Staff View: Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.

Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.

The use of advanced electroactive catalysts enhances the performance of electrochemical biosensors in real-time biomonitoring and has received much attention owing to its excellent physicochemical and electrochemical possessions. In this work, a novel biosensor was developed based on the electrocata...

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Main Authors:	Duraisamy, Murugesan, Elancheziyan, Mari, Eswaran, Muthusankar, Ganesan, Sivarasan, Ansari, Anees A., Rajamanickam, Govindaraj, Lee, Siew Ling, Tsai, Pei-Chien, Chen, Yi-Hsun, Ponnusamy, Vinoth Kumar
Format:	Article
Published:	Elsevier B.V. 2023
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://eprints.utm.my/105492/ http://dx.doi.org/10.1016/j.ijbiomac.2023.125329
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id	my.utm.105492
record_format	eprints
spelling	my.utm.1054922024-05-05T06:18:04Z http://eprints.utm.my/105492/ Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood. Duraisamy, Murugesan Elancheziyan, Mari Eswaran, Muthusankar Ganesan, Sivarasan Ansari, Anees A. Rajamanickam, Govindaraj Lee, Siew Ling Tsai, Pei-Chien Chen, Yi-Hsun Ponnusamy, Vinoth Kumar Q Science (General) QD Chemistry The use of advanced electroactive catalysts enhances the performance of electrochemical biosensors in real-time biomonitoring and has received much attention owing to its excellent physicochemical and electrochemical possessions. In this work, a novel biosensor was developed based on the electrocatalytic activity of functionalized vanadium carbide (VC) material, including VC@ruthenium (Ru), VC@Ru-polyaniline nanoparticles (VC@Ru-PANI-NPs) as non-enzymatic nanocarriers for the fabrication of modified screen-printed electrode (SPE) to detect acetaminophen in human blood. As-prepared materials were characterized using SEM, TEM, XRD, and XPS techniques. Biosensing was carried out using cyclic voltammetry and differential pulse voltammetry techniques and has revealed imperative electrocatalytic activity. A quasi-reversible redox method of the over-potential of acetaminophen increased considerably compared with that at the modified electrode and the bare SPE. The excellent electrocatalytic behaviour of VC@Ru-PANI-NPs/SPE is attributed to its distinctive chemical and physical properties, including rapid electron transfer, striking ᴫ-ᴫ interface, and strong adsorptive capability. This electrochemical biosensor exhibits a detection limit of 0.024 μM, in a linear range of 0.1–382.72 μM with a reproducibility of 2.45 % relative standard deviation, and a good recovery from 96.69 % to 105.59 %, the acquired results ensure a better performance compared with previous reports. The enriched electrocatalytic activity of this developed biosensor is mainly credited to its high surface area, better electrical conductivity, synergistic effect, and abundant electroactive sites. The real-world utility of the VC@Ru-PANI-NPs/SPE-based sensor was ensured via the investigation of biomonitoring of acetaminophen in human blood samples with satisfactory recoveries. Elsevier B.V. 2023-07-31 Article PeerReviewed Duraisamy, Murugesan and Elancheziyan, Mari and Eswaran, Muthusankar and Ganesan, Sivarasan and Ansari, Anees A. and Rajamanickam, Govindaraj and Lee, Siew Ling and Tsai, Pei-Chien and Chen, Yi-Hsun and Ponnusamy, Vinoth Kumar (2023) Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood. International Journal of Biological Macromolecules, 244 (125329). NA-NA. ISSN 0141-8130 http://dx.doi.org/10.1016/j.ijbiomac.2023.125329 DOI: 10.1016/j.ijbiomac.2023.125329
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Duraisamy, Murugesan Elancheziyan, Mari Eswaran, Muthusankar Ganesan, Sivarasan Ansari, Anees A. Rajamanickam, Govindaraj Lee, Siew Ling Tsai, Pei-Chien Chen, Yi-Hsun Ponnusamy, Vinoth Kumar Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
description	The use of advanced electroactive catalysts enhances the performance of electrochemical biosensors in real-time biomonitoring and has received much attention owing to its excellent physicochemical and electrochemical possessions. In this work, a novel biosensor was developed based on the electrocatalytic activity of functionalized vanadium carbide (VC) material, including VC@ruthenium (Ru), VC@Ru-polyaniline nanoparticles (VC@Ru-PANI-NPs) as non-enzymatic nanocarriers for the fabrication of modified screen-printed electrode (SPE) to detect acetaminophen in human blood. As-prepared materials were characterized using SEM, TEM, XRD, and XPS techniques. Biosensing was carried out using cyclic voltammetry and differential pulse voltammetry techniques and has revealed imperative electrocatalytic activity. A quasi-reversible redox method of the over-potential of acetaminophen increased considerably compared with that at the modified electrode and the bare SPE. The excellent electrocatalytic behaviour of VC@Ru-PANI-NPs/SPE is attributed to its distinctive chemical and physical properties, including rapid electron transfer, striking ᴫ-ᴫ interface, and strong adsorptive capability. This electrochemical biosensor exhibits a detection limit of 0.024 μM, in a linear range of 0.1–382.72 μM with a reproducibility of 2.45 % relative standard deviation, and a good recovery from 96.69 % to 105.59 %, the acquired results ensure a better performance compared with previous reports. The enriched electrocatalytic activity of this developed biosensor is mainly credited to its high surface area, better electrical conductivity, synergistic effect, and abundant electroactive sites. The real-world utility of the VC@Ru-PANI-NPs/SPE-based sensor was ensured via the investigation of biomonitoring of acetaminophen in human blood samples with satisfactory recoveries.
format	Article
author	Duraisamy, Murugesan Elancheziyan, Mari Eswaran, Muthusankar Ganesan, Sivarasan Ansari, Anees A. Rajamanickam, Govindaraj Lee, Siew Ling Tsai, Pei-Chien Chen, Yi-Hsun Ponnusamy, Vinoth Kumar
author_facet	Duraisamy, Murugesan Elancheziyan, Mari Eswaran, Muthusankar Ganesan, Sivarasan Ansari, Anees A. Rajamanickam, Govindaraj Lee, Siew Ling Tsai, Pei-Chien Chen, Yi-Hsun Ponnusamy, Vinoth Kumar
author_sort	Duraisamy, Murugesan
title	Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
title_short	Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
title_full	Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
title_fullStr	Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
title_full_unstemmed	Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
title_sort	novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.
publisher	Elsevier B.V.
publishDate	2023
url	http://eprints.utm.my/105492/ http://dx.doi.org/10.1016/j.ijbiomac.2023.125329
_version_	1800082623584796672
score	13.211869

Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood.

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