Staff View: Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study

Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study

The dynamic characteristic of bone is its ability to remodel itself through mechanobiological responses. Bone regeneration is triggered by mechanical cues from physiological activities that generate structural strain and cause bone marrow movement. This phenomenon is crucial for bone scaffold when i...

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Main Authors:	Noordin, Muhammad Azfar, Kori, Mohamad Ikhwan, Abdul Wahab, Abdul Hadi, Syahrom, Ardiyansyah, Md. Saad, Amir Putra
Format:	Article
Published:	Springer Nature 2022
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.utm.my/104661/ http://dx.doi.org/10.1007/s11242-022-01849-6
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spelling	my.utm.1046612024-02-21T08:54:54Z http://eprints.utm.my/104661/ Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study Noordin, Muhammad Azfar Kori, Mohamad Ikhwan Abdul Wahab, Abdul Hadi Syahrom, Ardiyansyah Md. Saad, Amir Putra TJ Mechanical engineering and machinery The dynamic characteristic of bone is its ability to remodel itself through mechanobiological responses. Bone regeneration is triggered by mechanical cues from physiological activities that generate structural strain and cause bone marrow movement. This phenomenon is crucial for bone scaffold when implanted in the cancellous bone as host tissue. Often, the fluid movement of bone scaffold and cancellous bone is studied separately, which does not represent the actual environment once implanted. In the present study, the fluid flow analysis properties of bone scaffold integrated into the cancellous bone at different skeletal sites are investigated. Three types of porous bone scaffolds categorized based on pore size configurations: 1 mm, 0.8 mm and hybrid (0.8 mm interlaced with 0.5 mm) were used. Three different skeletal sites of femoral bone were selected: neck, lateral condyle and medial condyle. Computational fluid dynamics was utilized to analyze the fluid flow properties of bone scaffold integrated cancellous bone. The results of this study reveal that the localization and maximum value of shear stress in an independent bone scaffold are significantly different compared to the bone scaffold integrated with cancellous bone by about 160% to 448% percentage difference. Low shear stress and high permeability were found across models that have higher Tb.Sp (trabecular separation). Specimen C and femoral lateral condyle showed the highest permeability in their respective category. Springer Nature 2022-10 Article PeerReviewed Noordin, Muhammad Azfar and Kori, Mohamad Ikhwan and Abdul Wahab, Abdul Hadi and Syahrom, Ardiyansyah and Md. Saad, Amir Putra (2022) Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study. Transport in Porous Media, 145 (1). pp. 271-290. ISSN 0169-3913 http://dx.doi.org/10.1007/s11242-022-01849-6 DOI:10.1007/s11242-022-01849-6
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Noordin, Muhammad Azfar Kori, Mohamad Ikhwan Abdul Wahab, Abdul Hadi Syahrom, Ardiyansyah Md. Saad, Amir Putra Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
description	The dynamic characteristic of bone is its ability to remodel itself through mechanobiological responses. Bone regeneration is triggered by mechanical cues from physiological activities that generate structural strain and cause bone marrow movement. This phenomenon is crucial for bone scaffold when implanted in the cancellous bone as host tissue. Often, the fluid movement of bone scaffold and cancellous bone is studied separately, which does not represent the actual environment once implanted. In the present study, the fluid flow analysis properties of bone scaffold integrated into the cancellous bone at different skeletal sites are investigated. Three types of porous bone scaffolds categorized based on pore size configurations: 1 mm, 0.8 mm and hybrid (0.8 mm interlaced with 0.5 mm) were used. Three different skeletal sites of femoral bone were selected: neck, lateral condyle and medial condyle. Computational fluid dynamics was utilized to analyze the fluid flow properties of bone scaffold integrated cancellous bone. The results of this study reveal that the localization and maximum value of shear stress in an independent bone scaffold are significantly different compared to the bone scaffold integrated with cancellous bone by about 160% to 448% percentage difference. Low shear stress and high permeability were found across models that have higher Tb.Sp (trabecular separation). Specimen C and femoral lateral condyle showed the highest permeability in their respective category.
format	Article
author	Noordin, Muhammad Azfar Kori, Mohamad Ikhwan Abdul Wahab, Abdul Hadi Syahrom, Ardiyansyah Md. Saad, Amir Putra
author_facet	Noordin, Muhammad Azfar Kori, Mohamad Ikhwan Abdul Wahab, Abdul Hadi Syahrom, Ardiyansyah Md. Saad, Amir Putra
author_sort	Noordin, Muhammad Azfar
title	Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
title_short	Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
title_full	Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
title_fullStr	Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
title_full_unstemmed	Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
title_sort	fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study
publisher	Springer Nature
publishDate	2022
url	http://eprints.utm.my/104661/ http://dx.doi.org/10.1007/s11242-022-01849-6
_version_	1792147933789945856
score	13.211869

Fluid flow analysis of integrated porous bone scaffold and cancellous bone at different skeletal sites: in silico study

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