Cover Image

Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves

Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessa...

Full description

Saved in:
Bibliographic Details
Main Authors: Abdul Aziz, Ahmad Hazim, Mohd. Idrus, Nor Faadila, Nicky Rahmana Putra, Nicky Rahmana Putra, Awang, Mohd. Azrie, Idham, Zuhaili, Mamat, Hasmadi, Che Yunus, Mohd. Azizi
Format: Article
Language:English
Published: MDPI 2022
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/103035/1/MohdAziziCheYunus2022_SolubilityofRosmarinicAcidinSupercriticalCarbonDioxide.pdf
http://eprints.utm.my/103035/
http://dx.doi.org/10.3390/chemengineering6040059
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utm.103035
record_format eprints
spelling my.utm.1030352023-10-12T09:05:08Z http://eprints.utm.my/103035/ Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves Abdul Aziz, Ahmad Hazim Mohd. Idrus, Nor Faadila Nicky Rahmana Putra, Nicky Rahmana Putra Awang, Mohd. Azrie Idham, Zuhaili Mamat, Hasmadi Che Yunus, Mohd. Azizi TP Chemical technology Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessary. The present study used a green extraction method of supercritical carbon dioxide (SCCO2) extraction with the addition of ethanol as a modifier to objectively measure and correlate the solubility of RA from OS leaves. The solubility of RA in SCCO2 was determined using a dynamic extraction approach, and the solubility data were correlated using three density-based semi-empirical models developed by Chrastil, del Valle-Aguilera, and Gonzalez. Temperatures of 40, 60, and 80 °C and pressures of 10, 20, and 30 MPa were used in the experiments. The maximum RA solubility was found at 80 °C and 10 MPa with 2.004 mg of rosmarinic acid/L solvent. The RA solubility data correlated strongly with the three semi-empirical models with less than 10% AARD. Furthermore, the fastest RA extraction rate of 0.0061 mg/g min-1 was recorded at 80 °C and 10 MPa, and the correlation using the Patricelli model was in strong agreement with experimental results with less than 15% AARD. MDPI 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/103035/1/MohdAziziCheYunus2022_SolubilityofRosmarinicAcidinSupercriticalCarbonDioxide.pdf Abdul Aziz, Ahmad Hazim and Mohd. Idrus, Nor Faadila and Nicky Rahmana Putra, Nicky Rahmana Putra and Awang, Mohd. Azrie and Idham, Zuhaili and Mamat, Hasmadi and Che Yunus, Mohd. Azizi (2022) Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves. ChemEngineering, 6 (4). pp. 1-13. ISSN 2305-7084 http://dx.doi.org/10.3390/chemengineering6040059 DOI : 10.3390/chemengineering6040059
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Abdul Aziz, Ahmad Hazim
Mohd. Idrus, Nor Faadila
Nicky Rahmana Putra, Nicky Rahmana Putra
Awang, Mohd. Azrie
Idham, Zuhaili
Mamat, Hasmadi
Che Yunus, Mohd. Azizi
Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
description Rosmarinic acid (RA) is present in a broad variety of plants, including those in the Lamiaceae family, and has a wide range of pharmacological effects, particularly antioxidant activity. To extract RA from Orthosiphon stamineus (OS) leaves, a Lamiaceae plant, a suitable extraction process is necessary. The present study used a green extraction method of supercritical carbon dioxide (SCCO2) extraction with the addition of ethanol as a modifier to objectively measure and correlate the solubility of RA from OS leaves. The solubility of RA in SCCO2 was determined using a dynamic extraction approach, and the solubility data were correlated using three density-based semi-empirical models developed by Chrastil, del Valle-Aguilera, and Gonzalez. Temperatures of 40, 60, and 80 °C and pressures of 10, 20, and 30 MPa were used in the experiments. The maximum RA solubility was found at 80 °C and 10 MPa with 2.004 mg of rosmarinic acid/L solvent. The RA solubility data correlated strongly with the three semi-empirical models with less than 10% AARD. Furthermore, the fastest RA extraction rate of 0.0061 mg/g min-1 was recorded at 80 °C and 10 MPa, and the correlation using the Patricelli model was in strong agreement with experimental results with less than 15% AARD.
format Article
author Abdul Aziz, Ahmad Hazim
Mohd. Idrus, Nor Faadila
Nicky Rahmana Putra, Nicky Rahmana Putra
Awang, Mohd. Azrie
Idham, Zuhaili
Mamat, Hasmadi
Che Yunus, Mohd. Azizi
author_facet Abdul Aziz, Ahmad Hazim
Mohd. Idrus, Nor Faadila
Nicky Rahmana Putra, Nicky Rahmana Putra
Awang, Mohd. Azrie
Idham, Zuhaili
Mamat, Hasmadi
Che Yunus, Mohd. Azizi
author_sort Abdul Aziz, Ahmad Hazim
title Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
title_short Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
title_full Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
title_fullStr Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
title_full_unstemmed Solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
title_sort solubility of rosmarinic acid in supercritical carbon dioxide extraction from orthosiphon stamineus leaves
publisher MDPI
publishDate 2022
url http://eprints.utm.my/103035/1/MohdAziziCheYunus2022_SolubilityofRosmarinicAcidinSupercriticalCarbonDioxide.pdf
http://eprints.utm.my/103035/
http://dx.doi.org/10.3390/chemengineering6040059
_version_ 1781777635188146176
score 13.211869

Similar Items