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Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis

The ability of silica aerogel nanoparticles (SA-Np) to improve the stability of hydroxyapatite (HA) was investigated. Using the sol-gel method, the HA was incorporated into SA-Np at a weight ratio of 0.5 of HA to SiO2 (HA-SA-Np). The efficacy of HA-SA-Np, SA-Np, and HA on the in vitro migration of n...

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Main Authors: Sani, Nor Suriani, Nik Malek, Nik Ahmad Nizam
Format: Article
Language:English
Published: AMG Transcend Association 2023
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/105486/1/NikAhmadNizam2023_HydroxyapatiteModifiedSilicaAerogelNanoparticles.pdf
http://eprints.utm.my/105486/
http://dx.doi.org/10.33263/BRIAC134.373
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spelling my.utm.1054862024-04-30T07:59:50Z http://eprints.utm.my/105486/ Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis Sani, Nor Suriani Nik Malek, Nik Ahmad Nizam QD Chemistry The ability of silica aerogel nanoparticles (SA-Np) to improve the stability of hydroxyapatite (HA) was investigated. Using the sol-gel method, the HA was incorporated into SA-Np at a weight ratio of 0.5 of HA to SiO2 (HA-SA-Np). The efficacy of HA-SA-Np, SA-Np, and HA on the in vitro migration of normal human dermal fibroblast cells (HSF1184) was compared. The cell migration was measured at 0, 6, and 24 hours after scratching using ImageJ and an inverted optical microscope. To ascertain the resorbability of HA-SA-Np, the phosphate and silicic acid concentrations in media treated for 2, 5, and 7 days were examined. The high dissolution of HA could be reduced by incorporating the HA into the silica nanosphere. The HA-SA-Np significantly stimulated cell migration and increased closure with increasing treatment time. It was caused by the release of silicic acid, which aided in healing cells. It also demonstrates the ability of HA-SA-Np to be resorbed and eventually increase the adhesion and migration of normal human fibroblast cells. As a result, the potential application of HA-SA-Np as an alternative biomaterial was confirmed. AMG Transcend Association 2023 Article PeerReviewed application/pdf en http://eprints.utm.my/105486/1/NikAhmadNizam2023_HydroxyapatiteModifiedSilicaAerogelNanoparticles.pdf Sani, Nor Suriani and Nik Malek, Nik Ahmad Nizam (2023) Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis. Biointerface Research in Applied Chemistry, 13 (4). pp. 1-10. ISSN 2069-5837 http://dx.doi.org/10.33263/BRIAC134.373 DOI : 10.33263/BRIAC134.373
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Sani, Nor Suriani
Nik Malek, Nik Ahmad Nizam
Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
description The ability of silica aerogel nanoparticles (SA-Np) to improve the stability of hydroxyapatite (HA) was investigated. Using the sol-gel method, the HA was incorporated into SA-Np at a weight ratio of 0.5 of HA to SiO2 (HA-SA-Np). The efficacy of HA-SA-Np, SA-Np, and HA on the in vitro migration of normal human dermal fibroblast cells (HSF1184) was compared. The cell migration was measured at 0, 6, and 24 hours after scratching using ImageJ and an inverted optical microscope. To ascertain the resorbability of HA-SA-Np, the phosphate and silicic acid concentrations in media treated for 2, 5, and 7 days were examined. The high dissolution of HA could be reduced by incorporating the HA into the silica nanosphere. The HA-SA-Np significantly stimulated cell migration and increased closure with increasing treatment time. It was caused by the release of silicic acid, which aided in healing cells. It also demonstrates the ability of HA-SA-Np to be resorbed and eventually increase the adhesion and migration of normal human fibroblast cells. As a result, the potential application of HA-SA-Np as an alternative biomaterial was confirmed.
format Article
author Sani, Nor Suriani
Nik Malek, Nik Ahmad Nizam
author_facet Sani, Nor Suriani
Nik Malek, Nik Ahmad Nizam
author_sort Sani, Nor Suriani
title Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
title_short Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
title_full Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
title_fullStr Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
title_full_unstemmed Hydroxyapatite modified silica aerogel nanoparticles: In vitro cell migration analysis
title_sort hydroxyapatite modified silica aerogel nanoparticles: in vitro cell migration analysis
publisher AMG Transcend Association
publishDate 2023
url http://eprints.utm.my/105486/1/NikAhmadNizam2023_HydroxyapatiteModifiedSilicaAerogelNanoparticles.pdf
http://eprints.utm.my/105486/
http://dx.doi.org/10.33263/BRIAC134.373
_version_ 1797906032321626112
score 13.211869

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