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Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.

Andrographis paniculata is a well-known and highly used potential herbal plant for worldwide medicinal use. Plant studies reported that the leaf extract of A. paniculata, which has high antioxidant capacity, has antifungal, antimicrobial, antiprotozoal, antidiabetic, liver enzyme modulation, insecti...

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Main Authors: Adam, Rabe’ah, Ramli, Faiqah, Abdul Hamid, Mariani, Mohd. Bohari, Siti Pauliena
Format: Article
Language:English
Published: Open Science Publishers LLP Inc. 2023
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/106254/1/Rabe%27ahAdam2023_MelanpgenesisInhibitionEffectofEthanolicAndrographis.pdf
http://eprints.utm.my/106254/
http://dx.doi.org/10.7324/JAPS.2023.130107
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spelling my.utm.1062542024-06-20T02:52:50Z http://eprints.utm.my/106254/ Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression. Adam, Rabe’ah Ramli, Faiqah Abdul Hamid, Mariani Mohd. Bohari, Siti Pauliena TP Chemical technology Andrographis paniculata is a well-known and highly used potential herbal plant for worldwide medicinal use. Plant studies reported that the leaf extract of A. paniculata, which has high antioxidant capacity, has antifungal, antimicrobial, antiprotozoal, antidiabetic, liver enzyme modulation, insecticidal, and toxicity properties. Nevertheless, no report regarding its antimelanogenic activity is available. Hence, this study was carried out to investigate A. paniculata leaf extract potential of the antimelanogenic property. The data shown from this study proved that the A. paniculata leaf extract is responsible for melanin content reduction and decreases the protein expression of tyrosinase (TYR) and microphthalmia-associated transcription factor in B16F1 melanoma cells. This study found that the A. paniculata leaf extract acted powerfully in the synthesis of tyrosinase-related protein-2 inhibition. TYR is a well-known essential enzyme in melanogenesis activity. These results represent that the A. paniculata leaf extract strongly decreases the expression level of the enzyme important for melanin synthesis. Therefore, the A. paniculata extract has a high capability of becoming a lightening agent and hyperpigmentation treatment in the pharmaceutical and cosmetic market. Open Science Publishers LLP Inc. 2023-01 Article PeerReviewed application/pdf en http://eprints.utm.my/106254/1/Rabe%27ahAdam2023_MelanpgenesisInhibitionEffectofEthanolicAndrographis.pdf Adam, Rabe’ah and Ramli, Faiqah and Abdul Hamid, Mariani and Mohd. Bohari, Siti Pauliena (2023) Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression. Journal of Applied Pharmaceutical Science, 13 (1). pp. 128-138. ISSN 2231-3354 http://dx.doi.org/10.7324/JAPS.2023.130107 DOI: 10.7324/JAPS.2023.130107
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Adam, Rabe’ah
Ramli, Faiqah
Abdul Hamid, Mariani
Mohd. Bohari, Siti Pauliena
Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
description Andrographis paniculata is a well-known and highly used potential herbal plant for worldwide medicinal use. Plant studies reported that the leaf extract of A. paniculata, which has high antioxidant capacity, has antifungal, antimicrobial, antiprotozoal, antidiabetic, liver enzyme modulation, insecticidal, and toxicity properties. Nevertheless, no report regarding its antimelanogenic activity is available. Hence, this study was carried out to investigate A. paniculata leaf extract potential of the antimelanogenic property. The data shown from this study proved that the A. paniculata leaf extract is responsible for melanin content reduction and decreases the protein expression of tyrosinase (TYR) and microphthalmia-associated transcription factor in B16F1 melanoma cells. This study found that the A. paniculata leaf extract acted powerfully in the synthesis of tyrosinase-related protein-2 inhibition. TYR is a well-known essential enzyme in melanogenesis activity. These results represent that the A. paniculata leaf extract strongly decreases the expression level of the enzyme important for melanin synthesis. Therefore, the A. paniculata extract has a high capability of becoming a lightening agent and hyperpigmentation treatment in the pharmaceutical and cosmetic market.
format Article
author Adam, Rabe’ah
Ramli, Faiqah
Abdul Hamid, Mariani
Mohd. Bohari, Siti Pauliena
author_facet Adam, Rabe’ah
Ramli, Faiqah
Abdul Hamid, Mariani
Mohd. Bohari, Siti Pauliena
author_sort Adam, Rabe’ah
title Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
title_short Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
title_full Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
title_fullStr Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
title_full_unstemmed Melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
title_sort melanogenesis inhibition effect of ethanolic andrographis paniculata leaf extract via suppression of tyrosinase and mitf expression.
publisher Open Science Publishers LLP Inc.
publishDate 2023
url http://eprints.utm.my/106254/1/Rabe%27ahAdam2023_MelanpgenesisInhibitionEffectofEthanolicAndrographis.pdf
http://eprints.utm.my/106254/
http://dx.doi.org/10.7324/JAPS.2023.130107
_version_ 1802977248545865728
score 13.211869

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