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Awareness raising and dealing with methanol poisoning based on effective strategies

Intoxication with methanol most commonly occurs as a consequence of ingesting, inhaling, or coming into contact with formulations that include methanol as a base. Clinical manifestations of methanol poisoning include suppression of the central nervous system, gastrointestinal symptoms, and decompens...

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Main Authors:	Jangjou, Ali, Moqadas, Mostafa, Mohsenian, Leila, Kamyab, Hesam, Chelliapan, Shreeshivadasan, Alshehery, Sultan, Ali, Mohammed Azam, Dehbozorgi, Farbod, Yadav, Krishna Kumar, Khorami, Masoud, Jelyani, Najmeh Zarei
Format:	Article
Published:	Academic Press Inc. 2023
Subjects:	T Technology (General)
Online Access:	http://eprints.utm.my/107271/ http://dx.doi.org/10.1016/j.envres.2023.115886
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spelling	my.utm.1072712024-09-01T06:36:22Z http://eprints.utm.my/107271/ Awareness raising and dealing with methanol poisoning based on effective strategies Jangjou, Ali Moqadas, Mostafa Mohsenian, Leila Kamyab, Hesam Chelliapan, Shreeshivadasan Alshehery, Sultan Ali, Mohammed Azam Dehbozorgi, Farbod Yadav, Krishna Kumar Khorami, Masoud Jelyani, Najmeh Zarei T Technology (General) Intoxication with methanol most commonly occurs as a consequence of ingesting, inhaling, or coming into contact with formulations that include methanol as a base. Clinical manifestations of methanol poisoning include suppression of the central nervous system, gastrointestinal symptoms, and decompensated metabolic acidosis, which is associated with impaired vision and either early or late blindness within 0.5–4 h after ingestion. After ingestion, methanol concentrations in the blood that are greater than 50 mg/dl should raise some concern. Ingested methanol is typically digested by alcohol dehydrogenase (ADH), and it is subsequently redistributed to the body's water to attain a volume distribution that is about equivalent to 0.77 L/kg. Moreover, it is removed from the body as its natural, unchanged parent molecules. Due to the fact that methanol poisoning is relatively uncommon but frequently involves a large number of victims at the same time, this type of incident occupies a special position in the field of clinical toxicology. The beginning of the COVID-19 pandemic has resulted in an increase in erroneous assumptions regarding the preventative capability of methanol in comparison to viral infection. More than 1000 Iranians fell ill, and more than 300 of them passed away in March of this year after they consumed methanol in the expectation that it would protect them from a new coronavirus. The Atlanta epidemic, which involved 323 individuals and resulted in the deaths of 41, is one example of mass poisoning. Another example is the Kristiansand outbreak, which involved 70 people and resulted in the deaths of three. In 2003, the AAPCC received reports of more than one thousand pediatric exposures. Since methanol poisoning is associated with high mortality rates, it is vital that the condition be addressed seriously and managed as quickly as feasible. The objective of this review was to raise awareness about the mechanism and metabolism of methanol toxicity, the introduction of therapeutic interventions such as gastrointestinal decontamination and methanol metabolism inhibition, the correction of metabolic disturbances, and the establishment of novel diagnostic/screening nanoparticle-based strategies for methanol poisoning such as the discovery of ADH inhibitors as well as the detection of the adulteration of alcoholic drinks by nanoparticles in order to prevent methanol poisoning. In conclusion, increasing warnings and knowledge about clinical manifestations, medical interventions, and novel strategies for methanol poisoning probably results in a decrease in the death load. Academic Press Inc. 2023 Article PeerReviewed Jangjou, Ali and Moqadas, Mostafa and Mohsenian, Leila and Kamyab, Hesam and Chelliapan, Shreeshivadasan and Alshehery, Sultan and Ali, Mohammed Azam and Dehbozorgi, Farbod and Yadav, Krishna Kumar and Khorami, Masoud and Jelyani, Najmeh Zarei (2023) Awareness raising and dealing with methanol poisoning based on effective strategies. Environmental Research, 228 (NA). NA-NA. ISSN 0013-9351 http://dx.doi.org/10.1016/j.envres.2023.115886 DOI : 10.1016/j.envres.2023.115886
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	T Technology (General)
spellingShingle	T Technology (General) Jangjou, Ali Moqadas, Mostafa Mohsenian, Leila Kamyab, Hesam Chelliapan, Shreeshivadasan Alshehery, Sultan Ali, Mohammed Azam Dehbozorgi, Farbod Yadav, Krishna Kumar Khorami, Masoud Jelyani, Najmeh Zarei Awareness raising and dealing with methanol poisoning based on effective strategies
description	Intoxication with methanol most commonly occurs as a consequence of ingesting, inhaling, or coming into contact with formulations that include methanol as a base. Clinical manifestations of methanol poisoning include suppression of the central nervous system, gastrointestinal symptoms, and decompensated metabolic acidosis, which is associated with impaired vision and either early or late blindness within 0.5–4 h after ingestion. After ingestion, methanol concentrations in the blood that are greater than 50 mg/dl should raise some concern. Ingested methanol is typically digested by alcohol dehydrogenase (ADH), and it is subsequently redistributed to the body's water to attain a volume distribution that is about equivalent to 0.77 L/kg. Moreover, it is removed from the body as its natural, unchanged parent molecules. Due to the fact that methanol poisoning is relatively uncommon but frequently involves a large number of victims at the same time, this type of incident occupies a special position in the field of clinical toxicology. The beginning of the COVID-19 pandemic has resulted in an increase in erroneous assumptions regarding the preventative capability of methanol in comparison to viral infection. More than 1000 Iranians fell ill, and more than 300 of them passed away in March of this year after they consumed methanol in the expectation that it would protect them from a new coronavirus. The Atlanta epidemic, which involved 323 individuals and resulted in the deaths of 41, is one example of mass poisoning. Another example is the Kristiansand outbreak, which involved 70 people and resulted in the deaths of three. In 2003, the AAPCC received reports of more than one thousand pediatric exposures. Since methanol poisoning is associated with high mortality rates, it is vital that the condition be addressed seriously and managed as quickly as feasible. The objective of this review was to raise awareness about the mechanism and metabolism of methanol toxicity, the introduction of therapeutic interventions such as gastrointestinal decontamination and methanol metabolism inhibition, the correction of metabolic disturbances, and the establishment of novel diagnostic/screening nanoparticle-based strategies for methanol poisoning such as the discovery of ADH inhibitors as well as the detection of the adulteration of alcoholic drinks by nanoparticles in order to prevent methanol poisoning. In conclusion, increasing warnings and knowledge about clinical manifestations, medical interventions, and novel strategies for methanol poisoning probably results in a decrease in the death load.
format	Article
author	Jangjou, Ali Moqadas, Mostafa Mohsenian, Leila Kamyab, Hesam Chelliapan, Shreeshivadasan Alshehery, Sultan Ali, Mohammed Azam Dehbozorgi, Farbod Yadav, Krishna Kumar Khorami, Masoud Jelyani, Najmeh Zarei
author_facet	Jangjou, Ali Moqadas, Mostafa Mohsenian, Leila Kamyab, Hesam Chelliapan, Shreeshivadasan Alshehery, Sultan Ali, Mohammed Azam Dehbozorgi, Farbod Yadav, Krishna Kumar Khorami, Masoud Jelyani, Najmeh Zarei
author_sort	Jangjou, Ali
title	Awareness raising and dealing with methanol poisoning based on effective strategies
title_short	Awareness raising and dealing with methanol poisoning based on effective strategies
title_full	Awareness raising and dealing with methanol poisoning based on effective strategies
title_fullStr	Awareness raising and dealing with methanol poisoning based on effective strategies
title_full_unstemmed	Awareness raising and dealing with methanol poisoning based on effective strategies
title_sort	awareness raising and dealing with methanol poisoning based on effective strategies
publisher	Academic Press Inc.
publishDate	2023
url	http://eprints.utm.my/107271/ http://dx.doi.org/10.1016/j.envres.2023.115886
_version_	1809136650649862144
score	13.211869

Awareness raising and dealing with methanol poisoning based on effective strategies

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