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Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies

Anthracyclines are one of the most effective cancer treatments ever created, but these compounds are somewhat cardiotoxic to some patients, causing heart failure. The likeli-hood of such adverse effects restricts the overall prescribed dose of anthracyclines for pa-tients. Based on the pathophysiolo...

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Main Authors: Hussen, Narmin Hamaamin, Hasan, Aso Hameed, Muhammed, Gashbeen Osman, Yassin, Akar Yousif, Salih, Roza Rafiq, Ahmed Esmail, Parwa, Alanazi, Mohammed M., Jamalis, Joazaizulfazli
Format: Article
Published: Bentham Science Publishers 2023
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/106444/
http://dx.doi.org/10.2174/1385272827666230423144150
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spelling my.utm.1064442024-07-08T06:58:00Z http://eprints.utm.my/106444/ Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies Hussen, Narmin Hamaamin Hasan, Aso Hameed Muhammed, Gashbeen Osman Yassin, Akar Yousif Salih, Roza Rafiq Ahmed Esmail, Parwa Alanazi, Mohammed M. Jamalis, Joazaizulfazli QD Chemistry Anthracyclines are one of the most effective cancer treatments ever created, but these compounds are somewhat cardiotoxic to some patients, causing heart failure. The likeli-hood of such adverse effects restricts the overall prescribed dose of anthracyclines for pa-tients. Based on the pathophysiology of anthracycline-induced cardiotoxicity, the cardiotoxi-city plausibly originates from a reduction reaction of a single electron in its structure to form surplus reactive oxygen species (ROS) or two electrons reducing and converting into C-13 alcohol metabolites. While excess ROS is the probable cause for acute cardiotoxicity brought on by anthracyclines, it is not all characteristic of progressive cardiomyopathy. The formed secondary alcohol metabolites could also profoundly accelerate cardiotoxicity, which then develops into cardiomyopathy and eventually congestive heart failure. This review offers an overview of the molecular pathways of anthracycline-induced cardiotoxicity, emphasizing the roles of secondary alcohol metabolites of anthracyclines and/or their morbific role as ROS. The most effective ways to minimize or terminate anthracycline-induced cardiotoxicity are also covered. Bentham Science Publishers 2023 Article PeerReviewed Hussen, Narmin Hamaamin and Hasan, Aso Hameed and Muhammed, Gashbeen Osman and Yassin, Akar Yousif and Salih, Roza Rafiq and Ahmed Esmail, Parwa and Alanazi, Mohammed M. and Jamalis, Joazaizulfazli (2023) Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies. Current Organic Chemistry, 27 (4). pp. 363-377. ISSN 1385-2728 http://dx.doi.org/10.2174/1385272827666230423144150 DOI : 10.2174/1385272827666230423144150
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Hussen, Narmin Hamaamin
Hasan, Aso Hameed
Muhammed, Gashbeen Osman
Yassin, Akar Yousif
Salih, Roza Rafiq
Ahmed Esmail, Parwa
Alanazi, Mohammed M.
Jamalis, Joazaizulfazli
Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
description Anthracyclines are one of the most effective cancer treatments ever created, but these compounds are somewhat cardiotoxic to some patients, causing heart failure. The likeli-hood of such adverse effects restricts the overall prescribed dose of anthracyclines for pa-tients. Based on the pathophysiology of anthracycline-induced cardiotoxicity, the cardiotoxi-city plausibly originates from a reduction reaction of a single electron in its structure to form surplus reactive oxygen species (ROS) or two electrons reducing and converting into C-13 alcohol metabolites. While excess ROS is the probable cause for acute cardiotoxicity brought on by anthracyclines, it is not all characteristic of progressive cardiomyopathy. The formed secondary alcohol metabolites could also profoundly accelerate cardiotoxicity, which then develops into cardiomyopathy and eventually congestive heart failure. This review offers an overview of the molecular pathways of anthracycline-induced cardiotoxicity, emphasizing the roles of secondary alcohol metabolites of anthracyclines and/or their morbific role as ROS. The most effective ways to minimize or terminate anthracycline-induced cardiotoxicity are also covered.
format Article
author Hussen, Narmin Hamaamin
Hasan, Aso Hameed
Muhammed, Gashbeen Osman
Yassin, Akar Yousif
Salih, Roza Rafiq
Ahmed Esmail, Parwa
Alanazi, Mohammed M.
Jamalis, Joazaizulfazli
author_facet Hussen, Narmin Hamaamin
Hasan, Aso Hameed
Muhammed, Gashbeen Osman
Yassin, Akar Yousif
Salih, Roza Rafiq
Ahmed Esmail, Parwa
Alanazi, Mohammed M.
Jamalis, Joazaizulfazli
author_sort Hussen, Narmin Hamaamin
title Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
title_short Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
title_full Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
title_fullStr Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
title_full_unstemmed Anthracycline in medicinal chemistry: Mechanism of cardiotoxicity, preventive and treatment strategies
title_sort anthracycline in medicinal chemistry: mechanism of cardiotoxicity, preventive and treatment strategies
publisher Bentham Science Publishers
publishDate 2023
url http://eprints.utm.my/106444/
http://dx.doi.org/10.2174/1385272827666230423144150
_version_ 1804065501689675776
score 13.223943

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