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Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.

BackgroundFicus deltoidea(Moraceae), is a Malay Traditional Medicine locally known as Mas Cotek. Three varieties (angustifolia, deltoidea andkunslerii) has been indictincty used. AimsWe here aim to better understand their chemistry and bioactivities to inform future scientific and agronomic research...

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Main Authors: Mohd. Hanafi, Mohd. Mukrish, O. Alqahtani, Omaish Salman, Gui, Linna, Ya'Akob, Harisun, M. Prieto, Jose
Format: Article
Language:English
Published: The Library Services of Liverpool 2022
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/104144/1/MohdMukrishMohdHanafiOmaishSalmanOAlqahtani2022_PhytochemicalFingerprintandBiologicalActivities.pdf
http://eprints.utm.my/104144/
http://dx.doi.org/10.24377/jnpd.article668
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spelling my.utm.1041442024-01-17T01:32:26Z http://eprints.utm.my/104144/ Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars. Mohd. Hanafi, Mohd. Mukrish O. Alqahtani, Omaish Salman Gui, Linna Ya'Akob, Harisun M. Prieto, Jose TP Chemical technology BackgroundFicus deltoidea(Moraceae), is a Malay Traditional Medicine locally known as Mas Cotek. Three varieties (angustifolia, deltoidea andkunslerii) has been indictincty used. AimsWe here aim to better understand their chemistry and bioactivities to inform future scientific and agronomic research.MethodsWe extracted and analyzed (HPTLCand HPLC-UV)samples from these varieties. The in vitroscreening includedthe scavenging ofDPPH and NO radicals, activity upon tyrosinase and cytotoxicity against three human prostate cancer cells (PC3, DU145 and LNCaP)using the sulforhodamine B proliferation assay and the MTT mitochondrial viability assay.ResultsWe showthat vitexin, orientin and isoorientin may act as intraspecific and interorgan phytomarkers The biological activities of the extracts point out to the antioxidant value of extracts from the deltoideaand kunsleriivarieties whilst the inhibition of tyrosinase is only present in the rootsextract of the var. deltoidea which is also endowed with cytotoxic activity against prostate cancer cells.ConclusionWe suggest that the three Malaysian Ficus deltoideabotanical varieties (angustifolia, deltoideaand kunslerii) can be considered chemovars. The most active extract was from the roots of var. deltoideathat showsantioxidant, antimelanogenic and cytotoxic potential. The Library Services of Liverpool 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/104144/1/MohdMukrishMohdHanafiOmaishSalmanOAlqahtani2022_PhytochemicalFingerprintandBiologicalActivities.pdf Mohd. Hanafi, Mohd. Mukrish and O. Alqahtani, Omaish Salman and Gui, Linna and Ya'Akob, Harisun and M. Prieto, Jose (2022) Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars. Journal Of Natural Products Discovery, 1 (2). pp. 3-12. ISSN 2755-1997 http://dx.doi.org/10.24377/jnpd.article668 DOI: 10.24377/jnpd.article668
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Mohd. Hanafi, Mohd. Mukrish
O. Alqahtani, Omaish Salman
Gui, Linna
Ya'Akob, Harisun
M. Prieto, Jose
Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
description BackgroundFicus deltoidea(Moraceae), is a Malay Traditional Medicine locally known as Mas Cotek. Three varieties (angustifolia, deltoidea andkunslerii) has been indictincty used. AimsWe here aim to better understand their chemistry and bioactivities to inform future scientific and agronomic research.MethodsWe extracted and analyzed (HPTLCand HPLC-UV)samples from these varieties. The in vitroscreening includedthe scavenging ofDPPH and NO radicals, activity upon tyrosinase and cytotoxicity against three human prostate cancer cells (PC3, DU145 and LNCaP)using the sulforhodamine B proliferation assay and the MTT mitochondrial viability assay.ResultsWe showthat vitexin, orientin and isoorientin may act as intraspecific and interorgan phytomarkers The biological activities of the extracts point out to the antioxidant value of extracts from the deltoideaand kunsleriivarieties whilst the inhibition of tyrosinase is only present in the rootsextract of the var. deltoidea which is also endowed with cytotoxic activity against prostate cancer cells.ConclusionWe suggest that the three Malaysian Ficus deltoideabotanical varieties (angustifolia, deltoideaand kunslerii) can be considered chemovars. The most active extract was from the roots of var. deltoideathat showsantioxidant, antimelanogenic and cytotoxic potential.
format Article
author Mohd. Hanafi, Mohd. Mukrish
O. Alqahtani, Omaish Salman
Gui, Linna
Ya'Akob, Harisun
M. Prieto, Jose
author_facet Mohd. Hanafi, Mohd. Mukrish
O. Alqahtani, Omaish Salman
Gui, Linna
Ya'Akob, Harisun
M. Prieto, Jose
author_sort Mohd. Hanafi, Mohd. Mukrish
title Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
title_short Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
title_full Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
title_fullStr Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
title_full_unstemmed Phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
title_sort phytochemical fingerprint and biological activities of three malaysian ficusdeltoidea cultivars.
publisher The Library Services of Liverpool
publishDate 2022
url http://eprints.utm.my/104144/1/MohdMukrishMohdHanafiOmaishSalmanOAlqahtani2022_PhytochemicalFingerprintandBiologicalActivities.pdf
http://eprints.utm.my/104144/
http://dx.doi.org/10.24377/jnpd.article668
_version_ 1789424385401028608
score 13.222552

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