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Modified irradiation technique for transfusable blood using a clinical linear accelerator

Whole blood irradiation prior to blood transfusion mitigates the risk of Transfusion Associated Graft versus Host Disease (TA-GvHD) to the receiver. This study aimed to improve dose homogeneity, also to benefit from a faster technique and a simplified blood irradiation workflow. An acrylic box accom...

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Main Authors: Wahabi, Janatul Madinah, Abu Hanifah, Noor Zati Hani, Hashim, Suhairul, Bradley, David A.
Format: Article
Published: Elsevier Ltd 2022
Subjects:
QC Physics
Online Access:http://eprints.utm.my/103899/
http://dx.doi.org/10.1016/j.radphyschem.2022.110277
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spelling my.utm.1038992023-12-04T07:51:09Z http://eprints.utm.my/103899/ Modified irradiation technique for transfusable blood using a clinical linear accelerator Wahabi, Janatul Madinah Abu Hanifah, Noor Zati Hani Hashim, Suhairul Bradley, David A. QC Physics Whole blood irradiation prior to blood transfusion mitigates the risk of Transfusion Associated Graft versus Host Disease (TA-GvHD) to the receiver. This study aimed to improve dose homogeneity, also to benefit from a faster technique and a simplified blood irradiation workflow. An acrylic box accommodating eight units of blood has been fabricated, build-up material being used to ensure dose homogeneity. A linear accelerator dose distribution treatment plan for blood bag irradiations has been evaluated, measurement of dose using nanoDot optically stimulated luminescent dosimeters (OSLD) allowing comparison with calculated dose. By using build-up material, dose distribution was within 95%–107% of the prescribed dose. With all eight units of blood accommodated in the box, an irradiation time of 20 min per box has been needed. Compared to a previously adopted procedure, use of the acrylic box and build-up material maintains dose homogeneity, also simplifying the workflow, the technique also being easy to undertake by the operators. Elsevier Ltd 2022-11 Article PeerReviewed Wahabi, Janatul Madinah and Abu Hanifah, Noor Zati Hani and Hashim, Suhairul and Bradley, David A. (2022) Modified irradiation technique for transfusable blood using a clinical linear accelerator. Radiation Physics and Chemistry, 200 (NA). pp. 1-7. ISSN 0969-806X http://dx.doi.org/10.1016/j.radphyschem.2022.110277 DOI:10.1016/j.radphyschem.2022.110277
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QC Physics
spellingShingle QC Physics
Wahabi, Janatul Madinah
Abu Hanifah, Noor Zati Hani
Hashim, Suhairul
Bradley, David A.
Modified irradiation technique for transfusable blood using a clinical linear accelerator
description Whole blood irradiation prior to blood transfusion mitigates the risk of Transfusion Associated Graft versus Host Disease (TA-GvHD) to the receiver. This study aimed to improve dose homogeneity, also to benefit from a faster technique and a simplified blood irradiation workflow. An acrylic box accommodating eight units of blood has been fabricated, build-up material being used to ensure dose homogeneity. A linear accelerator dose distribution treatment plan for blood bag irradiations has been evaluated, measurement of dose using nanoDot optically stimulated luminescent dosimeters (OSLD) allowing comparison with calculated dose. By using build-up material, dose distribution was within 95%–107% of the prescribed dose. With all eight units of blood accommodated in the box, an irradiation time of 20 min per box has been needed. Compared to a previously adopted procedure, use of the acrylic box and build-up material maintains dose homogeneity, also simplifying the workflow, the technique also being easy to undertake by the operators.
format Article
author Wahabi, Janatul Madinah
Abu Hanifah, Noor Zati Hani
Hashim, Suhairul
Bradley, David A.
author_facet Wahabi, Janatul Madinah
Abu Hanifah, Noor Zati Hani
Hashim, Suhairul
Bradley, David A.
author_sort Wahabi, Janatul Madinah
title Modified irradiation technique for transfusable blood using a clinical linear accelerator
title_short Modified irradiation technique for transfusable blood using a clinical linear accelerator
title_full Modified irradiation technique for transfusable blood using a clinical linear accelerator
title_fullStr Modified irradiation technique for transfusable blood using a clinical linear accelerator
title_full_unstemmed Modified irradiation technique for transfusable blood using a clinical linear accelerator
title_sort modified irradiation technique for transfusable blood using a clinical linear accelerator
publisher Elsevier Ltd
publishDate 2022
url http://eprints.utm.my/103899/
http://dx.doi.org/10.1016/j.radphyschem.2022.110277
_version_ 1784511519086608384
score 13.211869

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