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Numerical computation of ligand and signal associated to invadopodia formation

Invadopodia are protrusions that are commonly spotted at the plasma membrane of the invasive cancer cells. In forming invadopodia, several molecular interactions are involved such as the ligand, extracellular matrix (ECM), matrix metalloproteinases (MMPs), actin, and signal which are interrelated. I...

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Main Authors: Yaacob, Noorehan, Shafie, Sharidan, Suzuki, Takashi, Admon, Mohd. Ariff
Format: Article
Language:English
Published: Penerbit UTM Press 2022
Subjects:
QA Mathematics
Online Access:http://eprints.utm.my/id/eprint/102706/1/NoorehanYaacob2022_NumericalComputationofLigandandSignal.pdf
http://eprints.utm.my/id/eprint/102706/
http://dx.doi.org/10.11113/jurnalteknologi.v84.17901
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spelling my.utm.1027062023-09-18T04:09:27Z http://eprints.utm.my/id/eprint/102706/ Numerical computation of ligand and signal associated to invadopodia formation Yaacob, Noorehan Shafie, Sharidan Suzuki, Takashi Admon, Mohd. Ariff QA Mathematics Invadopodia are protrusions that are commonly spotted at the plasma membrane of the invasive cancer cells. In forming invadopodia, several molecular interactions are involved such as the ligand, extracellular matrix (ECM), matrix metalloproteinases (MMPs), actin, and signal which are interrelated. In this paper, the mathematical model of ligand and signal transduction is taken in the heat equation with the MMPs is set as function g. Besides, the actin regulation moved the interface and thus computed as the signal gradient. The mathematical model is solved using the combination of methods finite difference, ghost fluid with linear extrapolation, and level set. Apart from that, the convergence results are also given to determine the effectiveness of the above-mentioned methods. Results showed that the stimulation of signal transduction from the ligand and membrane-associated receptor binding consequently moved the plasma membrane. Also, the methods used gave a good agreement in the convergence results. Penerbit UTM Press 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/102706/1/NoorehanYaacob2022_NumericalComputationofLigandandSignal.pdf Yaacob, Noorehan and Shafie, Sharidan and Suzuki, Takashi and Admon, Mohd. Ariff (2022) Numerical computation of ligand and signal associated to invadopodia formation. Jurnal Teknologi, 84 (4). pp. 41-47. ISSN 0127-9696 http://dx.doi.org/10.11113/jurnalteknologi.v84.17901 DOI:10.11113/jurnalteknologi.v84.17901
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QA Mathematics
spellingShingle QA Mathematics
Yaacob, Noorehan
Shafie, Sharidan
Suzuki, Takashi
Admon, Mohd. Ariff
Numerical computation of ligand and signal associated to invadopodia formation
description Invadopodia are protrusions that are commonly spotted at the plasma membrane of the invasive cancer cells. In forming invadopodia, several molecular interactions are involved such as the ligand, extracellular matrix (ECM), matrix metalloproteinases (MMPs), actin, and signal which are interrelated. In this paper, the mathematical model of ligand and signal transduction is taken in the heat equation with the MMPs is set as function g. Besides, the actin regulation moved the interface and thus computed as the signal gradient. The mathematical model is solved using the combination of methods finite difference, ghost fluid with linear extrapolation, and level set. Apart from that, the convergence results are also given to determine the effectiveness of the above-mentioned methods. Results showed that the stimulation of signal transduction from the ligand and membrane-associated receptor binding consequently moved the plasma membrane. Also, the methods used gave a good agreement in the convergence results.
format Article
author Yaacob, Noorehan
Shafie, Sharidan
Suzuki, Takashi
Admon, Mohd. Ariff
author_facet Yaacob, Noorehan
Shafie, Sharidan
Suzuki, Takashi
Admon, Mohd. Ariff
author_sort Yaacob, Noorehan
title Numerical computation of ligand and signal associated to invadopodia formation
title_short Numerical computation of ligand and signal associated to invadopodia formation
title_full Numerical computation of ligand and signal associated to invadopodia formation
title_fullStr Numerical computation of ligand and signal associated to invadopodia formation
title_full_unstemmed Numerical computation of ligand and signal associated to invadopodia formation
title_sort numerical computation of ligand and signal associated to invadopodia formation
publisher Penerbit UTM Press
publishDate 2022
url http://eprints.utm.my/id/eprint/102706/1/NoorehanYaacob2022_NumericalComputationofLigandandSignal.pdf
http://eprints.utm.my/id/eprint/102706/
http://dx.doi.org/10.11113/jurnalteknologi.v84.17901
_version_ 1778160769699938304
score 13.211869

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