Staff View: Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students

Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students

Background: The human transcriptome across a variety of cell types and tissues are affected by stress and other psychological factors. Preksha Dhyāna meditation (PM) is effective at improving cognitive skills in novice healthy college student meditators after 8 weeks of intervention, but the molecul...

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Main Authors:	Abomoelak, Bassam, Pragya, Samani U., Griswold, Anthony J., Mehta, Neelam, Uddin, Parvin, Veeramachaneni, Pushya, Mehta, Naina, Pragya, Samani C., El Enshasy, Hesham Ali, Mehta, Devendra
Format:	Article
Language:	English
Published:	Elsevier B.V. 2022
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/103955/1/HeshamAli2022_PrekshaDhyanaMeditationInducesAlterations.pdf http://eprints.utm.my/103955/ http://dx.doi.org/10.1016/j.sjbs.2021.11.060
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id	my.utm.103955
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spelling	my.utm.1039552023-12-10T04:42:11Z http://eprints.utm.my/103955/ Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students Abomoelak, Bassam Pragya, Samani U. Griswold, Anthony J. Mehta, Neelam Uddin, Parvin Veeramachaneni, Pushya Mehta, Naina Pragya, Samani C. El Enshasy, Hesham Ali Mehta, Devendra Q Science (General) Background: The human transcriptome across a variety of cell types and tissues are affected by stress and other psychological factors. Preksha Dhyāna meditation (PM) is effective at improving cognitive skills in novice healthy college student meditators after 8 weeks of intervention, but the molecular and cellular mechanisms involved in these improvements are still largely unknown. Methods: In order to decipher potential mechanisms at the cellular level, transcriptomic profiling analyses, from peripheral blood, were performed at baseline and 8 weeks post-intervention in 18-paired participants (RNASeq). Results: At the transcriptomic level, 494 genes were nominally differentially expressed (p-value ≤ 0.05) between baseline and 8 weeks post-intervention. Our data showed that 136 genes were upregulated, while 358 genes were downregulated. These genes were enriched in several cellular pathways including innate and adaptive immunity, cell signaling, and other metabolic processes. Conclusions: Overall, our findings indicate that PM meditation affects gene expression patterns from whole blood in novice healthy college students. Improvements at the cognitive skills were also mirrored with changes at RNA expression profiling. Elsevier B.V. 2022-04 Article PeerReviewed application/pdf en http://eprints.utm.my/103955/1/HeshamAli2022_PrekshaDhyanaMeditationInducesAlterations.pdf Abomoelak, Bassam and Pragya, Samani U. and Griswold, Anthony J. and Mehta, Neelam and Uddin, Parvin and Veeramachaneni, Pushya and Mehta, Naina and Pragya, Samani C. and El Enshasy, Hesham Ali and Mehta, Devendra (2022) Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students. Saudi Journal of Biological Sciences, 29 (4). pp. 2299-2305. ISSN 1319-562X http://dx.doi.org/10.1016/j.sjbs.2021.11.060 DOI:10.1016/j.sjbs.2021.11.060
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Abomoelak, Bassam Pragya, Samani U. Griswold, Anthony J. Mehta, Neelam Uddin, Parvin Veeramachaneni, Pushya Mehta, Naina Pragya, Samani C. El Enshasy, Hesham Ali Mehta, Devendra Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
description	Background: The human transcriptome across a variety of cell types and tissues are affected by stress and other psychological factors. Preksha Dhyāna meditation (PM) is effective at improving cognitive skills in novice healthy college student meditators after 8 weeks of intervention, but the molecular and cellular mechanisms involved in these improvements are still largely unknown. Methods: In order to decipher potential mechanisms at the cellular level, transcriptomic profiling analyses, from peripheral blood, were performed at baseline and 8 weeks post-intervention in 18-paired participants (RNASeq). Results: At the transcriptomic level, 494 genes were nominally differentially expressed (p-value ≤ 0.05) between baseline and 8 weeks post-intervention. Our data showed that 136 genes were upregulated, while 358 genes were downregulated. These genes were enriched in several cellular pathways including innate and adaptive immunity, cell signaling, and other metabolic processes. Conclusions: Overall, our findings indicate that PM meditation affects gene expression patterns from whole blood in novice healthy college students. Improvements at the cognitive skills were also mirrored with changes at RNA expression profiling.
format	Article
author	Abomoelak, Bassam Pragya, Samani U. Griswold, Anthony J. Mehta, Neelam Uddin, Parvin Veeramachaneni, Pushya Mehta, Naina Pragya, Samani C. El Enshasy, Hesham Ali Mehta, Devendra
author_facet	Abomoelak, Bassam Pragya, Samani U. Griswold, Anthony J. Mehta, Neelam Uddin, Parvin Veeramachaneni, Pushya Mehta, Naina Pragya, Samani C. El Enshasy, Hesham Ali Mehta, Devendra
author_sort	Abomoelak, Bassam
title	Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
title_short	Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
title_full	Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
title_fullStr	Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
title_full_unstemmed	Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
title_sort	preksha dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students
publisher	Elsevier B.V.
publishDate	2022
url	http://eprints.utm.my/103955/1/HeshamAli2022_PrekshaDhyanaMeditationInducesAlterations.pdf http://eprints.utm.my/103955/ http://dx.doi.org/10.1016/j.sjbs.2021.11.060
_version_	1787132164802871296
score	13.211869

Preksha Dhyāna meditation induces alterations at the transcriptome level in novice and healthy college students

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