Staff View: An overview of the anti-HIV potential of thiazolidinone derivatives

An overview of the anti-HIV potential of thiazolidinone derivatives

Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS), an immunosuppressive, life-threatening condition that frequently results in other potentially fatal opportunistic infections in affected patients. Despite advancements in anti-retro-viral therapy, AIDS rema...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mohamed A. Abid, Fatma, Salim, Nurul Syahirah, Abdul Wahab, Roswanira, Hashim, Siti Ernieyanti, Sankaranarayanan, Murugesan, Bhat, Ajmal, Jamalis, Joazaizulfazli
Format:	Article
Published:	Bentham Science Publishers 2023
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/105027/ http://dx.doi.org/10.2174/2211352521666230718094413
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.utm.105027
record_format	eprints
spelling	my.utm.1050272024-04-01T07:52:04Z http://eprints.utm.my/105027/ An overview of the anti-HIV potential of thiazolidinone derivatives Mohamed A. Abid, Fatma Salim, Nurul Syahirah Abdul Wahab, Roswanira Hashim, Siti Ernieyanti Sankaranarayanan, Murugesan Bhat, Ajmal Jamalis, Joazaizulfazli QD Chemistry Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS), an immunosuppressive, life-threatening condition that frequently results in other potentially fatal opportunistic infections in affected patients. Despite advancements in anti-retro-viral therapy, AIDS remains the main reason for worldwide mortality. Although various anti-HIV drugs have profoundly enhanced the quality of life for AIDS patients, some patients develop resistance to the drugs, and the long-term anti-HIV treatments, and their adverse effects, prevail as major therapeutic failure causes. Therefore, concerted efforts by the scientific community are cru-cial to identifying new candidates for anti-HIV therapies. In this respect, the thiazolidinone moiety has acquired prominence in drug discovery and development due to its antifungal, antiviral, anti-depressant, anticancer, and antibacterial properties. This moiety also demonstrated significant anti-HIV activity as a core heterocycle or derivative of substituted heterocycles. To expedite the synthesis of more novel anti-HIV drugs containing a thiazolidinone nucleus, we compiled a list of thiazolidinone-containing previously documented anti-HIV compounds. We hope that this could serve as a guide for future researchers in their design of effective thiazolidine-containing compounds showing anti-HIV activity. Bentham Science Publishers 2023 Article PeerReviewed Mohamed A. Abid, Fatma and Salim, Nurul Syahirah and Abdul Wahab, Roswanira and Hashim, Siti Ernieyanti and Sankaranarayanan, Murugesan and Bhat, Ajmal and Jamalis, Joazaizulfazli (2023) An overview of the anti-HIV potential of thiazolidinone derivatives. Anti-Infective Agents, 21 (5). pp. 40-59. ISSN 2211-3525 http://dx.doi.org/10.2174/2211352521666230718094413 DOI : 10.2174/2211352521666230718094413
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QD Chemistry
spellingShingle	QD Chemistry Mohamed A. Abid, Fatma Salim, Nurul Syahirah Abdul Wahab, Roswanira Hashim, Siti Ernieyanti Sankaranarayanan, Murugesan Bhat, Ajmal Jamalis, Joazaizulfazli An overview of the anti-HIV potential of thiazolidinone derivatives
description	Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS), an immunosuppressive, life-threatening condition that frequently results in other potentially fatal opportunistic infections in affected patients. Despite advancements in anti-retro-viral therapy, AIDS remains the main reason for worldwide mortality. Although various anti-HIV drugs have profoundly enhanced the quality of life for AIDS patients, some patients develop resistance to the drugs, and the long-term anti-HIV treatments, and their adverse effects, prevail as major therapeutic failure causes. Therefore, concerted efforts by the scientific community are cru-cial to identifying new candidates for anti-HIV therapies. In this respect, the thiazolidinone moiety has acquired prominence in drug discovery and development due to its antifungal, antiviral, anti-depressant, anticancer, and antibacterial properties. This moiety also demonstrated significant anti-HIV activity as a core heterocycle or derivative of substituted heterocycles. To expedite the synthesis of more novel anti-HIV drugs containing a thiazolidinone nucleus, we compiled a list of thiazolidinone-containing previously documented anti-HIV compounds. We hope that this could serve as a guide for future researchers in their design of effective thiazolidine-containing compounds showing anti-HIV activity.
format	Article
author	Mohamed A. Abid, Fatma Salim, Nurul Syahirah Abdul Wahab, Roswanira Hashim, Siti Ernieyanti Sankaranarayanan, Murugesan Bhat, Ajmal Jamalis, Joazaizulfazli
author_facet	Mohamed A. Abid, Fatma Salim, Nurul Syahirah Abdul Wahab, Roswanira Hashim, Siti Ernieyanti Sankaranarayanan, Murugesan Bhat, Ajmal Jamalis, Joazaizulfazli
author_sort	Mohamed A. Abid, Fatma
title	An overview of the anti-HIV potential of thiazolidinone derivatives
title_short	An overview of the anti-HIV potential of thiazolidinone derivatives
title_full	An overview of the anti-HIV potential of thiazolidinone derivatives
title_fullStr	An overview of the anti-HIV potential of thiazolidinone derivatives
title_full_unstemmed	An overview of the anti-HIV potential of thiazolidinone derivatives
title_sort	overview of the anti-hiv potential of thiazolidinone derivatives
publisher	Bentham Science Publishers
publishDate	2023
url	http://eprints.utm.my/105027/ http://dx.doi.org/10.2174/2211352521666230718094413
_version_	1797905912220876800
score	13.211869

An overview of the anti-HIV potential of thiazolidinone derivatives

Similar Items