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CFD simulation on permeability of porous scaffolds forhuman skeletal system

Human skeletal system provides the protection of all organs and supports the loads from various daily activities. Therefore, the main objective of bone scaffold is to have mechanical strength to support the load and have the permeability that will have mass fluid transfer to enhance the healing of d...

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Main Authors: Jusoh, Norhana, Azri, Amirul, Amir Hussein, Muhammad Husaini, Khair, Azizul Hakim, Abdul Samad, Adlisa, Aminnudin, Tariq Muhammad, Amsan, Azureen Naja, Abd. Shukor, Muhammad Syahmi Hafizi, Mohd. Noor, Auni Nurhaziqah
Format: Article
Language:English
Published: Penerbit UTM Press 2022
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T Technology (General)
Online Access:http://eprints.utm.my/104067/1/NorhanaJusohAmirulAzriAzizulHakimKhair2022_CFDSimulationonPermeabilityofPorousScaffolds.pdf
http://eprints.utm.my/104067/
http://dx.doi.org/10.11113/humentech.v1n1.11
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spelling my.utm.1040672024-01-14T01:01:24Z http://eprints.utm.my/104067/ CFD simulation on permeability of porous scaffolds forhuman skeletal system Jusoh, Norhana Azri, Amirul Amir Hussein, Muhammad Husaini Khair, Azizul Hakim Abdul Samad, Adlisa Aminnudin, Tariq Muhammad Amsan, Azureen Naja Abd. Shukor, Muhammad Syahmi Hafizi Mohd. Noor, Auni Nurhaziqah T Technology (General) Human skeletal system provides the protection of all organs and supports the loads from various daily activities. Therefore, the main objective of bone scaffold is to have mechanical strength to support the load and have the permeability that will have mass fluid transfer to enhance the healing of defects. In this study, we simulated the permeability of hexagonal unit cells at different pore sizes (1.0 mm, 1.5 mm and 2.0 mm) and at different inlet velocities (0.001 mm/s, 0.5 mm/s and 1 mm/s) by using Computational Fluid Dynamic (CFD) in Ansys software. Our finding shows that pressure drop from inlet to the outlet of the unit cell’s pore increased corresponding to the decreasing of pores diameter. In contrast, increasing the velocities has increased the pressure drop from inlet to the outlet. The pressure drop at 0.001 mm/s, 0.5 mm/s and 1mm/s inlet velocities were 1.40×10-4 Pa, 7.02×10-2 Pa and 1.41×10-1 Pa, respectively for 1.0 mm pore size. The gradual decreased of the pressure will give the cell and nutrient to be diffused to the inner part of the scaffold. We calculated the permeability for each unit cell, and it can be acceptable based on the upper limit of human bone permeability. The variation in velocities did not gave significant differences for the scaffold permeability. However, the different of pore sizes gave significant effect in the scaffold permeability. The permeability value at 0.001 mm/s for 1.0 mm, 1.5 mm and 2.0 mm pore size were 2.900×10-8 m2, 4.863×10-8 m2 and 8.529×10-8 m2, respectively. By taking into accounts the pressure drop and permeability value, unit cell with 1 mm pore size is predicted to show a better performance in promoting cell growth due to the better flow characteristics in the scaffold. Permeability prediction will help in producing a functional bone scaffold that crucial in bone regeneration of the human skeletal system. Penerbit UTM Press 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/104067/1/NorhanaJusohAmirulAzriAzizulHakimKhair2022_CFDSimulationonPermeabilityofPorousScaffolds.pdf Jusoh, Norhana and Azri, Amirul and Amir Hussein, Muhammad Husaini and Khair, Azizul Hakim and Abdul Samad, Adlisa and Aminnudin, Tariq Muhammad and Amsan, Azureen Naja and Abd. Shukor, Muhammad Syahmi Hafizi and Mohd. Noor, Auni Nurhaziqah (2022) CFD simulation on permeability of porous scaffolds forhuman skeletal system. Journal of Human Centered Technology, 1 (2). pp. 39-47. ISSN 2821-3467 http://dx.doi.org/10.11113/humentech.v1n1.11 DOI:10.11113/humentech.v1n1.11
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Jusoh, Norhana
Azri, Amirul
Amir Hussein, Muhammad Husaini
Khair, Azizul Hakim
Abdul Samad, Adlisa
Aminnudin, Tariq Muhammad
Amsan, Azureen Naja
Abd. Shukor, Muhammad Syahmi Hafizi
Mohd. Noor, Auni Nurhaziqah
CFD simulation on permeability of porous scaffolds forhuman skeletal system
description Human skeletal system provides the protection of all organs and supports the loads from various daily activities. Therefore, the main objective of bone scaffold is to have mechanical strength to support the load and have the permeability that will have mass fluid transfer to enhance the healing of defects. In this study, we simulated the permeability of hexagonal unit cells at different pore sizes (1.0 mm, 1.5 mm and 2.0 mm) and at different inlet velocities (0.001 mm/s, 0.5 mm/s and 1 mm/s) by using Computational Fluid Dynamic (CFD) in Ansys software. Our finding shows that pressure drop from inlet to the outlet of the unit cell’s pore increased corresponding to the decreasing of pores diameter. In contrast, increasing the velocities has increased the pressure drop from inlet to the outlet. The pressure drop at 0.001 mm/s, 0.5 mm/s and 1mm/s inlet velocities were 1.40×10-4 Pa, 7.02×10-2 Pa and 1.41×10-1 Pa, respectively for 1.0 mm pore size. The gradual decreased of the pressure will give the cell and nutrient to be diffused to the inner part of the scaffold. We calculated the permeability for each unit cell, and it can be acceptable based on the upper limit of human bone permeability. The variation in velocities did not gave significant differences for the scaffold permeability. However, the different of pore sizes gave significant effect in the scaffold permeability. The permeability value at 0.001 mm/s for 1.0 mm, 1.5 mm and 2.0 mm pore size were 2.900×10-8 m2, 4.863×10-8 m2 and 8.529×10-8 m2, respectively. By taking into accounts the pressure drop and permeability value, unit cell with 1 mm pore size is predicted to show a better performance in promoting cell growth due to the better flow characteristics in the scaffold. Permeability prediction will help in producing a functional bone scaffold that crucial in bone regeneration of the human skeletal system.
format Article
author Jusoh, Norhana
Azri, Amirul
Amir Hussein, Muhammad Husaini
Khair, Azizul Hakim
Abdul Samad, Adlisa
Aminnudin, Tariq Muhammad
Amsan, Azureen Naja
Abd. Shukor, Muhammad Syahmi Hafizi
Mohd. Noor, Auni Nurhaziqah
author_facet Jusoh, Norhana
Azri, Amirul
Amir Hussein, Muhammad Husaini
Khair, Azizul Hakim
Abdul Samad, Adlisa
Aminnudin, Tariq Muhammad
Amsan, Azureen Naja
Abd. Shukor, Muhammad Syahmi Hafizi
Mohd. Noor, Auni Nurhaziqah
author_sort Jusoh, Norhana
title CFD simulation on permeability of porous scaffolds forhuman skeletal system
title_short CFD simulation on permeability of porous scaffolds forhuman skeletal system
title_full CFD simulation on permeability of porous scaffolds forhuman skeletal system
title_fullStr CFD simulation on permeability of porous scaffolds forhuman skeletal system
title_full_unstemmed CFD simulation on permeability of porous scaffolds forhuman skeletal system
title_sort cfd simulation on permeability of porous scaffolds forhuman skeletal system
publisher Penerbit UTM Press
publishDate 2022
url http://eprints.utm.my/104067/1/NorhanaJusohAmirulAzriAzizulHakimKhair2022_CFDSimulationonPermeabilityofPorousScaffolds.pdf
http://eprints.utm.my/104067/
http://dx.doi.org/10.11113/humentech.v1n1.11
_version_ 1789424373336113152
score 13.211869

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