Staff View: Can metagenomics unravel the impact of oral bacteriome in human diseases?

Can metagenomics unravel the impact of oral bacteriome in human diseases?

Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, r...

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Main Authors:	Chattopadhyay, Indranil, Lu, Wenying, Manikam, Rishya, Malarvili, M. B., Ambati, Ranga Rao, Gundamaraju, Rohit
Format:	Article
Published:	Taylor and Francis Ltd. 2023
Subjects:	Q Science (General) QR Microbiology
Online Access:	http://eprints.utm.my/105566/ http://dx.doi.org/10.1080/02648725.2022.2102877
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id	my.utm.105566
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spelling	my.utm.1055662024-05-06T06:25:00Z http://eprints.utm.my/105566/ Can metagenomics unravel the impact of oral bacteriome in human diseases? Chattopadhyay, Indranil Lu, Wenying Manikam, Rishya Malarvili, M. B. Ambati, Ranga Rao Gundamaraju, Rohit Q Science (General) QR Microbiology Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, rheumatoid arthritis, adverse pregnancy outcomes, diabetes, lung infection, colorectal cancer, and pancreatic cancer. Buccal mucosa, tongue dorsum, hard palate, saliva, palatine tonsils, throat, keratinized gingiva, supra-gingival plaque, subgingival plaque, dentures, and lips are microbial habitats of the oral cavity. Porphyromonas gingivalis may have a role in the development of periodontal diseases, oral cancer, diabetes, and atherosclerotic disease. Fusobacterium nucleatum showed a higher abundance in periodontal diseases, oral and colon cancer, adverse pregnancy outcomes, diabetes, and rheumatoid arthritis. The higher abundance of Prevotella intermedia is typical in periodontal diseases, rheumatoid arthritis, and adverse pregnancy outcome. S. salivarius displayed higher abundance in both dental caries and OSCC. Oral bacteria may influence systemic diseases through inflammation by releasing pro inflammatory cytokines. Identification of oral bacteria using culture-dependent approaches and next-generation sequencing-based metagenomic approaches is believed to significantly identify the therapeutic targets and non-invasive diagnostic indicators in different human diseases. Oral bacteria in saliva could be exploited as a non-invasive diagnostic indicator for the early detection of oral and systemic disorders. Other therapeutic approaches such as the use of probiotics, green tea polyphenol, cold atmospheric plasma (CAP) therapy, antimicrobial photodynamic therapy, and antimicrobial peptides are used to inhibit the growth of biofilm formation by oral bacteria. Taylor and Francis Ltd. 2023 Article PeerReviewed Chattopadhyay, Indranil and Lu, Wenying and Manikam, Rishya and Malarvili, M. B. and Ambati, Ranga Rao and Gundamaraju, Rohit (2023) Can metagenomics unravel the impact of oral bacteriome in human diseases? Biotechnology and Genetic Engineering Reviews, 39 (1). pp. 85-117. ISSN 0264-8725 http://dx.doi.org/10.1080/02648725.2022.2102877 DOI : 10.1016/j.biortech.2022.128375
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	Q Science (General) QR Microbiology
spellingShingle	Q Science (General) QR Microbiology Chattopadhyay, Indranil Lu, Wenying Manikam, Rishya Malarvili, M. B. Ambati, Ranga Rao Gundamaraju, Rohit Can metagenomics unravel the impact of oral bacteriome in human diseases?
description	Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, rheumatoid arthritis, adverse pregnancy outcomes, diabetes, lung infection, colorectal cancer, and pancreatic cancer. Buccal mucosa, tongue dorsum, hard palate, saliva, palatine tonsils, throat, keratinized gingiva, supra-gingival plaque, subgingival plaque, dentures, and lips are microbial habitats of the oral cavity. Porphyromonas gingivalis may have a role in the development of periodontal diseases, oral cancer, diabetes, and atherosclerotic disease. Fusobacterium nucleatum showed a higher abundance in periodontal diseases, oral and colon cancer, adverse pregnancy outcomes, diabetes, and rheumatoid arthritis. The higher abundance of Prevotella intermedia is typical in periodontal diseases, rheumatoid arthritis, and adverse pregnancy outcome. S. salivarius displayed higher abundance in both dental caries and OSCC. Oral bacteria may influence systemic diseases through inflammation by releasing pro inflammatory cytokines. Identification of oral bacteria using culture-dependent approaches and next-generation sequencing-based metagenomic approaches is believed to significantly identify the therapeutic targets and non-invasive diagnostic indicators in different human diseases. Oral bacteria in saliva could be exploited as a non-invasive diagnostic indicator for the early detection of oral and systemic disorders. Other therapeutic approaches such as the use of probiotics, green tea polyphenol, cold atmospheric plasma (CAP) therapy, antimicrobial photodynamic therapy, and antimicrobial peptides are used to inhibit the growth of biofilm formation by oral bacteria.
format	Article
author	Chattopadhyay, Indranil Lu, Wenying Manikam, Rishya Malarvili, M. B. Ambati, Ranga Rao Gundamaraju, Rohit
author_facet	Chattopadhyay, Indranil Lu, Wenying Manikam, Rishya Malarvili, M. B. Ambati, Ranga Rao Gundamaraju, Rohit
author_sort	Chattopadhyay, Indranil
title	Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_short	Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_full	Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_fullStr	Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_full_unstemmed	Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_sort	can metagenomics unravel the impact of oral bacteriome in human diseases?
publisher	Taylor and Francis Ltd.
publishDate	2023
url	http://eprints.utm.my/105566/ http://dx.doi.org/10.1080/02648725.2022.2102877
_version_	1800082630326091776
score	13.211869

Can metagenomics unravel the impact of oral bacteriome in human diseases?

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