Staff View: Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer

Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer

Infrared Hyperthermia therapy (IHT) is a non-contacting method to elevate body temperature and treat malignant lesions such as breast cancer. Breast cancer is one of the major cancer types among females and over the years, its prevalence is increasing. Current treatments of breast cancer are surgery...

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Main Authors:	Saim, Hanim, M. Yassin, Siti Norhayati, M. Salim, Maheza I., Jemon, Khairunadwa, H. AlAshwal, Rania, A. Wahab, Asnida, Sahalan, Mariaulpa, Hum, Yan Chai, Lai, K. Wee
Format:	Article
Language:	English
Published:	Springer Science and Business Media B.V. 2022
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/103346/1/MahezaIrnaMohamad2022_AntitumorEffectofInfraredWhole.pdf http://eprints.utm.my/103346/ http://dx.doi.org/10.1007/s11042-022-13521-8
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spelling	my.utm.1033462023-11-01T09:14:57Z http://eprints.utm.my/103346/ Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer Saim, Hanim M. Yassin, Siti Norhayati M. Salim, Maheza I. Jemon, Khairunadwa H. AlAshwal, Rania A. Wahab, Asnida Sahalan, Mariaulpa Hum, Yan Chai Lai, K. Wee Q Science (General) Infrared Hyperthermia therapy (IHT) is a non-contacting method to elevate body temperature and treat malignant lesions such as breast cancer. Breast cancer is one of the major cancer types among females and over the years, its prevalence is increasing. Current treatments of breast cancer are surgery, radiotherapy, chemotherapy and thermotherapy via the use of IHT or combination of these. IHT is most commonly combined with chemotherapy as its effect as a stand alone treatment platform is short lasting. However, chemotherapy induced toxicity to patients. Curcumin has traditionally been used as a food additive or as a remedy in traditional medicine for its anticancer and non-toxic effects. Thus, this research proposed the combination of curcumin and IHT as an alternative to chemotherapy in breast cancer treatment. Mice were inoculated with EMT6 breast cancer cells and assigned to 4 treatment groups: (i) untreated (control), (ii) orally curcumin (CUR), (iii) whole-body hyperthermia (FRWBH), (iv) orally curcumin with whole-body hyperthermia (FRWBH+CUR). Results showed that tumor growth inhibition and body weight gain in the combination treatment group (FRWBH+CUR) are significantly different compared to control. The group also had the longest median survival time (42 days) with no mortality observed during the experiment. This result indicates that the combination treatment is well tolerated by the mice and has negligible levels of toxicity. However, frequent complications of cancer such as anaemia and thrombocytopenia are still observed in the combination treatment group. Platelet to Lymphocyte Ratio (PLR) and Neutrophils to Lymphocytes Ratio (NLR) results indicate that the combination treatment (FRWBH+CUR) has better prognosis outcome than single treatment and may become a potential alternative antitumor treatment of breast cancer. Springer Science and Business Media B.V. 2022-12 Article PeerReviewed application/pdf en http://eprints.utm.my/103346/1/MahezaIrnaMohamad2022_AntitumorEffectofInfraredWhole.pdf Saim, Hanim and M. Yassin, Siti Norhayati and M. Salim, Maheza I. and Jemon, Khairunadwa and H. AlAshwal, Rania and A. Wahab, Asnida and Sahalan, Mariaulpa and Hum, Yan Chai and Lai, K. Wee (2022) Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer. Multimedia Tools and Applications, 81 (29). pp. 41851-41868. ISSN 1380-7501 http://dx.doi.org/10.1007/s11042-022-13521-8 DOI:10.1007/s11042-022-13521-8
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Saim, Hanim M. Yassin, Siti Norhayati M. Salim, Maheza I. Jemon, Khairunadwa H. AlAshwal, Rania A. Wahab, Asnida Sahalan, Mariaulpa Hum, Yan Chai Lai, K. Wee Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
description	Infrared Hyperthermia therapy (IHT) is a non-contacting method to elevate body temperature and treat malignant lesions such as breast cancer. Breast cancer is one of the major cancer types among females and over the years, its prevalence is increasing. Current treatments of breast cancer are surgery, radiotherapy, chemotherapy and thermotherapy via the use of IHT or combination of these. IHT is most commonly combined with chemotherapy as its effect as a stand alone treatment platform is short lasting. However, chemotherapy induced toxicity to patients. Curcumin has traditionally been used as a food additive or as a remedy in traditional medicine for its anticancer and non-toxic effects. Thus, this research proposed the combination of curcumin and IHT as an alternative to chemotherapy in breast cancer treatment. Mice were inoculated with EMT6 breast cancer cells and assigned to 4 treatment groups: (i) untreated (control), (ii) orally curcumin (CUR), (iii) whole-body hyperthermia (FRWBH), (iv) orally curcumin with whole-body hyperthermia (FRWBH+CUR). Results showed that tumor growth inhibition and body weight gain in the combination treatment group (FRWBH+CUR) are significantly different compared to control. The group also had the longest median survival time (42 days) with no mortality observed during the experiment. This result indicates that the combination treatment is well tolerated by the mice and has negligible levels of toxicity. However, frequent complications of cancer such as anaemia and thrombocytopenia are still observed in the combination treatment group. Platelet to Lymphocyte Ratio (PLR) and Neutrophils to Lymphocytes Ratio (NLR) results indicate that the combination treatment (FRWBH+CUR) has better prognosis outcome than single treatment and may become a potential alternative antitumor treatment of breast cancer.
format	Article
author	Saim, Hanim M. Yassin, Siti Norhayati M. Salim, Maheza I. Jemon, Khairunadwa H. AlAshwal, Rania A. Wahab, Asnida Sahalan, Mariaulpa Hum, Yan Chai Lai, K. Wee
author_facet	Saim, Hanim M. Yassin, Siti Norhayati M. Salim, Maheza I. Jemon, Khairunadwa H. AlAshwal, Rania A. Wahab, Asnida Sahalan, Mariaulpa Hum, Yan Chai Lai, K. Wee
author_sort	Saim, Hanim
title	Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
title_short	Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
title_full	Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
title_fullStr	Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
title_full_unstemmed	Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
title_sort	antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer
publisher	Springer Science and Business Media B.V.
publishDate	2022
url	http://eprints.utm.my/103346/1/MahezaIrnaMohamad2022_AntitumorEffectofInfraredWhole.pdf http://eprints.utm.my/103346/ http://dx.doi.org/10.1007/s11042-022-13521-8
_version_	1781777682772525056
score	13.211869

Antitumor effect of infrared whole-body hyperthermia with curcumin in breast cancer

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