohammad Farris Iman Leong
The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
description Background: This multicenter, three-armed, parallel, single-blind randomized controlled trial (RCT) primarily aims to compare the efficacy of virtual reality exposure therapy (VRET) with that of acceptance and commitment therapy (ACT) and treatment as usual (TAU) to depreciate the degree of alcohol craving among alcohol use disorder patients who have undergone in-patient detoxification across four timelines (t0 = baseline prior to intervention, t1 = 4 weeks after baseline, t2 = 12 weeks after baseline, and t3 = 24 weeks after baseline). The secondary aims of this RCT are to compare the efficacy of VRET with that of ACT and TAU to alleviate the severity of alcohol use disorder, dissipate comorbid depressive and anxiety symptoms, and normalize event-related potential (ERP) in electroencephalogram (EEG) monitoring across the four timelines. Methods: Initially, after 2 weeks of in-patient detoxification, 120 patients with alcohol use disorder will be randomized into three groups (VRET, ACT, and TAU control groups) via stratified permuted block randomization in a 1:1:1 ratio. Baseline assessment (t0) commences, whereby all the participants will be administered with sociodemographic, clinical, and alcohol use characteristics questionnaire, such as Alcohol Use Disorder Identification Test (AUDIT), Penn Alcohol Craving Scale (PACS), Hamilton Anxiety Rating Scale (HAM-A), and Hamilton Depression Rating Scale (HAM-D), while event-related potential (ERP) detection in electroencephalogram (EEG) will also be carried out. Then, 4 weeks of VRET, ACT, and non-therapeutic supportive activities will be conducted in the three respective groups. For the subsequent three assessment timelines (t1, t2, and t3), the alcohol use characteristic questionnaire, such as AUDIT, PACS, HAM-D, HAM-A, and ERP monitoring, will be re-administered to all participants. Discussion: As data on the effects of non-pharmacological interventions, such as VRET and ACT, on the treatment of alcohol craving and preventing relapse in alcohol use disorder are lacking, this RCT fills the research gap by providing these important data to treating clinicians. If proven efficacious, the efficacy of VRET and ACT for the treatment of other substance use disorders should also be investigated in future.
format Article
author Deng, Hongdu
Zhang, Ruiling
Wang, Chuansheng
Zhang, Bingyu
Wang, Jiali
Wang, Shilin
Zhang, Jie
Shari, Nurul Izzah
Abdullah, Mohammad Farris Iman Leong
author_facet Deng, Hongdu
Zhang, Ruiling
Wang, Chuansheng
Zhang, Bingyu
Wang, Jiali
Wang, Shilin
Zhang, Jie
Shari, Nurul Izzah
Abdullah, Mohammad Farris Iman Leong
author_sort Deng, Hongdu
title The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
title_short The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
title_full The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
title_fullStr The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
title_full_unstemmed The efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
title_sort efficacy of virtual reality exposure therapy for the treatment of alcohol use disorder among adult males: a randomized controlled trial comparing with acceptance and commitment therapy and treatment as usual
publisher Frontiers Media SA
publishDate 2023
url http://eprints.utm.my/107455/1/NurulIzzahShari2023_TheEfficacyOfVirtualRealityExposureTherapy.pdf
http://eprints.utm.my/107455/
http://dx.doi.org/10.3389/fpsyt.2023.1215963
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score 13.211869

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