Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control

Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. An...

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Main Authors: Edis, Zehra, Bloukh, Samir Haj, Abu Sara, Hamed, Wan Azelee, Nur Izyan
Format: Article
Language:English
Published: MDPI 2022
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Online Access:http://eprints.utm.my/103836/1/NurIzyanWanAzelee2022_AntimicrobialBiomaterialonSuturesBandages.pdf
http://eprints.utm.my/103836/
http://dx.doi.org/10.3390/polym14101932
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spelling my.utm.1038362023-12-01T02:06:11Z http://eprints.utm.my/103836/ Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control Edis, Zehra Bloukh, Samir Haj Abu Sara, Hamed Wan Azelee, Nur Izyan Q Science (General) Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. Antiseptic iodophors and many phytochemicals are unaffected by AMR. Surgical site and wound infections can be prevented or treated by utilizing such compounds on sutures and bandages. Coating surgical face masks with these antimicrobials can reduce microbial infections and attenuate their burden on the environment by re-use. The facile combination of Aloe Vera Barbadensis Miller (AV), Transcinnamic acid (TCA) and Iodine (I2) encapsulated in a polyvinylpyrrolidone (PVP) matrix seems a promising alternative to common antimicrobials. The AV-PVP-TCA-I2 formulation was impregnated into sterile discs, medical gauze bandages, surgical sutures and face masks. Morphology, purity and composition were confirmed by several analytical methods. Antimicrobial activity of AV-PVP-TCA-I2 was investigated by disc diffusion methods against ten microbial strains in comparison to gentamycin and nystatin. AV-PVP-TCA-I2 showed excellent antifungal and strong to intermediate antibacterial activities against most of the selected pathogens, especially in bandages and face masks. The title compound has potential use for prevention or treatment of surgical site and wound infections. Coating disposable face masks with AV-PVP-TCA-I2 may be a sustainable solution for their re-use and waste management. MDPI 2022-05-02 Article PeerReviewed application/pdf en http://eprints.utm.my/103836/1/NurIzyanWanAzelee2022_AntimicrobialBiomaterialonSuturesBandages.pdf Edis, Zehra and Bloukh, Samir Haj and Abu Sara, Hamed and Wan Azelee, Nur Izyan (2022) Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control. Polymers, 14 (10). pp. 1-29. ISSN 2073-4360 http://dx.doi.org/10.3390/polym14101932 DOI:10.3390/polym14101932
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Edis, Zehra
Bloukh, Samir Haj
Abu Sara, Hamed
Wan Azelee, Nur Izyan
Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
description Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. Antiseptic iodophors and many phytochemicals are unaffected by AMR. Surgical site and wound infections can be prevented or treated by utilizing such compounds on sutures and bandages. Coating surgical face masks with these antimicrobials can reduce microbial infections and attenuate their burden on the environment by re-use. The facile combination of Aloe Vera Barbadensis Miller (AV), Transcinnamic acid (TCA) and Iodine (I2) encapsulated in a polyvinylpyrrolidone (PVP) matrix seems a promising alternative to common antimicrobials. The AV-PVP-TCA-I2 formulation was impregnated into sterile discs, medical gauze bandages, surgical sutures and face masks. Morphology, purity and composition were confirmed by several analytical methods. Antimicrobial activity of AV-PVP-TCA-I2 was investigated by disc diffusion methods against ten microbial strains in comparison to gentamycin and nystatin. AV-PVP-TCA-I2 showed excellent antifungal and strong to intermediate antibacterial activities against most of the selected pathogens, especially in bandages and face masks. The title compound has potential use for prevention or treatment of surgical site and wound infections. Coating disposable face masks with AV-PVP-TCA-I2 may be a sustainable solution for their re-use and waste management.
format Article
author Edis, Zehra
Bloukh, Samir Haj
Abu Sara, Hamed
Wan Azelee, Nur Izyan
author_facet Edis, Zehra
Bloukh, Samir Haj
Abu Sara, Hamed
Wan Azelee, Nur Izyan
author_sort Edis, Zehra
title Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
title_short Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
title_full Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
title_fullStr Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
title_full_unstemmed Antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
title_sort antimicrobial biomaterial on sutures, bandages and face masks with potential for infection control
publisher MDPI
publishDate 2022
url http://eprints.utm.my/103836/1/NurIzyanWanAzelee2022_AntimicrobialBiomaterialonSuturesBandages.pdf
http://eprints.utm.my/103836/
http://dx.doi.org/10.3390/polym14101932
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